Results 51 to 60 of about 1,540 (169)

Visual loss and presumed pseudoxanthoma elasticum confirmed with genetic analysis but not with skin examination and biopsies

GMS Ophthalmology Cases, 2011
Objective: Case report of a patient with angioid streaks, peau d’orange, comet tail lesions, choroidal neovascularisation and presumed pseudoxanthoma elasticum (PXE). PXE was confirmed by gene analysis but not by skin biopsies.
Aerts, Carolien, De Keyser, Christophe, Leys, Anita   +2 more
doaj  

Phosphate in Physiological and Pathological Mineralization: Important yet Often Unheeded

MedComm, Volume 6, Issue 7, July 2025.
Phosphate serves as a building block for physiological mineralization, and as a signaling molecule that regulates the activity of mineralizing cells. The disturbance in these processes could induce a series of pathological mineralization, with abnormal mineralization of hard tissues and ectopic mineralization of soft tissues being the most ...
Wen Qin, San‐yang Yu, Jia‐lu Gao, Jian‐fei Yan, Qian‐qian Wan, Shuai‐lin Jia, Franklin Tay, Kai Jiao, Lina Niu   +8 more
wiley   +1 more source

A case of angioid streaks that produced choroidal neovascularization after the onset of unilateral acute retinopathy in pseudoxanthoma elasticum

American Journal of Ophthalmology Case Reports, 2022
Purpose: To report a case of angioid streaks that showed non-exudative choroidal neovascularization (CNV) after the onset of acute retinopathy in pseudoxanthoma elasticum (PXE).
Akika Kyo, Manabu Yamamoto, Shigeru Honda   +2 more
doaj   +1 more source

The Interconnected World of Dermatology and Ophthalmology

JEADV Clinical Practice, Volume 4, Issue 2, Page 389-399, June 2025.
Medical science, is an integrated field that shares intricate relationship between various organ systems. Similarly, dermatology is inter‐related with various other specialties including ophthalmology. This article depicts the correlation of ophthalmology and dermatology iterating on the genetic diseases, autoimmune diseases, systemic disorders ...
Gyanesh Rathore, Surajit Gorai, Gitikash Purkayastha, Kinnor Das, Prajwal Pudasaini   +4 more
wiley   +1 more source

Pseudoxanthoma elasticum and reflectance confocal microscopy: report of two affected young sisters

Journal of Pediatric and Neonatal Individualized Medicine, 2015
Pseudoxanthoma elasticum (PXE) is a rare inherited multisystem disorder that mainly affects skin, eyes and cardiovascular system. The associated clinical signs are due to progressive calcification of elastic fibres and blood vessels, despite normal ...
Victor Desmond Mandel, Federica Boraldi, Giovanni Pellacani, Silvana Ciardo, Giovanna Mazzaglia, Francesca Farnetani   +5 more
doaj   +1 more source

Oral Citrate Supplementation Mitigates Age‐Associated Pathologic Intervertebral Disc Calcification in LG/J Mice

Aging Cell, Volume 24, Issue 5, May 2025.
An endochondral differentiation process in the CEPs drives pathologic disc calcification in aging LG/J mice, and NP cell hypertrophic transdifferentiation secondarily contributes. Supplementing drinking water with 80 mM K3Citrate during aging markedly reduced disc calcification, attenuated NP cell transdifferentiation, and mildly improved NP and AF ...
Olivia K. Ottone, Jorge J. Mundo, Boahen N. Kwakye, Amber Slaweski, John A. Collins, Qinglin Wu, Margery A. Connelly, Fatemeh Niaziorimi, Koen van de Wetering, Makarand V. Risbud   +9 more
wiley   +1 more source

Pharmacokinetics and Safety of Oral Pyrophosphate in Systemic Sclerosis Patients—A Pilot Study

ACR Open Rheumatology, Volume 7, Issue 4, April 2025.
Objective Calcinosis is a manifestation of systemic sclerosis with a severe negative impact on quality of life. Efforts to find a treatment for calcinosis have been hindered by our limited understanding of the underlying pathomechanism. We propose that extracellular pyrophosphate deficiency may have a causal role in the formation of these mineralized ...
Gergely Bodor, Márta Bocskai, Ágnes Dura, László Kovács, András Váradi, Eszter Kozák   +5 more
wiley   +1 more source

Higher Food and Lifestyle Oxidative Balance Scores Decreases the Risk of Hypertension in Chinese Adults: A Population‐Based Cross‐Sectional Study

The Journal of Clinical Hypertension, Volume 27, Issue 4, April 2025.
ABSTRACT Oxidative stress plays an important role in the development of hypertension (HTN). A population‐based cross‐sectional study was conducted in Fujian province of China. The construction of FoodL‐OBS relied on diet and lifestyle components, which included four food and six lifestyle factors.
Wenxin Qiu, Ying Han, Jingru Huang, Danjing Chen, Jiangwang Fang, Huajing Chang, Xian‐e Peng   +6 more
wiley   +1 more source

Pseudoxanthoma elasticum with periumbilical perforation in a Nullipara

Indian Journal of Dermatology, 2012
Pseudoxanthoma elasticum (PXE) is an inherited multisystem disorder that primarily affects the skin and is characterized by progressive calcification and degeneration of the elastic fibers. PXE has recently been found to be caused by mutations in the ATP-
Parimalam Kumar, Athilakshmi Sivasubramanian, Sampath Vadivel, Manoharan Krishnaswamy   +3 more
doaj   +1 more source

Biological Activity of Biomarkers Associated With Metastasis in Osteosarcoma Cell Lines

Cancer Medicine, Volume 14, Issue 6, March 2025.
Osteosarcoma presents diagnostic and treatment challenges due to its unclear etiology and frequent late‐stage detection. This study aims to identify metastasis biomarkers in osteosarcoma cell lines and biopsies. Through RNA evaluation, a gene functional enrichment analysis of DEGs enabled the identification of interaction networks in osteosarcoma ...
Nidia Ednita Beltrán‐Hernández, Luis Cardenas, Verónica Jimenez‐Jacinto, Leticia Vega‐Alvarado, Heriberto Manuel Rivera   +4 more
wiley   +1 more source