Results 1 to 10 of about 14,505 (239)

Design, Synthesis, Antimicrobial Activity and Molecular Docking of New 1,2,4-Triazepine, 1,3,4,6-Oxatriazepine and Pyridazino[1,2-a] Pyrimidine Derivatives [PDF]

Pharmaceuticals
Background: Recently, compounds such as pyrimidine, pyridazine, 1,2,4-triazepine, 1,3,4,6-oxatriazepine, pyridazino[1,2-a]pyrimidine, and pyridazino[1,2-c] pyrimidine, as well as their derivatives, have attracted attention due to their diverse biological
Nasser Amri, Ameen Ali Abu-Hashem
doaj   +2 more sources

Synthesis, crystal structure, and in silico molecular docking studies of 4-hydroxy-3,5-dimethoxybenzaldehyde (6-chloropyridazin-3-yl)hydrazone monohydrate [PDF]

Acta Crystallographica Section E: Crystallographic Communications
In the title compound, C13H13ClN4O3·H2O, the organic molecule has an E configuration with regard to the C=N bond of the hydrazone bridge. The phenyl and pyridazine rings subtend a dihedral angle of 2.1 (1)° between their mean planes, while the hydrazone ...
Muhammed Rafi Ummer, M. NizamMohideen, Mohammed Nazrudeen Noorulla, Abubacker Sidhik Moolan Khaja   +3 more
doaj   +2 more sources

Formal [4 + 2] combined ionic and radical approach of vinylogous enaminonitriles to access highly substituted sulfonyl pyridazines [PDF]

Communications Chemistry
Pyridazine derivatives hold significant interest due to their broad applications in pharmaceuticals and materials science, where they serve as valuable scaffolds for bioactive compounds and functional materials.
Chanhyun Jung, Kwanghee Lee, Shanmugam Rajasekar, Ji-Youn Yim, Jaeuk Sim, Young Hee Lee, Jae-Hwan Kwak, Soonsil Hyun, Young Kee Kang, Mayavan Viji, Jae-Kyung Jung   +10 more
doaj   +2 more sources

Development of Pyrimido Pyridazine Analogs through Increased Whole Cell Target Engagement of the Dihydropteroate Synthase Pterin Binding Site in Gram-Negative Bacteria. [PDF]

ACS Infect Dis
Snoke HE, Reeve SM, Dharuman S, Wallace MJ, Loudon VC, Zhao Y, Bowling JJ, Murphy PA, Waddell B, Lee RB, Bulitta JB, Lee RE.   +11 more
europepmc   +2 more sources

Synthesis, crystal structure and DFT study of carbon-yl[3-(dibenzo[<i>b</i>,<i>d</i>]thio-phen-4-yl)-6-(pyridin-2-yl-κ<i>N</i>)pyridazine-κ<i>N</i> ¹]bis-(tri-methyl-phosphane)iron(0). [PDF]

Acta Crystallogr E Crystallogr Commun
Futaki R, Chikaraishi Kasuga N, Hirotsu M.   +2 more
europepmc   +3 more sources

Syntheses, crystal structures and thermal properties of catena-poly[cadmium(II)-di-μ-bromido-μ-pyridazine-κ2N1:N2] and catena-poly[cadmium(II)-di-μ-iodido-μ-pyridazine-κ2N1:N2]

Acta Crystallographica Section E: Crystallographic Communications, 2023
The reactions of cadmium bromide and cadmium iodide with pyridazine (C4H4N2) in ethanol under solvothermal conditions led to the formation of crystals of [CdBr2(pyridazine)]n (1) and [CdI2(pyridazine)]n (2), which were characterized by single-crystal X ...
Christian Näther, Inke Jess
doaj   +1 more source

Synthesis and crystal structure of catena-poly[cobalt(II)-di-μ-chlorido-μ-pyridazine-κ2N1:N2]

Acta Crystallographica Section E: Crystallographic Communications, 2023
The reaction of cobalt dichloride hexahydrate with pyridazine leads to the formation of crystals of the title compound, [CoCl2(C4H4N2)]n. This compound is isotypic to a number of compounds with other divalent metal ions. Its asymmetric unit consists of a
Christian Näther, Inke Jess
doaj   +1 more source

Dinuclear Copper Complex with a Pyridazine-Bridged Octadentate Ligand: Monooxygenase Activity and Characterization of Copper-Oxygen Intermediates. [PDF]

Chemistry
Stüber A, Jurgeleit R, Grimm-Lebsanft B, Buchenau S, Kellner I, Appiarius Y, Näther C, Krahmer J, Ivanović-Burmazović I, Rübhausen M, Naumova MA, Tuczek F.   +11 more
europepmc   +3 more sources

2-[4-(2-Chlorobenzyl)-3-methyl-6-oxo-1,6-dihydropyridazin-1-yl]-N-(4-fluorophenyl)acetamide

IUCrData, 2023
The conformation of the title molecule, C20H17ClFN3O2, is partly determined by an intramolecular C—H...O hydrogen bond, which leads to a dihedral angle of 14.7 (4)° between the fluorobenzene ring and the acetamide group.
Hamza Assila, Issam Ameziane El Hassani, Abderrazzak El Moutaouakil Ala Allah, Abdulsalam Alsubari, Joel T Mague, Youssef Ramli, MHammed Ansar   +6 more
doaj   +1 more source

A One-Pot Approach to Novel Pyridazine C-Nucleosides

Molecules, 2021
The synthesis of glycosides and modified nucleosides represents a wide research field in organic chemistry. The classical methodology is based on coupling reactions between a glycosyl donor and an acceptor.
Flavio Cermola, Serena Vella, Marina DellaGreca, Angela Tuzi, Maria Rosaria Iesce   +4 more
doaj   +1 more source