Spectroscopic Investigation of Na+‑Dependent Conformational Changes of a Cyclobutane Pyrimidine Dimer-Repairing Deoxyribozyme [PDF]
ACS Omega, 2023 Tatsuya Iwata +3 more
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Structural basis of cyclobutane pyrimidine dimer recognition by UV-DDB in the nucleosome [PDF]
Nature CommunicationsIn mammalian global genomic nucleotide excision repair, UV-DDB plays a central role in recognizing DNA lesions, such as 6-4 photoproducts and cyclobutane pyrimidine dimers, within chromatin.
Syota Matsumoto +10 more
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Elevated pyrimidine dimer formation at distinct genomic bases underlies promoter mutation hotspots in UV-exposed cancers. [PDF]
PLoS Genetics, 2018 Sequencing of whole cancer genomes has revealed an abundance of recurrent mutations in gene-regulatory promoter regions, in particular in melanoma where strong mutation hotspots are observed adjacent to ETS-family transcription factor (TF) binding sites.
Kerryn Elliott +7 more
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Antarctic Microalga Chlamydomonas sp. ICE-L Cryptochrome CiCRY-DASH1 Mediates Efficient DNA Photorepair of UV-Induced Cyclobutane Pyrimidine Dimer and 6-4 Photoproducts [PDF]
Marine DrugsCryptochromes (CRYs) are a conserved class of blue light and near-ultraviolet light receptors that regulate diverse processes, including photomorphogenesis in plants.
Zhou Zheng +5 more
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The effect of flanking bases on direct and triplet sensitized cyclobutane pyrimidine dimer formation in DNA depends on the dipyrimidine, wavelength and the photosensitizer [PDF]
Nucleic Acids Res, 2021 Chen Lǚ +2 more
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Chrysanthemum Morifolium Extract And Ascorbic Acid-2-Glucoside (AA2G) Blend Inhibits UVA-Induced Delayed Cyclobutane Pyrimidine Dimer (CPD) Production In Melanocytes [PDF]
Clinical, Cosmetic and Investigational Dermatology, 2019 Sunghan Yim,1 Jeesun Lee,2 Hae Jo,2 Jeff Scholten,1 Ryan Willingham,3 Jim Nicoll,3 Sudhir M Baswan4 1Analytical Sciences R&D, Amway Corporation, Ada, MI, USA; 2Asia Innovation Center, Global Discovery R&D, Amway Corporation, Seoul, South Korea ...
Yim S +6 more
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Poaceae plants transfer cyclobutane pyrimidine dimer photolyase to chloroplasts for ultraviolet-B resistance [PDF]
Plant PhysiolMomo Otake +5 more
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The epigenetic DNA modification 5-carboxylcytosine promotes high levels of cyclobutane pyrimidine dimer formation upon UVB irradiation [PDF]
Genome Instab Dis, 2021 Sang‐In Kim, Gerd P. Pfeifer
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3.1 Å structure of yeast RNA polymerase II elongation complex stalled at a cyclobutane pyrimidine dimer lesion solved using streptavidin affinity grids [PDF]
J Struct Biol, 2019 Indrajit Lahiri +6 more
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Identification of Cyclobutane Pyrimidine Dimer-Responsive Genes Using UVB-Irradiated Human Keratinocytes Transfected with In Vitro-Synthesized Photolyase mRNA. [PDF]
PLoS ONE, 2015 Major biological effects of UVB are attributed to cyclobutane pyrimidine dimers (CPDs), the most common photolesions formed on DNA. To investigate the contribution of CPDs to UVB-induced changes of gene expression, a model system was established by ...
Gábor Boros +10 more
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