Results 251 to 260 of about 42,597 (297)
Some of the next articles are maybe not open access.
Related searches:
Related searches:
The multifaceted antineoplastic role of pyrimethamine against human malignancies
IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology, 2021Cancer accounted for nearly 10 million deaths in 2020 and is the second leading cause of death worldwide. The chemotherapeutic agents that are in clinical practice possess a broad range of severe adverse effects towards vital organs which emphasizes the ...
Shanaya Ramchandani +6 more
semanticscholar +1 more source
Chemoprevention by Pyrimethamine
Immunopharmacology and Immunotoxicology, 2005The goal of the current research was to investigate the chemopreventive potency of an antimalaria drug, pyrimethamine, in in vitro conditions. The fibrosarcoma (WEHI-164) cell line was used for evaluating cytotoxicity, matrix metalloproteinase 2 (MMP-2) activity, and apoptosis. Pyrimethamine and methotrexate were used at concentrations of 0-8 microg/ml
Mohammad Reza Khorramizadeh +2 more
openaire +3 more sources
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2019
Intermittent preventive treatment (IPT) with sulphadoxine‐pyrimethamine (SP) is recommended for preventing maternal and fetal effects of malaria in pregnancy. Increasing parasite resistance to SP has necessitated the search for an alternative medication.
Atinuke O. Olaleye +4 more
semanticscholar +1 more source
Intermittent preventive treatment (IPT) with sulphadoxine‐pyrimethamine (SP) is recommended for preventing maternal and fetal effects of malaria in pregnancy. Increasing parasite resistance to SP has necessitated the search for an alternative medication.
Atinuke O. Olaleye +4 more
semanticscholar +1 more source
The Lancet, 1982
Field studies were conducted in Kisumu, Kenya, to assess the susceptibility of local strains of Plasmodium falciparum to pyrimethamine alone (by a standard 7-day in-vivo test and a 48 h in-vitro field test) and to sulfadoxine-pyrimethamine (by a 7-day in-vivo test).
Shemey Chemangey-Masaba +3 more
openaire +3 more sources
Field studies were conducted in Kisumu, Kenya, to assess the susceptibility of local strains of Plasmodium falciparum to pyrimethamine alone (by a standard 7-day in-vivo test and a 48 h in-vitro field test) and to sulfadoxine-pyrimethamine (by a 7-day in-vivo test).
Shemey Chemangey-Masaba +3 more
openaire +3 more sources
Treatment of vivax malaria with sulfadoxine-pyrimethamine and with pyrimethamine alone
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1979The effect of pyrimethamine and the combination of pyrimethamine-sulfadoxine (Fansidar) upon the termination of the acute attack of vivax malaria was studied in Thailand. Pyrimethamine was found to be ineffective, providing clearance of parasitaemia in only two of six patients by the end of seven days following treatment.
C. Teerakiartkamjorn +4 more
openaire +3 more sources
Hyperpigmentation Due to Pyrimethamine Use
The Journal of Dermatology, 2002AbstractPyrimethamine is used for the treatment of toxoplasmosis and the prophylaxis of malaria. Among the well‐documented side effects are megaloblastic anemia, leukopenia, thrombopenia, rash, vomiting, and diarrhea. Hyperpigmentation is a very rare side effect.
ENGİN, AYNUR +5 more
openaire +4 more sources
Anti-Cancer Drugs, 2019
Pyrimethamine has been used principally to treat infections from protozoan parasites. Although previous studies have shown that pyrimethamine exhibited anticancer activity by inducing cellular apoptosis, there are none that show that pyrimethamine ...
Ya Liu +3 more
semanticscholar +1 more source
Pyrimethamine has been used principally to treat infections from protozoan parasites. Although previous studies have shown that pyrimethamine exhibited anticancer activity by inducing cellular apoptosis, there are none that show that pyrimethamine ...
Ya Liu +3 more
semanticscholar +1 more source
Biopharmaceutics & Drug Disposition, 1986
AbstractWe have investigated the plasma pharmacokinetics and mass fate in mice, of pyrimethamine administered as either the base or as the poorly soluble pamoate salt, in each case by the intraperitoneal (i.p.) and subcutanous (s.c.) routes. Following the administration of pyrimethamine base (i.p.
Geoffrey Edwards +4 more
openaire +3 more sources
AbstractWe have investigated the plasma pharmacokinetics and mass fate in mice, of pyrimethamine administered as either the base or as the poorly soluble pamoate salt, in each case by the intraperitoneal (i.p.) and subcutanous (s.c.) routes. Following the administration of pyrimethamine base (i.p.
Geoffrey Edwards +4 more
openaire +3 more sources