Results 101 to 110 of about 204,605 (307)

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Advanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang   +18 more
wiley   +1 more source

Wireless sensors and IoT platform for intelligent HVAC control [PDF]

, 2018
Energy consumption of buildings (residential and non-residential) represents approximately 40% of total world electricity consumption, with half of this energy consumed by HVAC systems.
Duarte, Hélder, Ferreira, Pedro M., Ruano, Antonio, Silva, Sergio   +3 more
core   +2 more sources

Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance

Advanced Science, EarlyView.
Precision engineering of plant NLR immune receptors enables rational design of enhanced pathogen resistance through mismatched pairing, domain swapping, and targeted mutagenesis. These approaches achieve multi‐fold expansion in recognition breadth while minimizing autoimmunity risks and fitness penalties.
Vinit Kumar, Vishwa I. P. W. A. Kumara, Pradeepa C. G. Bandaranayake, Dong Yawen, Yang‐Yang Gao, Junfeng Liu, Ge‐Fei Hao, Xiu‐Fang Xin   +7 more
wiley   +1 more source

Eimeria tenella protein trafficking: differential regulation of secretion versus surface tethering during the life cycle [PDF]

, 2017
Eimeria spp. are intracellular parasites that have a major impact on poultry. Effective live vaccines are available and the development of reverse genetic technologies has raised the prospect of using Eimeria spp.
Blake, D P, Crouch, C, Long, E, Marugan-Hernandez, V, Tomley, F M   +4 more
core   +1 more source

TRIM38 Suppresses Breast Cancer Progression via Modulating SQSTM1 Ubiquitination and Autophagic Flux

Advanced Science, EarlyView.
TRIM38, an E3 ubiquitin ligase, suppresses breast cancer progression by inhibiting proliferation, migration, and invasion. Downregulated in breast tumor, its loss correlates with poor prognosis. Mechanistically, TRIM38 mediates K63‐linked ubiquitination of SQSTM1/p62 at K420, disrupting SQSTM1‐LC3 interaction and blocking autophagic flux.
Shan Jiang, Lijuan Wang, Dianwen Han, Peng Su, Bing Chen, Wenjing Zhao, Tong Chen, Ning Zhang, Xiaolong Wang, Yiran Liang, Yaming Li, Chen Li, Xi Chen, Dan Luo, Qifeng Yang   +14 more
wiley   +1 more source

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk

Advanced Science, EarlyView.
Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan, Yuting Yong, Yuanshuai Li, Gaona Shi, Min Zhang, Lingfei Wan, Yue Zhao, Wenling Zhan, Yanli Lin, Qiaozhen Qin, Xupeng Chen, Yanli Ni, Haixu Chen, Wenzai Shi, Xiaomeng Guo, Juan Chen, Shuchen Liu, Youliang Wang, Bing Liu, Xinlong Yan   +19 more
wiley   +1 more source

Short-term heat acclimation is effective and may be enhanced rather than impaired by dehydration [PDF]

, 2014
Most heat acclimation data are from regimes longer than 1 week, and acclimation advice is to prevent dehydration. Objectives: We hypothesized that (i) short-term (5-day) heat acclimation would substantially improve physiological strain and exercise ...
Armstrong, Armstrong, Ashenden, Bergeron, Borg, Brandenberger, Brandenberger, Brengelmann, Buono, Buono, Burge, Casa, Casa, Cheung, Convertino, Convertino, Costill, Cotter, Creasy, Dill, Engell, Epstein, Fellman, Fleming, Fortney, Francesconi, Gabai, Gagge, Garrett, Garrett, Garrett, Gisolfi, Gonzalez-Alonso, Gore, Goulet, Graichen, Greenleaf, Harrison, Harrison, Hopkins, Hopper, Horowitz, Horowitz, Hurwitz, Joyner, Judelson, Kay, Kee-Bum, Kenefick, Lorenzo, Maresh, Marshall, McClung, McConell, Merry, Morris, Moseley, Nadel, Nagashima, Nielsen, Njemini, Noakes, Nose, Oehler, Okazaki, Okazaki, Patterson, Patterson, Patterson, Racinais, Ramanathan, Sawka, Sawka, Sawka, Sawka, Schwimmer, Scoon, Senay, Shido, Shvartz, Strydom, Tetievsky, Turk, Wall, Weller, Witney, Wyndham   +86 more
core   +1 more source

MDP25‐VDAC3 Complex Orchestrates Actin Remodeling and Mitochondrial Dynamics to Modulate Innate Immunity in Arabidopsis

Advanced Science, EarlyView.
This study reveals that actin remodeling regulates mitochondrial elongation as a defense strategy in plants. Flagellin perception induces fusion‐dependent elongation, supported by cortical actin bundles, to repair damage and boost ATP and ROS production.
Junxiu Hou, Pengfei Lu, Xuan Cui, Liangfeng Luo, Qing Pan, Jiejie Li   +5 more
wiley   +1 more source

Simulating shadow effect on PV panels

RE&PQJ
Through this paper we study losses that occur in a photovoltaic system by making simulations using the following software: Pspice and PVSYST, emphasizing the moment when the PV cells are shaded or covered, namely when the level of irradiation is not uniform throughout the module. In technical literature, the irradiation degree of solar panels is one of
null L. Dorobantu, null M.O. Popescu, null Cl. Popescu, null A. Craciunescu   +3 more
openaire   +1 more source

Value relevance of troubled debt restructurings and policy implications [PDF]

, 2005
This paper investigates the beneficial economic consequences and market and accounting based valuation effects of troubled debt restructurings (TDR) in financially distressed debtor firms.
Aksu, Mine Hatice
core   +1 more source