Results 11 to 20 of about 2,996 (200)

Apparent treatment failure of praziquantel and pyrantel pamoate against anoplocephalid tapeworms

International Journal for Parasitology: Drugs and Drug Resistance, 2023
Anoplocephalid tapeworms are commonly occurring in grazing horses around the world. Two currently available anthelmintics have documented high efficacy against Anoplocephala perfoliata; praziquantel in various dosages ranging from 1.0 to 2.5 mg/kg and ...
M.K. Nielsen
core   +2 more sources

Endoscopic Diagnosis of <i>Necator americanus</i> Infection Presenting With Persistent Iron-Deficiency Anemia: Usefulness of Image-Enhanced Endoscopy and Capsule Endoscopy. [PDF]

DEN Open
ABSTRACT Necator americanus infection is now rare in developed countries but remains an important cause of iron‐deficiency anemia and abdominal symptoms in individuals with relevant epidemiological backgrounds. A 59‐year‐old Filipino man with long‐standing unexplained iron‐deficiency anemia was admitted to our hospital for epigastric pain associated ...
Takebe T, Osawa S, Watanabe Y, Yamagata S, Aoyama T, Kawamura Y, Manabe A, Kisamori T, Sano M, Sugimoto K.   +9 more
europepmc   +2 more sources

In vivo efficacy of pyrantel pamoate as a post-exposure prophylactic for rat lungworm (Angiostrongylus cantonensis)

International Journal for Parasitology: Drugs and Drug Resistance, 2022
Rat lungworm (Angiostrongylus cantonensis) is a neurotropic nematode, and the leading cause of eosinophilic meningitis worldwide. The parasite is usually contracted through ingestion of infected gastropods, often hidden in raw or partially cooked produce.
John Jacob, Argon Steel, Lisa Kaluna, Steven Hess, Israel Leinbach, Carmen Antaky, Robert Sugihara, Lindsey Hamilton, Peter Follett, Kathleen Howe, Steven Jacquier, Supakit Wongwiwatthananukit, Susan Jarvi   +12 more
doaj   +1 more source

Field efficacy and safety evaluation of a novel chewable tablet (Credelio Quattro™) containing lotilaner, moxidectin, praziquantel, and pyrantel against gastrointestinal nematode infections in dogs in the USA. [PDF]

Parasit Vectors
Background Gastrointestinal nematodes such as hookworms (Ancylostoma caninum) and roundworms (Toxocara canis) commonly infect dogs and are zoonotic parasites capable of producing clinical disease in humans.
Charles S, Wiseman S, Savadelis MD, Nichols E, Young L.   +4 more
europepmc   +2 more sources

Probing Cinnamamides and Benzamides as Anthelmintics: Discovery of Potent Drug-Like Agents Against Angiostrongylus cantonensis. [PDF]

Chem Biol Drug Des
Cynnamoyl benzylpiperazine was identified as drug‐like derivative of cinnarizine with anthelmintic activity against A. cantonensis. In this work, 15 out of 31 derivatives showed improved anthelmintic activity with increased solubility. A SAR study was carried out to determine the molecular features involved in such effect.
Lemes BL, Siegl-Breno MA, Varela MT, Lopes FB, Silva-Nunes MK, Santos TD, Fukui-Silva L, Roquini DB, Maltarollo VG, de Moraes J, Fernandes JPS.   +10 more
europepmc   +2 more sources

Corticosterone Under Experimental Manipulation of Nutrition and Parasite Burden in a Wild Rodent System. [PDF]

J Exp Zool A Ecol Integr Physiol
ABSTRACT Environmental pressures shape survival and life‐history dynamics partly by triggering the release of glucocorticoids, whose short‐term benefits but long‐term costs make it essential to understand what drives their levels. Here, we used an experimental manipulation of two environmental stressors—food availability and parasite burden—to directly
Wolf SE, Dłużniewska O, Babayan SA, Pedersen AB, Little TJ.   +4 more
europepmc   +2 more sources

Total Failure of Fenbendazole to Control Strongylid Infections in Czech Horse Operations

Frontiers in Veterinary Science, 2022
The control of strongylid infections has become challenging globally for equine practitioners due to the development of anthelmintic resistance. Comprehensive information on anthelmintic resistance in the Czech Republic, however, is still lacking.
Jana Nápravníková, Marián Várady, Jaroslav Vadlejch   +2 more
doaj   +1 more source

Pharmacokinetics of praziquantel and pyrantel pamoate combination following oral administration in cats [PDF]

, 2017
Objectives The pharmacokinetics of praziquantel and pyrantel pamoate has never been reported in cats. The present study was designed to establish the plasma concentration–time profile and to derive pharmacokinetic data for a combined formulation of ...
László Gagyi, Emilio Fernández-Varón, Carlos M Cárceles, Laurent Ognean, Alexandra Arion   +4 more
core   +2 more sources

The nicotinic acetylcholine receptors of the parasitic nematode Ascaris suum: formation of two distinct drug targets by varying the relative expression levels of two subunits. [PDF]

PLoS Pathogens, 2009
Parasitic nematodes are of medical and veterinary importance, adversely affecting human health and animal welfare. Ascaris suum is a gastrointestinal parasite of pigs; in addition to its veterinary significance it is a good model of the human parasite ...
Sally M Williamson, Alan P Robertson, Laurence Brown, Tracey Williams, Debra J Woods, Richard J Martin, David B Sattelle, Adrian J Wolstenholme   +7 more
doaj   +1 more source

Activity of oxantel pamoate monotherapy and combination chemotherapy against Trichuris muris and hookworms : revival of an old drug [PDF]

, 2013
BACKGROUND: It is widely recognized that only a handful of drugs are available against soil-transmitted helminthiasis, all of which are characterized by a low efficacy against Trichuris trichiura, when administered as single doses.
Speich Benjamin, Tritten Lucienne, Jennifer Keiser, Speich, B., Keiser Jennifer, Benjamin Speich, Adelfio Roberto, Keiser, J., Adelfio, R., Tritten, L., Silbereisen Angelika, Vargas Mireille, Angelika Silbereisen, Roberto Adelfio, Silbereisen, A., Vargas, M., Lucienne Tritten, Mireille Vargas   +17 more
core   +2 more sources