Results 11 to 20 of about 1,359 (168)

Activity of oxantel pamoate monotherapy and combination chemotherapy against Trichuris muris and hookworms : revival of an old drug [PDF]

, 2013
BACKGROUND: It is widely recognized that only a handful of drugs are available against soil-transmitted helminthiasis, all of which are characterized by a low efficacy against Trichuris trichiura, when administered as single doses.
Speich Benjamin, Tritten Lucienne, Jennifer Keiser, Speich, B., Keiser Jennifer, Benjamin Speich, Adelfio Roberto, Keiser, J., Adelfio, R., Tritten, L., Silbereisen Angelika, Vargas Mireille, Angelika Silbereisen, Roberto Adelfio, Silbereisen, A., Vargas, M., Lucienne Tritten, Mireille Vargas, Speich B, Keiser J, Tritten L, Adelfio R, Silbereisen A, Vargas M   +23 more
core   +2 more sources

Case Report: The Successful Treatment of Toxocariasis in a Domestic Cat using Pyrantel Pamoate [PDF]

, 2023
Toxocariasis is an infectious disease caused by Toxocara sp. in cats that lead to deterioration of the condition and can even cause death, especially in kittens. Pyrantel pamoate is an anthelmintic that is currently being abandoned for toxocariasis.
Dami, Juni Claudia, Priyowidodo, Dwi, Indarjulianto, Soedarmanto, Wijayanti, Agustina Dwi, Yanuartono, Yanuartono, Damayanti, Luh Putu Eka   +5 more
core   +1 more source

Laboratory and field studies to investigate the efficacy of a novel, orally administered combination product containing moxidectin, sarolaner and pyrantel for the prevention of heartworm disease (Dirofilaria immitis) in dogs

Parasites & Vectors, 2019
Background Dirofilaria immitis is a filarial parasite of dogs that can cause serious or fatal cardiopulmonary disease. Three studies were conducted to evaluate the efficacy and safety of monthly treatment with moxidectin in a chewable tablet product in ...
Kristina Kryda, Robert H. Six, Kelly F. Walsh, Susan J. Holzmer, Sara Chapin, Sean P. Mahabir, Melanie Myers, Tammy Inskeep, Jady Rugg, Blair Cundiff, Aleah Pullins, Michael Ulrich, John W. McCall, Tom L. McTier, Steven J. Maeder   +14 more
doaj   +1 more source

Phenotypic Characterization of Two Ancylostoma caninum Isolates with Different Susceptibilities to the Anthelmintic Pyrantel [PDF]

, 2008
The anthelmintic pyrantel plays an important role in the control of gastrointestinal helminths of humans and domestic animals. Despite the demonstration of pyrantel resistance in several helminth species over the last 20 years, the resistance mechanism ...
S. R. Kopp, J. S. McCarthy, A. C. Kotze, G. T. Coleman, Kopp, Steven R., Kotze, Andrew C., Coleman, Glen T., McCarthy, James S.   +7 more
core   +1 more source

Efficacy of orally administered combination of moxidectin, sarolaner and pyrantel (Simparica Trio™) for the prevention of experimental Angiostrongylus vasorum infection in dogs

Parasites & Vectors, 2020
Background Infection with Angiostrongylus vasorum may cause severe clinical disease, even death in dogs, however, due to the often non-specific clinical signs, diagnosis is not always straightforward. Regular prophylactic treatment may offer a safe means
Csilla Becskei, Mirjan Thys, Padraig Doherty, Sean P. Mahabir   +3 more
doaj   +1 more source

Molecular Determinants of Pyrantel Selectivity in Nicotinic Receptors [PDF]

, 2006
Nicotinic receptors (AChRs) play key roles in synaptic transmission throughout the nervous system. AChRs mediate neuromuscular transmission in nematodes and they are targets for antiparasitic drugs.
Bartos, Mariana, Rayes, Diego Hernán, Bouzat, Cecilia Beatriz   +2 more
core   +1 more source

Effect of pyrantel and dimethoate administration on rat liver cytochrome P450 system

, 2006
The cytochrome P450 system in rat liver after administration of dimethoate (5 d, 1/10 DL50), pyrantel embonate (3 d, 1/5 DL50) or both xenobiotics simultaneously was analysed.
Barski, Dariusz, Czajkowska, Beata, Pałasz, Artur, Zasadowski, Arkadiusz, Czekaj, Piotr, Wiaderkiewicz, Ryszard, Wiaderkiewicz, Anna   +6 more
core   +4 more sources

Pharmacokinetics of praziquantel and pyrantel pamoate combination following oral administration in cats [PDF]

, 2017
Objectives The pharmacokinetics of praziquantel and pyrantel pamoate has never been reported in cats. The present study was designed to establish the plasma concentration–time profile and to derive pharmacokinetic data for a combined formulation of ...
László Gagyi, Emilio Fernández-Varón, Carlos M Cárceles, Laurent Ognean, Alexandra Arion   +4 more
core   +2 more sources

UPLC-MS/MS method for simultaneous determination of pyrantel, praziquantel, febantel, fenbendazole and oxfendazole in dog plasma and its application to a bioequivalence study

Frontiers in Pharmacology
A rapid, sensitive and reliable ultra–performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) was developed and validated for the simultaneous quantitation of pyrantel (PYR), praziquantel (PRA), febantel (FBT) and its active metabolites ...
Fengyichi Zhang, Fanxi Guo, Xinyu Zhao, Chongyang Li, Junli Wang, Mengyun Wang, Ruixia Ma, Baochang Chen, Qiangqiang Miao, Yimeng Wang, Zihan Wang, Di Cao, Zugong Yu   +12 more
doaj   +1 more source

The new anthelmintic tribendimidine is an L-type (levamisole and pyrantel) nicotinic acetylcholine receptor agonist. [PDF]

PLoS Neglected Tropical Diseases, 2009
Intestinal parasitic nematodes such as hookworms, Ascaris lumbricoides, and Trichuris trichiura are amongst most prevalent tropical parasites in the world today.
Yan Hu, Shu-Hua Xiao, Raffi V Aroian
doaj   +1 more source