Results 61 to 70 of about 8,489 (158)

Hantaan virus glycoprotein Gc induces NEDD4‐dependent PTEN ubiquitination and degradation to escape the restriction of autophagosomes and facilitate viral propagation

The FASEB Journal, Volume 39, Issue 1, 15 January 2025.
The proposed model of HTNV induced PTEN degradation and PTEN‐regulated autophagy in progeny virus production: In HTNV‐infected HK‐2 cells, the viral Gc glycoprotein specifically promotes NEDD4 mediated ubiquitination and degradation of PTEN. Disruption of PTEN expression prevents autophagosome formation and increases HTNV production, whereas ...
Shuang Lu, Shuliang Chen, Yuqing Zhang, Xiaoli Mou, Mingyang Li, Shaowei Zhu, Xingyuan Chen, Tomas M. Strandin, Yale Jiang, Zhoufu Xiang, Yuanyuan Liu, Hairong Xiong, Deyin Guo, Liangjun Chen, Yirong Li, Wei Hou, Fan Luo   +16 more
wiley   +1 more source

The muskrat (Ondatra zibethicus) as a new reservoir for puumala-like hantavirus strains in Europe

, 1998
We have used an indirect immunofluorescent assay (IFA) and reverse transcription-PCR (RT-PCR) to screen the sera and tissues of muskrats (Ondatrazibethica) caught in the northwest of Brandenburg and in the northeast of Saxony-Anhalt, Germany, for ...
Tackmann, Kirsten, Schmitz, H., Müller, Thomas, Vahlenkamp, Thomas W., Löschner, U., Schreiber, M.   +5 more
core   +1 more source

First Molecular Evidence for Puumala Hantavirus in Poland [PDF]

, 2014
Puumala virus (PUUV) causes mild to moderate cases of haemorrhagic fever with renal syndrome (HFRS), and is responsible for the majority of hantavirus infections of humans in Fennoscandia, Central and Western Europe.
Groschup, Martin H., Edyta Sadowska, Gerald Heckel, Sadowska, Edyta T., Edyta T. Sadowska, Sadowska, Edyta, Koteja, Paweł, Sadowska, E.T., Sheikh Ali, Hanan, Magdalena Mikowska, Rainer Ulrich, Heckel, Gerald, Hanan Sheikh Ali, Pawel Koteja, Stephan Drewes, Hanan Ali, Koteja, Pawel, Martin Groschup, Rainer G. Ulrich, Koteja, P., Drewes, Stephan, Ulrich, Rainer G., Mikowska, Magdalena, Ali, Hanan Sheikh, Heckel, G., Mikowska, M., Martin H. Groschup   +26 more
core   +2 more sources

Reduction in mucosal‐associated invariant T cells (MAIT) in APECED patients is associated with elevated serum IFN‐γ concentration

European Journal of Immunology, Volume 54, Issue 12, December 2024.
We found a reduced frequency of circulating mucosal‐associated invariant T cells (MAITs) in patients with APECED with a clear negative correlation to inflammatory markers CRP, IL‐18, and IFN‐γ. These findings suggest that the decrease in MAITs is secondary to type 1 immune dysregulation present in the disease.
Iivo Hetemäki, Joona Sarkkinen, Huai Hui Wong, Nelli Heikkilä, Saila Laakso, Simo Miettinen, Mikko I. Mäyränpää, Outi Mäkitie, T Petteri Arstila, Eliisa Kekäläinen   +9 more
wiley   +1 more source

Rio Mamore Hantavirus Endemicity, Peruvian Amazon, 2020

Emerging Infectious Diseases
To explore hantavirus infection patterns in Latin America, we conducted molecular and serologic hantavirus investigations among 3,400 febrile patients from Peru during 2020–2021.
Marta Piche-Ovares, Maria Paquita García, Andres Moreira-Soto, Maribel Dana Figueroa-Romero, Nancy Susy Merino-Sarmiento, Adolfo Ismael Marcelo-Ñique, Edward Málaga-Trillo, Dora Esther Valencia Manosalva, Miladi Gatty-Nogueira, César Augusto Cabezas Sanchez, Jan Felix Drexler   +10 more
doaj   +1 more source

Behavioral, Physiologic, and Habitat Influences on the Dynamics of Puumala virus Infection in Bank Voles (Clethrionomys glareolus)

Emerging Infectious Diseases, 2002
Populations of bank voles (Clethrionomys glareolus) were monitored during a 4-year study in southern Belgium to assess the influence of agonistic behavior, reproductive status, mobility, and distribution of the rodents on the dynamics of Puumala virus ...
Sophie Escutenaire, Patrice Chalon, Florence de Jaegere, Lucie Karelle-Bui, Georges Mees, Bernard Brochier, Francine Rozenfeld, Paul-Pierre Pastoret   +7 more
doaj   +1 more source

Unveiling the impacts of land use on the phylogeography of zoonotic New World Hantaviruses

Ecography, Volume 2024, Issue 10, October 2024.
Billions of genomic sequences and records of species occurrence are available in public repositories (e.g. National Center for Biotechnology Information, NCBI and the Global Biodiversity Information Facility, GBIF). By implementing analytical tools from different scientific disciplines, data mining these databases can aid in the global surveillance of ...
Gabriel E. García‐Peña, André V. Rubio   +1 more
wiley   +1 more source

A severe case of Puumala hantavirus infection successfully treated with bradykinin receptor antagonist icatibant

, 2013
A patient with severe capillary leakage syndrome caused by a Puumala hantavirus infection was treated with a single dose of icatibant, a bradykinin receptor antagonist, with a dramatic positive response.
Makela, Satu, Vaheri, Antti, Mustonen, Jukka, Leppanen, Ilona, Tenhunen, Jyrki,, Antonen, Jaakko, Arvola, Pertti   +6 more
core   +1 more source

Genomic signatures of climate adaptation in bank voles

Ecology and Evolution, Volume 14, Issue 3, March 2024.
We investigated adaptive differences in 12 bank vole populations across Europe in conjunction with geographic climate variation. We used multiple genotype‐environment associations, found that mean annual temperature was a shaping factor, and identified signatures of selection in candidate genes related to lipid metabolism and the immune system.
Remco Folkertsma, Nathalie Charbonnel, Heikki Henttonen, Marta Heroldová, Otso Huitu, Petr Kotlík, Emiliano Manzo, Johanna L. A. Paijmans, Olivier Plantard, Attila D. Sándor, Michael Hofreiter, Jana A. Eccard   +11 more
wiley   +1 more source

Central nervous system manifestations in Puumala hantavirus infection [PDF]

Puumala hantavirus (PUUV) causes hemorrhagic fever with renal syndrome (HFRS). Hallmarks for the disease include fever, increased capillary permeability, thrombocytopenia, proteinuria, hematuria, oliguria, and acute kidney insufficiency.
Partanen, Terhi
core   +1 more source