Проблемы особо опасных инфекцийPuumala virus (Orthohantavirus puumalaense) is one of the causative agents of hemorrhagic fever with renal syndrome (HFRS), which is widespread in the Russian Federation (RF): more than 6 thousand cases of HFRS infection are registered annually, over the
A. E. Tishin +3 more
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Puumala Virus Infections Associated with Cardiovascular Causes of Death [PDF]
Emerging Infectious Diseases, 2013 We studied the causes of death of patients in Sweden with diagnoses of hemorrhagic fever with renal syndrome (HFRS) during 1997–2009. Cardiovascular disorders were a common cause of death during acute-phase HFRS and were the cause of death for >50% of ...
Anne-Marie Connolly-Andersen +3 more
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Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses. [PDF]
Sci Transl Med, 2022 The rodent-borne hantavirus Puumala virus (PUUV) and related agents cause hemorrhagic fever with renal syndrome (HFRS) in humans. Other hantaviruses, including Andes virus (ANDV) and Sin Nombre virus, cause a distinct zoonotic disease, hantavirus ...
Mittler E +28 more
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Puumala Virus Variants Circulating in Forests of Ardennes, France: Ten Years of Genetic Evolution. [PDF]
Pathogens, 2021 In Europe, Puumala virus (PUUV) transmitted by the bank vole (Myodes glareolus) is the causative agent of nephropathia epidemica (NE), a mild form of haemorrhagic fever with renal syndrome.
Castel G +12 more
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Monocyte subset redistribution from blood to kidneys in patients with Puumala virus caused hemorrhagic fever with renal syndrome. [PDF]
PLoS Pathog, 2021 Innate immune cells like monocytes patrol the vasculature and mucosal surfaces, recognize pathogens, rapidly redistribute to affected tissues and cause inflammation by secretion of cytokines.
Vangeti S +12 more
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Expansion of spatial and host range of Puumala virus in Sweden: an increasing threat for humans? [PDF]
Epidemiol Infect, 2017 Borg O +6 more
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Inhibition of interferon I induction by non-structural protein NSs of Puumala virus and other vole-associated orthohantaviruses: phenotypic plasticity of the protein and potential functional domains. [PDF]
Arch Virol, 2021 The orthohantavirus Puumala virus (PUUV), which is transmitted by bank voles (Clethrionomys glareolus), and other vole-borne hantaviruses contain in their small (S) genome segment two overlapping open reading frames, coding for the nucleocapsid protein ...
Binder F +6 more
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Use of a diagnostic Puumala virus real-time RT-PCR in an orthohantavirus endemic region in the Netherlands. [PDF]
Microbiol SpectrLaboratory diagnosis of orthohantavirus infection is primarily based on serology. However, for a confirmed serological diagnosis, evaluation of a follow-up serum sample is essential, which is time consuming and causes delay.
Geeraedts F +9 more
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Macropinocytosis and Clathrin-Dependent Endocytosis Play Pivotal Roles for the Infectious Entry of Puumala Virus. [PDF]
J Virol, 2020 The family Hantaviridae comprises a diverse group of virus species and is considered an emerging global public health threat. Individual hantavirus species differ considerably in terms of their pathogenicity but also in their cell biology and host ...
Bauherr S +13 more
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Of voles and men: novel Hantavirus in vitro models [PDF]
, 2013 Hantavirus-infection can cause severe disease in humans, with up to 40% case fatalities. Presently, no therapeutics or prophylaxis against hantaviral illness exists.
Sundström, Karin
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