Results 131 to 140 of about 64,953 (273)

Pesticides and Hypospadias in Southern Brazil: An Ecological Study

Environmental Toxicology, EarlyView.
ABSTRACT Rio Grande do Sul ranks among the Brazilian states with the highest pesticide consumption and one of the highest prevalences of hypospadias, a congenital anomaly often associated with prenatal exposure to endocrine‐disrupting chemicals. We assessed the relationship between prenatal pesticide exposure and hypospadias risk through an ecological ...
Ricardo Rohweder, Márcia Barbian, Juliana da Silva, Nadia Spada Fiori, Lavinia Schuler‐Faccini   +4 more
wiley   +1 more source

Weak hydrogen and halogen bonding in 4-[(2,2-difluoroethoxy)methyl]pyridinium iodide and 4-[(3-chloro-2,2,3,3-tetrafluoropropoxy)methyl]pyridinium iodide

, 2017
To enable a comparison between a C—H...X hydrogen bond and a halogen bond, the structures of two fluorous-substituted pyridinium iodide salts have been determined.
Hsing-Fang Chiang, Yuh-Sheng Wen, Norman Lu, Joseph S. Thrasher, Ling-Kang Liu, Rong-Jyun Wei   +5 more
core   +1 more source

Benign by design: A paradigm shift in cosmetic ingredient development

International Journal of Cosmetic Science, EarlyView.
Benign by design strategies enable the creation of biodegradable cosmetic ingredients, reducing environmental persistence while maintaining the intended biological activity. This work compiles design rules and tools to guide the development of more sustainable molecules for the cosmetics industry.
Sandra Mota, Klaus Kümmerer, Isabel Martins de Almeida, Emília Sousa   +3 more
wiley   +1 more source

Pyridinium-Based Strategy for a Bioorthogonal Conjugation-Assisted Purification Method for Profiling Cell Surface Proteome

Cell surface proteins (CSPs) are valuable targets for therapeutic agents, but achieving highly selective CSP enrichment in cellular physiology remains a technical challenge.
Yongli Li (527489), Tuanjie Zhang (17349385), Fadeng Yang (6481601), Zhuoheng Pan (17349382), Dongyan Yang (284362), Chuan Dai (2087050), Feng Yin (681489), Lizhi Zhu (1608625), Xiaochun Guo (12084664), Rui Wang (52434), Yuhao An (11197503), Zigang Li (606370), Chuan Wan (1400545), Chenshan Lian (8281266)   +13 more
core   +1 more source

Selective photo labeling of tryptophan in N‐acetyl‐L‐tryptophan ethyl ester and peptide WWCNDGR with a diaryl nitrenium ion

Photochemistry and Photobiology, EarlyView.
Visible light photolysis of a N‐(N,N‐diarylaminopyridinium) salt allows for covalent modification of a peptide. Mass spectrometry demonstrates that this procedure selectively labels tryptophan residues. Laser flash photolysis experiments show that bond formation occurs via a diarylnitrenium ion intermediate.
Edward S. Chinn, Yue Li, Abigail M. Joyce, Daniel E. Falvey   +3 more
wiley   +1 more source

Synthesis of highly stabilized ylides from N-[2-(1,3-benzazolylmethyl)]pyridinium salts

, 1990
A series of new stable ylides has been synthesized by the reaction of N-[2-(1,3-benzazolylmethyl)]-pyridinium salts with electrophiles such as carbon disulphide, isothiocyanate derivatives, phenylisocyanate and benzoyl chloride in a two-phase system ...
Álvarez-Builla Gómez, Julio, Novella Robisco, José Luis, Molina Ponce, Andrés, Cuadro Palacios, Ana María, Vaquero López, Juan José, Vaquero López, Juan J.   +5 more
core   +1 more source

Spatially Resolved Metabolomics of Optimal Cutting Temperature (OCT) Compound‐Embedded Tumors

International Journal of Cancer, Volume 159, Issue 12, Page 3038-3048, 15 December 2026.
ABSTRACT Mass spectrometry imaging (MSI) is emerging as a powerful tool for uncovering the distribution of metabolites in the tumor microenvironment and studying tumor metabolism in vivo. To date, MSI of biobanked tissues contextualized by patient data has been limited to peptides, proteins, and glycans—with few examples for metabolites.
Joseph Monaghan, Nicholas Woytowich, Tian Zhao, Kiera Nguyen, Emily Mahony, Julian J. Lum, Kyle D. Duncan   +6 more
wiley   +1 more source

A designer protein binder of KRAS enables exogenous protein degradation

Protein Science, Volume 35, Issue 12, December 2026.
Abstract Targeted protein degradation has emerged as a powerful strategy for modulating intracellular proteins, particularly those lacking traditional small‐molecule binding pockets. While protein‐based degraders expand this approach to undruggable targets, they typically require intracellular expression in target cells, limiting their utility as ...
Aniekan Okon, Keith M. Cheah, Oscar J. Molina, Gabriel Saenz, K. Dane Wittrup, Ronald T. Raines   +5 more
wiley   +1 more source

Synthesis and Photoacoustic Characterization of Amphiphilic Ni(II) Phthalocyanines as Calorimetric References

ChemPhysChem, Volume 27, Issue 21, 12 November 2026.
A series comprised by four nonionic yet amphiphilic octa‐substituted Ni(II) phthalocyanines is introduced. These NiPcs are soluble in both polar organic solvents and aqueous media. A new experimental setup was developed to investigate their photoacoustic efficiency by combining transient absorption and photoacoustic spectroscopy. This approach revealed
Sidharth Thulaseedharan Nair Sailaja, Niek M. M. Aarts, Iván Maisuls, Alexander Hepp, Andreas Faust, Cristian A. Strassert   +5 more
wiley   +1 more source

Preparation of Pyridinium and Diaminocarbonium Barbituric Acid Ylides [PDF]

, 2003
Through NMR experiments of the reaction of barbituric acid with carbodiimide, a general synthetic procedure for the preparation of 5-diaminomethylenebarbiturates (DABA) was developed.
Douelle, Frederic
core