Results 151 to 160 of about 14,669 (203)

PYRIMIDINE DIMER FORMATION IN HUMAN SKIN

Photochemistry and Photobiology, 1987
AbstractCyclobutyl pyrimidine dimers are major photoproducts formed upon irradiation of DNA with ultraviolet light. We have developed a method for detecting as few as one pyrimidine dimer per million bases in about 50 ng of non‐radioactive DNA, and have used this method to quantitate dimer yields in human skin DNA exposed in situ to UV.
S E, Freeman, R W, Gange, J C, Sutherland, B M, Sutherland   +3 more
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Biological consequences of cyclobutane pyrimidine dimers

Journal of Photochemistry and Photobiology B: Biology, 2001
In the skin many molecules may absorb ultraviolet (UV) radiation upon exposure. In particular, cellular DNA strongly absorbs shorter wavelength solar UV radiation, resulting in various types of DNA damage. Among the DNA photoproducts produced the cyclobutane pyrimidine dimers (CPDs) are predominant.
Vink, A.A., Roza, L.
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Pyrimidine dimer splitting in covalently linked dimer—arylamine systems

Journal of Photochemistry and Photobiology B: Biology, 1992
Cyclobutadipyrimidines (pyrimidine dimers) undergo photosplitting which is sensitized by electron donors. We prepared a series of compounds in which a dimer is directly linked to an arylamine, which acts as sensitizer for dimer splitting. Two diastereomers of the dimer-arylamine exhibited very different splitting efficiencies.
S T, Kim, S D, Rose
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Repair of DNA‐containing pyrimidine dimers

The FASEB Journal, 1988
Ultraviolet light‐induced pyrimidine dimers in DNA are recognized and repaired by a number of unique cellular surveillance systems. The most direct biochemical mechanism responding to this kind of geno‐toxicity involves direct photoreversal by flavin enzymes that specifically monomerize pyrimidine:pyrimidine dimers monophotonically
L, Grossman, P R, Caron, S J, Mazur, E Y, Oh   +3 more
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Are pyrimidine dimers Non-Instructive lesions?

Molecular and General Genetics MGG, 1981
Published data from yeast and E. coli show that base substitution induced by UV in pyrimidine-pyrimidine sequences is not random, and suggest that fidelity of DNA replication is not entirely lost during transdimer synthesis. These observations question whether cyclobutane pyrimidine dimers are truly non-instructive lesions.
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Cleavage of pyrimidine dimers in specific DNA sequences by a pyrimidine dimer DNA-glycosylase of M. luteus

Nature, 1980
Pyrimidine dimer formation in response to UV radiation is governed by the thymine content of the potential dimer and the two flanking nucleotides. An enzymatic activity can be purified from Micrococcus luteus that cleaves the N-glycosyl bond between the 5' pyrimidine of a dimer and the corresponding sugar without rupture of a phosphodiester bond.
W A, Haseltine, L K, Gordon, C P, Lindan, R H, Grafstrom, N L, Shaper, L, Grossman   +5 more
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Mechanism of photosensitized dimerization of pyrimidines

Chemical Communications (London), 1968
Excited sensiter molecule in triplet state interacting with the target molecule (thymine) tranfers its triplet state energy to the latter. Two excited target molecule dimerize.
Kornhauser, Andrija, Herak, Janko, Trinajstić, Nenad   +2 more
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Photosensitized splitting of pyrimidine dimers by indole derivatives

Biochemical and Biophysical Research Communications, 1971
Abstract Excitation of tryptophan and 5-hydroxytryptophan at wavelengths longer than 290 and 310 nm, respectively, in the presence of pyrimidine dimers leads to a sensitized splitting of these dimers. The reaction is more efficient in frozen than in fluid aqueous solutions. The fluorescence of tryptophan and 5-hydroxytryptophan is quenched by thymine
C, Helene, M, Charlier
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Pyrimidine Dimers: Effect of Temperature on Photoinduction

Science, 1966
Ultraviolet-induced pyrimidine dimer formation in DNA and polyuridylic acid was inhibited on irradiation at 77°K. Enhancement of thymine dimer formation in solutions of DNA occurred upon addition of ethylene glycol. Low temperature measurements of absorbance of polyuridylic acid at low temperature showed that no significant alteration of the residues ...
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PYRIMIDINE DIMER FORMATION IN ULTRAVIOLET IRRADIATED TMV‐RNA

Photochemistry and Photobiology, 1967
Abstract— The formation of pyrimidine dimers on ultraviolet irradiation of TMV‐RNA in water is demonstrated in the region from 254 nm to 302 nm. No dimer is present in either unirradiated E. coli ribosomal RNA or TMV‐RNA. Dimer formation was also examined in TMV‐RNA irradiated in the presence of 5times10‐6 M proflavin, in high salt, on dry ice, and in ...
V, Merriam, M P, Gordon
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