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Modeling Pyran Formation in the Molybdenum Cofactor: Protonation of Quinoxalyl–Dithiolene Promoting Pyran Cyclization [PDF]

open access: yesInorganic Chemistry, 2019
Mononuclear Mo and W enzymes require a unique ligand known as molybdopterin (MPT). This ligand binds the metal through a dithiolene chelate, and the dithiolene bridges a reduced pyranopterin group. Pyran scission and formation have been proposed as a reaction of the MPT ligand that may occur within the enzymes to adjust reactivity at the Mo atom.
Douglas R. Gisewhite   +4 more
openaire   +2 more sources

Synthesis of Polyfunctionalized 4H‐Pyrans [PDF]

open access: yesJournal of Chemistry, 2012
Amberlyst A21 catalyzed one‐pot three‐component coupling of aldehyde and malononitrile with active methylene compounds such as acetylacetone and ethyl acetoacetate for the synthesis of pharmaceutically important polyfunctionalized 4H‐pyrans has been reported. Simple experimental procedure, no chromatographic purification, no hazardous organic solvents,
Manisha Bihani   +2 more
openaire   +2 more sources

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