Results 51 to 60 of about 12,602 (203)

N′-[1-(Pyrazin-2-yl)ethylidene]pyrazine-2-carbohydrazide [PDF]

IUCrData, 2018
The title compoud, C11H10N6O, was synthesized by the condensation reaction of pyrazine-2-carbohydrazide with 2-acetylpyrazine in ethanol. The dihedral angle between the pyrazine rings is 4.7 (3)°. In the crystal, aromatic π–π stacking [centroid–centroid separations = 3.606 (5) and 3.671 (5) Å] connect the molecules into stacks propagating in the [010 ...
openaire   +2 more sources

Reconstructed Polyamide Nanolayers via Two‐Stage Interfacial Polymerization Engineering for Precise Ion Sieving

Advanced Science, EarlyView.
A reconstructed polyamide nanofiltration membrane is engineered via a two‐stage interfacial polymerization strategy for lithium extraction from complex brines. Incorporated bidentate quaternary ammonium monomers enable synergistic steric and electrostatic effects within sub‐nanometer channels, achieving 60‐fold lithium enrichment and demonstrating ...
Shuzhen Zhao, Liheng Dai, Feidong Yang, Bowen Li, Pengfei Zhang, Yanyan Liu, Mengyang Hu, Kecheng Guan, Ryosuke Takagi, Hideto Matsuyama   +9 more
wiley   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

From Quinoxaline, Pyrido[2,3-b]pyrazine and Pyrido[3,4-b]pyrazine to Pyrazino-Fused Carbazoles and Carbolines

Molecules, 2018
2,3-Diphenylated quinoxaline, pyrido[2,3-b]pyrazine and 8-bromopyrido[3,4-b]pyrazine were halogenated in deprotometalation-trapping reactions using mixed 2,2,6,6-tetramethyl piperidino-based lithium-zinc combinations in tetrahydrofuran.
Frédéric Lassagne, Timothy Langlais, Elsa Caytan, Emmanuelle Limanton, Ludovic Paquin, Manon Boullard, Coline Courtel, Idriss Curbet, Clément Gédéon, Julien Lebreton, Laurent Picot, Valérie Thiéry, Mohamed Souab, Blandine Baratte, Sandrine Ruchaud, Stéphane Bach, Thierry Roisnel, Florence Mongin   +17 more
doaj   +1 more source

Alternative Translation Initiation in PRKN Delays the Onset of Parkinson's Disease and Offers a Therapeutic Target

Annals of Neurology, EarlyView.
Objective Biallelic variants in PRKN cause autosomal recessive Parkinson's disease (PD) with a median age at onset of 31 years. When evaluating the 16 previously published carriers of a homozygous deletion of Exon 2 from the International Parkinson's Disease and Movement Disorder Society Gene Database (MDSGene) database, the median age at onset is ...
Arian Hach, Katja Lohmann, Manabu Funayama, Poornima J. Menon, Eva‐Juliane Vollstedt, Teresa Kleinz, Hiroyo Yoshino, Suzanne Lesage, Britta Meier, Carolyn M. Sue, Jean‐Christophe Corvol, Alexis Brice, Nobutaka Hattori, Christine Klein, Aleksandar Rakovic   +14 more
wiley   +1 more source

High‐Efficiency and Stable Perovskite Solar Cells Enabled by Halogen‐Free Cosolvent‐Processed Pyrazine‐Based Dopant‐Free Hole Transport Material

EcoMat
The complex molecular structures of electron donor (D)–acceptor (A) polymers provide a wealth of useful hints for producing high power conversion efficiency (PCE) as hole transport materials (HTMs) in perovskite solar cells (PVSCs).
Chetan Lakshman, Hyerin Kim, Bo Hyeon Cho, Donghyun Song, Jeonghyeon Park, Young Yong Kim, Jinhwan Yoon, Sung‐Ho Jin   +7 more
doaj   +1 more source

Design and synthesis new indole-based aromatase/iNOS inhibitors with apoptotic antiproliferative activity

Frontiers in Chemistry
The present study details the design, synthesis, and bio-evaluation of indoles 3–16 as dual inhibitors of aromatase and inducible nitric oxide synthase (iNOS)with antiproliferative activity.
Lamya H. Al-Wahaibi, Hesham A. Abou-Zied, Mostafa H. Abdelrahman, Martha M. Morcoss, Laurent Trembleau, Bahaa G. M. Youssif, Stefan Bräse   +6 more
doaj   +1 more source

Versatile Palladium‐Catalyzed C‐H Arylation of Fluoroarenes with 2‐Chloropyridine Derivatives

Chemistry – A European Journal, EarlyView.
Direct C─H arylation of fluoroarenes with 2‐chloropyridines is enabled by a simple Pd/SPhos system in isopropyl acetate. The method uses inexpensive reactants and shows broad scope and high yields. DFT computations explain reactivity and selectivity.
Federico Belnome, Péter P. Fehér, András Stirling, Csongor G. Németh, Tamás Hergert, György M. Keserű, Péter Ábrányi‐Balogh   +6 more
wiley   +1 more source

Progress on the Synthesis Pathways and Pharmacological Effects of Naturally Occurring Pyrazines

Molecules
As one of the most essential types of heterocyclic compounds, pyrazines have a characteristic smell and taste and have a wide range of commercial applications, especially in the food industry.
Xun Liu, Wenli Quan
doaj   +1 more source

Synthesis of a π‐Extended Phenazine Diimide Derivative and Characterization of Its Closed‐Shell Reduced States

Chemistry – A European Journal, EarlyView.
In this work, the synthesis and characterization of novel π‐extended phenazine diimides is reported. The derivatives undergo differential reduction to a dihydrophenazine or Meisenheimer form depending on the reaction conditions employed. The outcome of this work highlights the paramount importance of structural design in determining the nature of the ...
Francesco Rigodanza, Beatrice Bartolomei, Ilaria Crea, Paolo Costa, Nicola Demitri, Marcella Bonchio, Maurizio Prato, Jacopo Dosso   +7 more
wiley   +1 more source