Results 21 to 30 of about 3,250 (181)

Crystal structure and Hirshfeld surface analysis of 4-(4-methylbenzyl)-6-phenylpyridazin-3(2H)-one

Acta Crystallographica Section E: Crystallographic Communications, 2019
In this paper, we describe the synthesis of a new dihydro-2H-pyridazin-3-one derivative. The molecule, C18H16N2O, is not planar; the benzene and pyridazine rings are twisted with respect to each other, making a dihedral angle of 11.47 (2)°, and the ...
Said Daoui, Emine Berrin Cinar, Fouad El Kalai, Rafik Saddik, Khalid Karrouchi, Noureddine Benchat, Cemile Baydere, Necmi Dege   +7 more
doaj   +1 more source

Speciation‐Controlled C–F Bond Functionalization Enabled by Zwitterionic Pnictinidenes

Angewandte Chemie, EarlyView.
Zwitterionic pnictinidenes turn C–F activation into C–X bond construction, enabling broad defluorinative functionalization of polyfluoro(hetero)arenes under mild conditions. Rather than following a metallomimetic Sb(I)/Sb(III) redox turnover, catalysis is redirected by ligand scrambling into a redox‐neutral manifold, revealing catalyst speciation as a ...
Irene Sánchez‐Sordo, Sergio Fernandez, Selwin Fernando, Diego M. Andrada, Oriol Planas   +4 more
wiley   +2 more sources

Coordination‐Driven Direct C─H Metalation of N‐Heterocycles With a Superbasic Co(II) Amide Co(TMP)2

Angewandte Chemie, EarlyView.
By enabling regioselectivities that are inaccessible with conventional bases, this study introduces a Co(II) amide platform for the deprotonative C─H metalation of sensitive N‐heterocycles. Subsequent interception of the resulting Co(II) intermediates with external oxidants affords a family of sterically congested, TMP‐substituted heterocycles via C─N ...
Na Jin, Manting Mu, Max García‐Melchor, Eva Hevia   +3 more
wiley   +2 more sources

The Effect of Temperature on the Corrosion of Cu/HNO3 in the Presence of Organic Inhibitor: Part-2

International Journal of Electrochemical Science, 2010
The effect of temperature on the corrosion behaviour of copper in 2M nitric acid solution in the presence and absence of 5-(2,6-dichlorobenzyl)-6-methylpyridazin-3(2H)-one (P3) has been investigated by weight loss method.
A. Zarrouk, I. Warad, B. Hammouti, A. Dafali, S.S. Al-Deyab, N. Benchat   +5 more
doaj   +1 more source

catena-Poly[[μ3-hydroxido-tetra-μ2-pyridazine-1:2κ4N:N′;1:3κ2N:N′;2:3κ2N:N′-tetrakis(selenocyanato)-1κN,2κN,3κ2N-trizinc(II)]-μ-cyanido-1:2′κ2C:N]

Acta Crystallographica Section E, 2010
In the crystal structure of the title compound, [Zn3(NCSe)4(OH)(CN)(C4H4N2)4]n one of the two crystallographically independent zinc(II) cations is coordinated by two terminal N-bonded selenocyanato anions and two N atoms of two symmetry-related ...
Thorben Reinert, Jan Boeckmann, Inke Jess, Christian Näther   +3 more
doaj   +1 more source

In Silico Structure-Guided Optimization and Molecular Simulation Studies of 3-Phenoxy-4-(3-trifluoromethylphenyl)pyridazines as Potent Phytoene Desaturase Inhibitors

Molecules, 2021
A series of novel 3-phenoxy-4-(3-trifluoromethylphenyl)pyridazines 2–5 were designed, based on the structure of our previous lead compound 1 through the in silico structure-guided optimization approach. The results showed that some of these new compounds
Lijun Yang, Dawei Wang, Dejun Ma, Di Zhang, Nuo Zhou, Jing Wang, Han Xu, Zhen Xi   +7 more
doaj   +1 more source

trans-Diaquabis(pyridazine-3-carboxylato-κ2N2,O)copper(II)

Acta Crystallographica Section E, 2014
In the title compound, [Cu(C5H3N2O2)2(H2O)2], the CuII ion, located on an inversion center, exhibits an octahedral coordination geometry. The equatorial plane is defined by two trans-related N,O-bidentate pyridazine-3-carboxylate ligands and the axial ...
Aroa Pache, Amaia Iturrospe, Leire San Felices, Santiago Reinoso, Juan M. Gutiérrez-Zorrilla   +4 more
doaj   +1 more source

Polymorphism of 2-(5-benzyl-6-oxo-3-phenyl-1,6-dihydropyridazin-1-yl)acetic acid with two monoclinic modifications: crystal structures and Hirshfeld surface analyses

Acta Crystallographica Section E: Crystallographic Communications, 2020
Two polymorphs of the title compound, C19H16N2O3, were obtained from ethanolic (polymorph I) and methanolic solutions (polymorph II), respectively. Both polymorphs crystallize in the monoclinic system with four formula units per cell and a complete ...
Said Daoui, Cemile Baydere, Tarik Chelfi, Fouad El Kalai, Necmi Dege, Khalid Karrouchi, Noureddine Benchat   +6 more
doaj   +1 more source

The synthesis and antimicrobial activity of 5-aroxy-2,6-dihydro-1H-pyrrolo[3,4-d] pyridazine-1-ones

Журнал органічної та фармацевтичної хімії, 2019
Aim. To develop an effective method for the synthesis of 5-aroxy-2,6-dihydro-1Н-pyrrolo[3,4-d]pyridazine-1-ones as promising objects to be investigated in the context of their antimicrobial activity. Results and discussion.
A. M. Grozav, M. Z. Fedoriv, V. O. Chornous, N. D. Yakovychuk, S. Ye. Deineka, S. V. Kemskyi   +5 more
doaj   +1 more source

Discovery of Novel Pyridazine-Based Cyclooxygenase-2 Inhibitors with a Promising Gastric Safety Profile

Molecules, 2020
Cyclooxygenase-2 (COX-2) is implicated in the development of chronic inflammatory diseases. Recently, pyridazine derivatives have emerged as a novel prototype to develop COX-2 inhibitors.
Abida Khan, Anupama Diwan, Hamdy Kh. Thabet, Mohd Imran, Md. Afroz Bakht   +4 more
doaj   +1 more source