Results 1 to 10 of about 2,940 (138)

Diazo Transfer From Nitrous Oxide Employing Phosphorus Ylides. [PDF]

Angew Chem Int Ed Engl
A phosphorus ylide‐mediated strategy achieves the direct fixation of nitrous oxide (N2O) to access diazo compounds, which after intra‐ or intermolecular trapping, afford N2‐containing organic building blocks. This approach provides an alternative to hazardous diazo‐transfer reagents and establishes N2O fixation as a sustainable methodology.
Yu JK, Ludwig JN, Antoni PW, Tymann D, Hansmann MM.   +4 more
europepmc   +3 more sources

Phytochemical Characterization and Neuropharmacological Assessment of <i>Combretum indicum</i> Methanolic Extract With Integrated Molecular Docking and Dynamics Simulation for Anxiety and Depression Therapy. [PDF]

Food Sci Nutr
Islam Z, Alam MA, Bhuiyan SA, Naher S, Sultana N, Uddin SMN.   +5 more
europepmc   +1 more source

Evaluation of the Insecticidal Activity, Formulation, and Computational Study of Some Hydrazone and Pyridazin-3(2H)-one Derivatives. [PDF]

Chem Biodivers
Ismail MF, Madkour HMF, Ali AK, Hamed MY, Naguib MM, Aly AF.   +5 more
europepmc   +1 more source

Novel Competitive, Nonpeptidic, SARS-CoV‑2 M^pro Inhibitors with Improved Solubility. [PDF]

ACS Med Chem Lett
Sahin Z, Rivera M, Yang Y, Liu K, Sahin GPC, Bacsa J, Pelly SC, Liotta DC.   +7 more
europepmc   +1 more source

Discovery of Sulfonamide Pantothenate Kinase Activators and Elucidation of the Role of Isoform Selectivity in Cellular Pantothenate Kinase Activation. [PDF]

J Med Chem
Coker AL, Tangallapally R, Yun MK, Subramanian C, Jayasinghe T, Miller K, Edwards A, Frank M, Jackowski S, Rock CO, White SW, Lee RE.   +11 more
europepmc   +1 more source

Development of Pyrimido Pyridazine Analogs through Increased Whole Cell Target Engagement of the Dihydropteroate Synthase Pterin Binding Site in Gram-Negative Bacteria. [PDF]

ACS Infect Dis
Snoke HE, Reeve SM, Dharuman S, Wallace MJ, Loudon VC, Zhao Y, Bowling JJ, Murphy PA, Waddell B, Lee RB, Bulitta JB, Lee RE.   +11 more
europepmc   +1 more source

Synthesis, crystal structure and DFT study of carbon-yl[3-(dibenzo[<i>b</i>,<i>d</i>]thio-phen-4-yl)-6-(pyridin-2-yl-κ<i>N</i>)pyridazine-κ<i>N</i> ¹]bis-(tri-methyl-phosphane)iron(0). [PDF]

Acta Crystallogr E Crystallogr Commun
Futaki R, Chikaraishi Kasuga N, Hirotsu M.   +2 more
europepmc   +1 more source

Pyrazofurin Biosynthesis Involves Nonenzymatic Ring Contraction of a Pyridazine Intermediate Triggered by a Rieske Enzyme-Catalyzed Oxygenation. [PDF]

J Am Chem Soc
Zheng Z, Lee YH, Ren D, Liu HW.
europepmc   +1 more source

Shape-Conserving Atom Replacements. [PDF]

Chem Rev
Puriņš M, Elgindy C, Levin MD.
europepmc   +1 more source

Discovery of VU6025733 (AG06827): A Highly Selective, Orally Bioavailable, and Structurally Distinct M₄ Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) with Robust <i>In Vivo</i> Efficacy. [PDF]

ACS Chem Neurosci
Gregro AR, Park C, Long MF, Baker LA, Bollinger KA, Ringuette AE, Peng L, Luscombe VB, Billard NB, Rodriguez AL, Niswender CM, Peng W, Dickerson JW, Rook JM, O'Neill J, Chang S, Boonen HCM, Jensen T, Thomsen MS, Bridges TM, Boutaud O, Conn PJ, Engers DW, Lindsley CW, Temple KJ.   +24 more
europepmc   +1 more source