Results 11 to 20 of about 54,906 (269)

Pyridoxal-5′-phosphate-dependent catalytic antibodies [PDF]

Applied Biochemistry and Biotechnology, 2018
Cofactors—i.e., metal ions and coenzymes—extend the catalytic scope of enzymes and might have been among the first biological catalysts. They may be expected to efficiently extend the catalytic potential of antibodies.
Christen, Philipp, Gramatikova, Svetlana
core   +6 more sources

Synthesis and Structure-Activity Relationships of Pyridoxal-6-arylazo-5'-phosphate and Phosphonate Derivatives as P2 Receptor Antagonists. [PDF]

, 1998
Novel analogs of the P2 receptor antagonist pyridoxal-5'-phosphate-6-phenylazo-2',4'-disulfonate (PPADS) were synthesized. Modifications were made through functional group substitution on the sulfophenyl ring and at the phosphate moiety through the ...
Boyer, José L., Burnstock, Geoffrey, Camaioni, Emidio, Harden, T. Kendall, Jacobson, Kenneth A., Ji, Xiao-Duo, Kim, Heaok, Kim, Yong-Chul, King, Brian F., Mohanram, Arvind, Rychkov, Alexei, Wildman, Scott S.P., Yoburn, Joshua, Ziganshin, Airat U.   +13 more
core   +4 more sources

Purine limitation prevents the exogenous pyridoxal 5'-phosphate accumulation of Salmonella enterica yggS mutants. [PDF]

Microbiol Spectr
YggS belongs to the highly conserved pyridoxal 5′-phosphate (PLP) binding protein family (COG0325) that is found in all domains of life. Though no precise biochemical activity or molecular mechanism has been determined for this protein, an involvement in
Ezekiel KS, Downs DM.
europepmc   +2 more sources

Native Microbiome Members of C. elegans Act Synergistically in Biosynthesis of Pyridoxal 5'-Phosphate. [PDF]

Metabolites, 2022
The roles of the healthy microbiome on the host and the relationships between members of the microbiome remain to be fully characterized. Due to the complexity of the interactions between the mammalian microbiome and its host, the use of model organisms ...
Haçariz O, Viau C, Gu X, Xia J.
europepmc   +2 more sources

Three serendipitous pathways in E. coli can bypass a block in pyridoxal‐5′‐phosphate synthesis [PDF]

Molecular Systems Biology, 2010
Bacterial genomes encode hundreds to thousands of enzymes, most of which are specialized for particular functions. However, most enzymes have inefficient promiscuous activities, as well, that generally serve no purpose.
Juhan Kim, Jamie P Kershner, Yehor Novikov, Richard K Shoemaker, Shelley D Copley   +4 more
doaj   +2 more sources

Current Advances on Structure-Function Relationships of Pyridoxal 5′-Phosphate-Dependent Enzymes

Frontiers in Molecular Biosciences, 2019
Pyridoxal 5′-phosphate (PLP) functions as a coenzyme in many enzymatic processes, including decarboxylation, deamination, transamination, racemization, and others.
Qian Han, Jianyong Li
exaly   +3 more sources

Stereoselective Biocatalytic α-Deuteration of L-Amino Acids by a Pyridoxal 5'-Phosphate-Dependent Mannich Cyclase. [PDF]

Chembiochem, 2023
Gao J, Zhou C, Hai Y.
europepmc   +3 more sources

Association between serum pyridoxal 5'-phosphate levels and all-cause, cardiovascular mortality, and cardiovascular disease in adults: a population-based cohort study. [PDF]

Ther Adv Chronic Dis
Xuan C, Liu RH, Zhao C, Li J, Zhou TT, Tian QW, He GW.   +6 more
europepmc   +2 more sources

Discovery and Characterization of Pyridoxal 5'-Phosphate-Dependent Cycloleucine Synthases. [PDF]

J Am Chem Soc
Abad AND, Seshadri K, Ohashi M, Delgadillo DA, de Moraes LS, Nagasawa KK, Liu M, Johnson S, Nelson HM, Tang Y.   +9 more
europepmc   +3 more sources

Effectiveness of Pyridoxal-5'-Phosphate in PNPO Deficiency: A Systematic Review. [PDF]

J Inherit Metab Dis
Stolwijk NN, van Dussen L, Reijnhout ND, Brands MMMG, Jaeger B, Clayton PT, Hollak CEM, Bosch AM.   +7 more
europepmc   +3 more sources