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Ocular characteristics in Nephropathia epidemica or Puumala virus infection
Acta Ophthalmologica Scandinavica, 1996Abstract. Purpose: We document the largest series so far concerning the ocular characteristics of nephropathia epidemica.Methods: A total of 37 consecutive nephropathia epidemica patients underwent a comprehensive ophthalmic examination during hospitalization for systemic infection, and a control examination after recovery.Results: The most common ...
Matti Kontkanen+3 more
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Antibodies to Puumala virus in humans determined by neutralization test
Journal of Virological Methods, 1992An assay for detection of neutralizing antibodies to Puumala virus using 96-well microtiter plates (NT-ELISA) was developed and evaluated. The test proved to have similar sensitivity and specificity as an IgG ELISA and indirect immunofluorescence test, when screening 187 sera (with an antibody prevalence rate of 19%) from normal populations in an ...
John W. Huggins+3 more
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Hemorrhagic fever (Puumala virus infection) with ocular involvement
Graefe's Archive for Clinical and Experimental Ophthalmology, 1998Puumala virus infection (nephropathia epidemica) is a disease in the group of hemorrhagic fevers with renal syndrome causing ocular manifestations, e.g. transient myopia and changes in intraocular pressure.Comprehensive and repeated ophthalmic examinations of a previously healthy 35-year-old woman with acute Puumala virus infection were performed ...
Matti Kontkanen, Tuomo Puustjärvi
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[Cloning and expression of the nucleoprotein gene of Puumala-like virus].
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi, 2009In order to detect Hokkaido virus (HOKV), a recombinant baculovirus containing the nucleoprotein (NP) gene of HOKV was constructed, and then the NP was expressed in insect cell.The NP gene was cloned into plasmid PCR 2.1TA vector and then was ligated into baculovirus donor plasmid pFastBac after cutting by the restriction enzyme Kpn I and Not I ...
Ming-Hui Li+3 more
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Puumala virus reference strain for hantavirus serodiagnosis in France
European Journal of Clinical Microbiology & Infectious Diseases, 2009Dear Editor, We read with great interest the paper of C. Strady et al. on leptospirosis and nephropathia epidemica (NE) in NorthEastern-France [1]. Herein, and as questioned already before [2], the authors refer once more to the French Institut Pasteur Humain or IPH strain 90-13 for screening Puumala virus (PUUV)-induced NE cases in France with IFA and/
Jan Clement+3 more
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Immune responses to Puumala virus infection and the pathogenesis of nephropathia epidemica
Microbes and Infection, 2004Puumala virus, causative agent of a mild form of hemorrhagic fever with renal syndrome, also known as nephropathia epidemica, induces long-lasting humoral and cellular immunity in patients. The virus itself is not cytopathic, and the immune responses to the virus may be involved in teh pathogenesis of the disease.
Terajima, Masanori+4 more
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Resequencing of the Puumala virus strain Sotkamo from the WHO Arbovirus collection
Virus Genes, 2012RNA viruses exhibit a high mutation rate as the RNA-dependent RNA polymerase lacks proofreading and repair capabilities. It is known that serial passaging on cell culture leads to virus adaptation. Puumala virus (PUUV) strain Sotkamo is the prototype virus for the low-pathogenic hantavirus Puumala, family Bunyaviridae.
Alemka Markotić+2 more
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Different cross-reactivity of human and rodent sera to Tula virus and Puumala virus
Comparative Immunology, Microbiology and Infectious Diseases, 2010Tula virus (TULV) and Puumala virus (PUUV) are hantaviruses carried by the bank vole (Myodes glareolus) and European common vole (Microtus arvalis), respectively. PUUV is a causative agent of hemorrhagic fever with renal syndrome (HFRS), while TULV is thought to be apathogenic to humans.
Rika Endo+9 more
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Infection with the Puumala virus in pregnancy. Case report
BJOG: An International Journal of Obstetrics & Gynaecology, 1990S, Partanen+3 more
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Genetic analysis of Puumala viruses in Croatia
2004Puumala virus (PUUV), causative agent of the mild/moderate type of hemorrhagic fever with renal syndrome (HFRS) belongs to the Hantavirus genus in the Bunyaviridae family. HFRS is an endemic disease in Croatia. PUUV was shown to be dominant pathogen during the last HFRS outbreak in Croatia in 2002.
Puljiz, Ivan+6 more
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