Results 31 to 40 of about 2,996 (200)

Efficacy of orally administered combination of moxidectin, sarolaner and pyrantel (Simparica Trio™) for the prevention of experimental Angiostrongylus vasorum infection in dogs

Parasites & Vectors, 2020
Background Infection with Angiostrongylus vasorum may cause severe clinical disease, even death in dogs, however, due to the often non-specific clinical signs, diagnosis is not always straightforward. Regular prophylactic treatment may offer a safe means
Csilla Becskei, Mirjan Thys, Padraig Doherty, Sean P. Mahabir   +3 more
doaj   +1 more source

Molecular Determinants of Pyrantel Selectivity in Nicotinic Receptors [PDF]

, 2006
Nicotinic receptors (AChRs) play key roles in synaptic transmission throughout the nervous system. AChRs mediate neuromuscular transmission in nematodes and they are targets for antiparasitic drugs.
Bartos, Mariana, Rayes, Diego Hernán, Bouzat, Cecilia Beatriz   +2 more
core   +1 more source

The new anthelmintic tribendimidine is an L-type (levamisole and pyrantel) nicotinic acetylcholine receptor agonist. [PDF]

PLoS Neglected Tropical Diseases, 2009
Intestinal parasitic nematodes such as hookworms, Ascaris lumbricoides, and Trichuris trichiura are amongst most prevalent tropical parasites in the world today.
Yan Hu, Shu-Hua Xiao, Raffi V Aroian
doaj   +1 more source

Pyrantel-resistant cyathostomins are hypersusceptible to Cry5B.

, 2018
Dose-dependent developmental inhibition of a non-anthelmintic resistant population of cyathostomins (Barn 10; [62]) and of an anthelmintic-resistant population of cyathostomins (pyrantel-resistant Population S or PYR_R) to (A) pyrantel and (B) purified ...
Raffi V. Aroian (103098), Thanh-Thanh Nguyen (5236655), Melanie Miller (1579858), Yan Hu (30839), Bo Zhang (6559), Martin K. Nielsen (5236652)   +5 more
core   +1 more source

UPLC-MS/MS method for simultaneous determination of pyrantel, praziquantel, febantel, fenbendazole and oxfendazole in dog plasma and its application to a bioequivalence study

Frontiers in Pharmacology
A rapid, sensitive and reliable ultra–performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) was developed and validated for the simultaneous quantitation of pyrantel (PYR), praziquantel (PRA), febantel (FBT) and its active metabolites ...
Fengyichi Zhang, Fanxi Guo, Xinyu Zhao, Chongyang Li, Junli Wang, Mengyun Wang, Ruixia Ma, Baochang Chen, Qiangqiang Miao, Yimeng Wang, Zihan Wang, Di Cao, Zugong Yu   +12 more
doaj   +1 more source

Efficacy evaluation of anthelmintic products against an infection with the canine hookworm (Ancylostoma caninum) isolate Worthy 4.1F3P in dogs

International Journal for Parasitology: Drugs and Drug Resistance, 2020
Ancylostoma caninum is the most prevalent intestinal nematode of dogs, and has a zoonotic potential. Multiple-drug resistance (MDR) has been confirmed in a number of A.
Pablo D. Jimenez Castro, Abdelmoneim Mansour, Samuel Charles, Joe Hostetler, Terry Settje, Daniel Kulke, Ray M. Kaplan   +6 more
doaj   +1 more source

Case Report: The Successful Treatment of Toxocariasis in a Domestic Cat using Pyrantel Pamoate [PDF]

, 2023
Toxocariasis is an infectious disease caused by Toxocara sp. in cats that lead to deterioration of the condition and can even cause death, especially in kittens. Pyrantel pamoate is an anthelmintic that is currently being abandoned for toxocariasis.
Dami, Juni Claudia, Priyowidodo, Dwi, Indarjulianto, Soedarmanto, Wijayanti, Agustina Dwi, Yanuartono, Yanuartono, Damayanti, Luh Putu Eka   +5 more
core   +1 more source

Laboratory studies evaluating the efficacy of a novel orally administered combination product containing sarolaner, moxidectin and pyrantel (Simparica Trio™) for the treatment and control of flea infestations on dogs

Parasites & Vectors, 2020
Background Five studies were conducted to evaluate a novel oral combination tablet containing sarolaner, moxidectin and pyrantel (Simparica Trio™), for efficacy against induced flea infestations, speed of kill and effects on flea reproduction on dogs ...
Kristina Kryda, Sean P. Mahabir, Lori Carter, William R. Everett, David R. Young, Leon Meyer, Mirjan Thys, Sara Chapin, Susan J. Holzmer, Csilla Becskei   +9 more
doaj   +1 more source

Differential Emodepside Efficacy in Drug-Resistant and Drug-Susceptible <i>Ancylostoma caninum</i> Highlights Variability in Potassium Channel Activity. [PDF]

Trop Med Infect Dis
Multi-anthelmintic resistance in hookworms poses a significant challenge to both human and veterinary health, underscoring the need for novel treatment strategies.
Jackson CA, McKean EL, Hawdon JM.
europepmc   +2 more sources

Responses to the anthelmintics pyrantel and oxantel.

, 2013
A) Electrophysiological recording from an oocyte injected with a 1∶5 Asu-unc-38∶Asu-unc-29 ratio in response to the application of pyrantel (upper trace) and oxantel (lower trace). Pyrantel clearly acts as an agonist at lower concentrations (
Sally M. Williamson (371694), David B. Sattelle (347392), Debra J. Woods (167740), Richard J. Martin (260476), Adrian J. Wolstenholme (347396), Laurence Brown (43103), Tracey Williams (57934), Alan P. Robertson (362793)   +7 more
core   +1 more source