Results 61 to 70 of about 1,020,742 (284)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Enabling Citizen Science with A Crowdfunded and Field Validated Smart Air Quality Monitor

Proceedings, 2018
This work report the preliminary results of crowdfunding/crowdsensing campaign run in Italy aimed to functional test of a smart air quality monitoring infrastructure.
Saverio De Vito, Elena Esposito, Fabrizio Formisano, Ettore Massera, Salvatore Fiore, Grazia Fattoruso, Maria Salvato, Antonio Buonanno, Paola Delli Veneri, Girolamo Di Francia   +9 more
doaj   +1 more source

A Multi-Scenario Zero-Energy Building Techno-Economic Case Study Analysis for a Renovation of a Residential Building [PDF]

Journal of Renewable Energy and Environment, 2018
According to the previous pieces of research, the building sector consumes about 40 % of total yield energy and produce one-third of GHG pollution emission.
Mohammad Ameri, Arian Gerami
doaj   +1 more source

The Exemption Status of the Bona Fide Pledgee of Unregistered Securities Under the Securities Act of 1933 [PDF]

, 1960
The number of connections of photovoltaic (PV) to distribution network is increasing. Very few PV connection guidelines that distribution system operators (DSOs) can refer to have been found.
Alvehag, Karin, Hagström, E., He, Y., Huang, Yalin, Martínez, Alberto Fernández   +4 more
core   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

A kNN based machine learning approach to automating causality assessment of adverse events

Scientific Reports
This paper introduces a machine learning classifier designed to automate causality assessment in Individual Case Safety Reports (ICSRs), utilizing the principle of event similarity.
Jun Ren, Hua Carroll, Kerry McCarthy, Jeff Allen, Jeff Tam, Jeffrey Philip, Monica Mehta, Douglas Clark   +7 more
doaj   +1 more source

The Nucleon Anapole Moment and Parity-Violating ep Scattering [PDF]

, 2000
Parity-violating (PV) interactions among quarks in the nucleon induce a PV $\gamma NN$ coupling, or anapole moment (AM). We compute electroweak gauge-independent contributions to the AM through ${\cal O}(1/\lamchis)$ in chiral perturbation theory.
B. Desplanques, B. Desplanques, B. J. Bjorken, B. R. Holstein, B. R. Holstein, C. S. Wood, D. B. Kaplan, D. B. Kaplan, D. B. Kaplan, D. London, D. T. Spayde, E. Caso, E. G. Adelberger, E. Jenkins, E. Jenkins, E. Jenkins, E. Jenkins, E. M. Henley, E. M. Henley, G. B. Feldman, G. Ecker, G. Höhler, H.-W. Hammer, I. B. Khriplovich, J. J. Sakurai, L. Durand, M. J. Musolf, M. J. Musolf, M. J. Musolf, M. J. Ramsey-Musolf, M. J. Ramsey-Musolf, N. Kaiser, N. Kaiser, R. B. Barnett, R. Balzer, S. C. Bennett, S. J. Puglia, S. Kistryn, Shi-Lin Zhu, T. R. Hemmert, Ulf-G. Meissner, Ulf-G. Meissner, Ulf.-G. Meissner, Ulf.-G. Meissner, V. Barger, V. V. Flambaum, W. C. Haxton, W. Haeberli   +47 more
core   +5 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Optimal Signal Design in System Identification for Model Predictive Control (MPC)

IEEE Access, 2023
In control engineering, system identification is frequently used to create models from input-output data. The MPC is a very well-known control strategy because of its capacity to deal with a system’s limitations.
Md. Tanjil Sarker, Gobbi Ramasamy
doaj   +1 more source

Removal of GABAA receptor γ2 subunits from parvalbumin neurons causes wide-ranging behavioral alterations [PDF]

, 2011
We investigated the behavioral significance of fast synaptic inhibition by αβγ2-type GABA(A) receptors on parvalbumin (Pv) cells. The GABA(A) receptor γ2 subunit gene was selectively inactivated in Pv-positive neurons by Cre/loxP recombination.
Leppa, E., Linden, A., Vekovischeva, O., Swinny, Jerome, Rantanen, V., Toppila, E., Hoger, H., Sieghart, W., Wulff, P., Wisden, W., Korpi, E.   +10 more
core   +1 more source