Results 71 to 80 of about 2,584 (187)

Oral Citrate Supplementation Mitigates Age‐Associated Pathologic Intervertebral Disc Calcification in LG/J Mice

Aging Cell, Volume 24, Issue 5, May 2025.
An endochondral differentiation process in the CEPs drives pathologic disc calcification in aging LG/J mice, and NP cell hypertrophic transdifferentiation secondarily contributes. Supplementing drinking water with 80 mM K3Citrate during aging markedly reduced disc calcification, attenuated NP cell transdifferentiation, and mildly improved NP and AF ...
Olivia K. Ottone, Jorge J. Mundo, Boahen N. Kwakye, Amber Slaweski, John A. Collins, Qinglin Wu, Margery A. Connelly, Fatemeh Niaziorimi, Koen van de Wetering, Makarand V. Risbud   +9 more
wiley   +1 more source

Pharmacokinetics and Safety of Oral Pyrophosphate in Systemic Sclerosis Patients—A Pilot Study

ACR Open Rheumatology, Volume 7, Issue 4, April 2025.
Objective Calcinosis is a manifestation of systemic sclerosis with a severe negative impact on quality of life. Efforts to find a treatment for calcinosis have been hindered by our limited understanding of the underlying pathomechanism. We propose that extracellular pyrophosphate deficiency may have a causal role in the formation of these mineralized ...
Gergely Bodor, Márta Bocskai, Ágnes Dura, László Kovács, András Váradi, Eszter Kozák   +5 more
wiley   +1 more source

Higher Food and Lifestyle Oxidative Balance Scores Decreases the Risk of Hypertension in Chinese Adults: A Population‐Based Cross‐Sectional Study

The Journal of Clinical Hypertension, Volume 27, Issue 4, April 2025.
ABSTRACT Oxidative stress plays an important role in the development of hypertension (HTN). A population‐based cross‐sectional study was conducted in Fujian province of China. The construction of FoodL‐OBS relied on diet and lifestyle components, which included four food and six lifestyle factors.
Wenxin Qiu, Ying Han, Jingru Huang, Danjing Chen, Jiangwang Fang, Huajing Chang, Xian‐e Peng   +6 more
wiley   +1 more source

Biological Activity of Biomarkers Associated With Metastasis in Osteosarcoma Cell Lines

Cancer Medicine, Volume 14, Issue 6, March 2025.
Osteosarcoma presents diagnostic and treatment challenges due to its unclear etiology and frequent late‐stage detection. This study aims to identify metastasis biomarkers in osteosarcoma cell lines and biopsies. Through RNA evaluation, a gene functional enrichment analysis of DEGs enabled the identification of interaction networks in osteosarcoma ...
Nidia Ednita Beltrán‐Hernández, Luis Cardenas, Verónica Jimenez‐Jacinto, Leticia Vega‐Alvarado, Heriberto Manuel Rivera   +4 more
wiley   +1 more source

Glycerophospholipids: Roles in Cell Trafficking and Associated Inborn Errors

Journal of Inherited Metabolic Disease, Volume 48, Issue 2, March 2025.
ABSTRACT Glycerophospholipids (GPLs) are the main lipid components of cellular membranes. They are implicated in membrane structure, vesicle trafficking, neurotransmission, and cell signalling. GPL molecules are amphiphilic, organized around the three carbons of glycerol. Positions sn‐1 and sn‐2 are each esterified to a fatty acid (FA).
Foudil Lamari, Francis Rossignol, Grant A. Mitchell   +2 more
wiley   +1 more source

Pseudoxanthoma Elasticum (PXE)

, 1970
Pseudoxanthoma elasticum (PXE) Right eye shows angiod streaks with associated hemorrhage. Patient was 25 year old man who developed a right sided carotid cavernous fistula. Anatomy: Retina. Pathology: Pseudoxanthoma elasticum (PXE).
William F. Hoyt, MD
core  

Matrix gla protein and alkaline phosphatase are differently modulated in human dermal fibroblasts from PXE patients and controls [PDF]

, 2013
Mineralization of elastic fibers in pseudoxanthoma elasticum (PXE) has been associated with low levels of carboxylated matrix gla protein (MGP), most likely as a consequence of reduced vitamin K (vit K) availability.
Vermeer, Cees, TIOZZO, Roberta, QUAGLINO, Daniela, ANNOVI, Giulia, Trenti, Tommaso, Schurgers, Leon J.; id_orcid, BORALDI, Federica, Trenti, Tornmaso, Trenti, T., GUERRA, Deanna, Vermeer, C., Schurgers, L. J., Schurgers, Leon J.   +12 more
core   +1 more source

Disease Advocacy Organizations Catalyze Translational Research

Frontiers in Genetics, 2013
Disease advocacy organizations have long played an important role in the continuum from basic science to therapy development in rare disease research. PXE International has sometimes led the field in innovative ways, venturing into specific activities ...
Sharon Fontaine Terry, Sharon Fontaine Terry   +1 more
doaj   +1 more source

Liquid Polycaprolactone (PCL) for Reversing PXE's Skin Laxity of Inner Thighs and Knees: A Case Report

Journal of Cosmetic Dermatology, Volume 24, Issue 2, February 2025.
ABSTRACT Background/Aim Pseudoxanthoma elasticum (PXE) is a genetic connective tissue disorder that affects the skin with limited treatment options. A recent technology employing particle‐free polycaprolactone (PCL) has shown promising results in treating inner thighs and kness of a 27‐year‐old female patient.
Emmanouil Dimonitsas, Agni Albanopoulou, Foteini Neamonitou, Eleftheria Lakiotaki, Penelope Korkolopoulou, Maria Gazouli   +5 more
wiley   +1 more source

Lansoprazole increases inorganic pyrophosphate in patients with pseudoxanthoma elasticum: a double-blind, randomized, placebo-controlled crossover trial

, 2023
Pseudoxanthoma elasticum (PXE) is characterized by low levels of inorganic pyrophosphate (PPi) and a high activity of tissue-nonspecific alkaline phosphatase (TNAP). Lansoprazole is a partial inhibitor of TNAP.
González Jiménez, Andrés, Baquero Aranda, Isabel, Merino Bohórquez, Vicente, Murcia Casas, Belén, Carrillo Linares, Juan Luis, Rico Corral, Miguel Ángel, Rioja Villodres, José, Valdivielso, Pedro   +7 more
core   +1 more source