Results 71 to 80 of about 3,050,482 (146)

The Microbiome as a Mirror: Distinguishing Healthy Individuals From Chronic Constipated Patients and Identifying Those With Hidden Psychiatric Burden

Microbiota Medicine Research, Volume 1, Issue 3, Page 91-106, September 2026.
Gut microbiota signatures distinguish chronic constipated patients from healthy individuals, supporting noninvasive diagnostic potential. Despite challenges in identifying psychiatric‐related comorbidities, microbial alterations, particularly in neurotransmitter and inflammatory pathways, lay the groundwork for future companion diagnostics and ...
Hongyan Qi, Ting Yu, Weichen Liu, Ya Jiang, Die Chen, Li Gao, Hui Li, Yurong Tang   +7 more
wiley   +1 more source

Pyridoxine-dependent epilepsy: an under-recognised cause of intractable seizures

, 2012
Pyridoxine-dependent epilepsy (PDE) is a rare autosomal recessive disorder causing intractable seizures in neonates and infants. PDE patients are typically resistant to anti-epileptic treatment but respond to the administration of pyridoxine.
Yeghiazaryan NS, Brigati G, Falsaperla R, Capovilla G, Zara F, Striano P   +5 more
core   +1 more source

Washed Microbiota Transplantation Improves Chronic‐Phase Febrile Infection‐Related Epilepsy Syndrome: The First Case Report With Long‐Term Follow‐Up and Integrated Multi‐Omics Analysis

Microbiota Medicine Research, Volume 1, Issue 3, Page 107-115, September 2026.
ABSTRACT Background Febrile infection‐related epilepsy syndrome (FIRES) is a catastrophic epileptic encephalopathy. Survivors often enter a chronic phase characterized by drug‐resistant epilepsy, cognitive impairment, behavioral and psychiatric symptoms, and long‐term functional disability.
Qianqian Li, Xiao Ding, Sheng Zhang, Faming Zhang   +3 more
wiley   +1 more source

Beneficial outcome of early dietary lysine restriction as an adjunct to pyridoxine therapy in a child with pyridoxine dependant epilepsy due to Antiquitin deficiency

JIMD Reports, 2020
Pyridoxine‐dependent epilepsy (PDE) is a potentially treatable vitamin‐responsive epileptic encephalopathy. The most prevalent form of PDE is due to an underlying genetic defect in ALDH7A1 encoding Antiquitin (ATQ), an enzyme with α‐aminoadipic ...
Maina P. Kava, Leah Bryant, Peter Rowe, Barry Lewis, Lawrence Greed, Shanti Balasubramaniam   +5 more
doaj   +1 more source

The gut microbiome organ

iMeta, Volume 5, Issue 4, August 2026.
The gut microbiome can be conceptualized as a distributed organ‐like functional system with spatially structured organization, broad biochemical capacity, and continuous bidirectional communication with the host. By transforming dietary, host‐derived, and environmental substrates into bioactive metabolites with endocrine‐like, immunomodulatory, and ...
Yang Bi, Weibin Song, Maria Glymenaki, Jie Hu, Xiru Li, Heng Huang, Yousong Peng, Shuaishuai Ni, Ornuma Haonon, Zhu Liu, Krai Daowtak, Xiaotao Shen, Huadong Peng, Jutarop Phetcharaburanin, Huiru Tang, Yulan Wang, Jia V. Li, Mizu Jiang, Nick Powell, Victor W. Zhong, Elaine Holmes, Yunlei Xianyu, Zhigang Liu   +22 more
wiley   +1 more source

Rethinking GABAergic therapy in neonatal seizures: Beyond Scylla and Charybdis

Epilepsia Open, Volume 11, Issue 5, Page 1886-1887, October 2026.
Raffaele Falsaperla, Vincenzo Sortino, Georgia Ramantani   +2 more
wiley   +1 more source

Astrocytes in Genetic Epilepsies: Supporting Actor or Key Player?

Journal of Neuroscience Research, Volume 104, Issue 8, August 2026.
Astrocytes contribute to the pathophysiology of acquired epilepsy. However, less is known about their contribution to genetic epilepsy syndromes which often exhibit frequent comorbidity with neurodevelopmental and psychiatric disorders. Epileptic seizures are also frequently present in neurodevelopmental disorders.
Jenny Lange, Erica Zhao, Ellie O'Connell, Olivia Gillham, Amy McTague   +4 more
wiley   +1 more source

Phenotypic Variability of Pyridoxine-Dependent Epilepsy

, 2019
Pyridoxine-dependent epilepsy (PDE) is a rare autosomal recessive disorder characterized by seizures in neonates or infants, which is unresponsive to antiepileptic drugs but controlled by pyridoxine.
Ülgenalp, Ayfer, Usluer, Esra, Erçal, Derya   +2 more
core  

Current diagnosis and treatment of pyridoxine dependent epilepsy due to antiqutin deficiency [PDF]

, 2016
Drgawki pirydoksynozależne (pyridoxine-dependent epilepsy – PDE) to rzadko występująca encefalopatia padaczkowa uwarunkowana autosomalnie recesywnie. Charakteryzuje się uporczywymi, nawracającymi drgawkami u noworodków i niemowląt, nieodpowiadającymi na ...
Dariusz Rokicki, Wesół-Kucharska, Dorota, Dorota Wesół-Kucharska, Rokicki, Dariusz, Rokicki, Dariusz; Klinika Pediatrii, Żywienia i Chorób Metabolicznych, Instytut "Pomnik – Centrum Zdrowia Dziecka" w Warszawie, Wesół-Kucharska, Dorota; Klinika Pediatrii, Żywienia i Chorób Metabolicznych, Instytut "Pomnik – Centrum Zdrowia Dziecka" w Warszawie   +5 more
core   +1 more source

Do We Need to Monitor B‐Vitamins and Homocysteine During Initiation of Foslevodopa/Foscarbidopa Therapy?

Movement Disorders, Volume 41, Issue 9, Page 2535-2537, September 2026.
Aida Shaghaghi‐Zadeh, Matthias Höllerhage, Florian Wegner, Lan Ye, Ishana Schneidereit, Tobias Hegelmaier, Rebecca Jacob, Christoph Schrader, Martin Klietz   +8 more
wiley   +1 more source