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Seasonal malaria chemoprevention and mutations in <i>Pfdhfr</i> and <i>Pfdhps</i> genes in children in the health district of Nanoro, Burkina Faso. [PDF]
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The multifaceted antineoplastic role of pyrimethamine against human malignancies
IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology, 2021Cancer accounted for nearly 10 million deaths in 2020 and is the second leading cause of death worldwide. The chemotherapeutic agents that are in clinical practice possess a broad range of severe adverse effects towards vital organs which emphasizes the ...
Shanaya Ramchandani+6 more
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Chemoprevention by Pyrimethamine
Immunopharmacology and Immunotoxicology, 2005The goal of the current research was to investigate the chemopreventive potency of an antimalaria drug, pyrimethamine, in in vitro conditions. The fibrosarcoma (WEHI-164) cell line was used for evaluating cytotoxicity, matrix metalloproteinase 2 (MMP-2) activity, and apoptosis. Pyrimethamine and methotrexate were used at concentrations of 0-8 microg/ml
Mohammad Reza Khorramizadeh+2 more
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The Lancet, 1982
Field studies were conducted in Kisumu, Kenya, to assess the susceptibility of local strains of Plasmodium falciparum to pyrimethamine alone (by a standard 7-day in-vivo test and a 48 h in-vitro field test) and to sulfadoxine-pyrimethamine (by a 7-day in-vivo test).
Shemey Chemangey-Masaba+3 more
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Field studies were conducted in Kisumu, Kenya, to assess the susceptibility of local strains of Plasmodium falciparum to pyrimethamine alone (by a standard 7-day in-vivo test and a 48 h in-vitro field test) and to sulfadoxine-pyrimethamine (by a 7-day in-vivo test).
Shemey Chemangey-Masaba+3 more
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Treatment of vivax malaria with sulfadoxine-pyrimethamine and with pyrimethamine alone
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1979The effect of pyrimethamine and the combination of pyrimethamine-sulfadoxine (Fansidar) upon the termination of the acute attack of vivax malaria was studied in Thailand. Pyrimethamine was found to be ineffective, providing clearance of parasitaemia in only two of six patients by the end of seven days following treatment.
C. Teerakiartkamjorn+4 more
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