Results 41 to 50 of about 499,076 (237)

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Cortical EFPs and DRPs are suppressed after pyramidal tract lesions.

, 2013
Averaged EFPs (top traces) and DRPs (bottom traces), evoked by contralateral sensorimotor cortex stimulation, recorded in the L4 spinal cord segment before and after electrolytic lesion of the ipsilateral pyramidal tract at the medullary level.
Gerardo Rojas-Piloni (439444), Jimena Pérez-Sánchez (439441), Yunuen Moreno-López (439440), Guadalupe Martínez-Lorenzana (439442), Miguel Condés-Lara (439443)   +4 more
core   +1 more source

Single collateral reconstructions reveal distinct phases of corticospinal remodeling after spinal cord injury. [PDF]

, 2012
Injuries to the spinal cord often result in severe functional deficits that, in case of incomplete injuries, can be partially compensated by axonal remodeling.
Bareyre Florence M., Martin Kerschensteiner, Lang Claudia, Guo, Xiaoli, Xiaoli Guo, Guo Xiaoli, Florence M Bareyre, Lang, Claudia, Bareyre, Florence M., Claudia Lang, Kerschensteiner Martin, Kerschensteiner, Martin   +11 more
core   +2 more sources

Sinais de Babinski e Chaddock sem disfunção piramidal aparente Babinski and Chaddock signs without apparent pyramidal disfunction

Arquivos de Neuro-Psiquiatria, 2005
OBJETIVO: Verificar a presença dos sinais de Babinski e de Chaddock em cem pacientes sem história ou indícios clínicos de comprometimento da via piramidal, internados no Serviço de Clínica Médica do Hospital Universitário Clementino Fraga Filho da ...
Péricles Maranhão-Filho, Eduardo Dib, Rodrigo Gaspar Ribeiro   +2 more
doaj   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

New Corticopontine Connections in the Primate Brain: Contralateral Projections From the Arm/Hand Area of the Precentral Motor Region

Frontiers in Neuroanatomy, 2018
The ipsilateral corticopontine projection (iCPP) represents a massive descending axon system terminating in the pontine nuclei (PN). In the primate, this projection is well known for its dominant influence on contralateral upper limb movements through ...
Robert J. Morecraft, Jizhi Ge, Kimberly S. Stilwell-Morecraft, Diane L. Rotella, Marc A. Pizzimenti, Marc A. Pizzimenti, Warren G. Darling   +6 more
doaj   +1 more source

Parallel processing of working memory and temporal information by distinct types of cortical projection neurons

Nature Communications, 2021
Intratelencephalic and pyramidal tract neurons are two major types of cortical excitatory neurons that project to cortical and subcortical structures.
Jung Won Bae, Huijeong Jeong, Young Ju Yoon, Chan Mee Bae, Hyeonsu Lee, Se-Bum Paik, Min Whan Jung   +6 more
doaj   +1 more source

Distinct populations of cortical pyramidal neurons mediate drug reward and aversion

Nature Communications, 2021
The anterior cingulate plays a role in addiction, but studies have not examined the role of its two types of glutamatergic projection neurons, pyramidal tract (PT) and intratelencephalic (IT).
A. F. Garcia, E. A. Crummy, I. G. Webb, M. N. Nooney, S. M. Ferguson   +4 more
doaj   +1 more source

Subclinical Optic Nerve Involvement in Radiologically Isolated Syndrome: Multimodal Detection and Diagnostic Impact

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay, Cassandre Landes‐Château, Lydiane Mondot, Mikael Cohen, Margherita Popolo, Jérôme de Seze, Bertrand Bourre, Françoise Durand‐Dubief, Olivier Casez, Orhun H. Kantarci, Aksel Siva, Stephanie Baillif, Darin T. Okuda, Letizia Leocani   +13 more
wiley   +1 more source

Autoimmune cerebellopyramidal syndrome as a complex form of autoimmune cerebellar ataxia: a cohort study

Frontiers in Immunology
BackgroundAutoimmune cerebellar ataxia (ACA) is a significant and treatable cause of sporadic cerebellar syndrome. Pyramidal tract damage affects approximately 30% of ACA patients, profoundly impacts motor function and prognosis, yet this complex form ...
Mange Liu, Haitao Ren, Siyuan Fan, Le Zhang, Hongzhi Guan   +4 more
doaj   +1 more source