Bacteriophage-related epigenetic natural and non-natural pyrimidine nucleotides and their influence on transcription with T7 RNA polymerase. [PDF]
Commun ChemDNA modifications on pyrimidine nucleobases play diverse roles in biology such as protection of bacteriophage DNA from enzymatic cleavage, however, their role in the regulation of transcription is underexplored.
Gracias F +3 more
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A universal polyphosphate kinase: PPK2c of Ralstonia eutropha accepts purine and pyrimidine nucleotides including uridine diphosphate. [PDF]
Appl Microbiol Biotechnol, 2020 Polyphosphosphate kinases (PPKs) catalyse the reversible transfer of the γ-phosphate group of a nucleoside-triphosphate to a growing chain of polyphosphate. Most known PPKs are specific for ATP, but some can also use GTP as a phosphate donor.
Hildenbrand JC, Teleki A, Jendrossek D.
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Re-Discovery of Pyrimidine Salvage as Target in Cancer Therapy
Cells, 2022 Nucleotides are synthesized through two distinct pathways: de novo synthesis and nucleoside salvage. Whereas the de novo pathway synthesizes nucleotides from amino acids and glucose, the salvage pathway recovers nucleosides or bases formed during DNA or ...
Melanie Walter, Patrick Herr
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Structure-Activity Relationship of Purine and Pyrimidine Nucleotides as Ecto-5'-Nucleotidase (CD73) Inhibitors. [PDF]
J Med Chem, 2019 Cluster of differentiation 73 (CD73) converts adenosine 5'-monophosphate to immunosuppressive adenosine, and its inhibition was proposed as a new strategy for cancer treatment. We synthesized 5'- O-[(phosphonomethyl)phosphonic acid] derivatives of purine
Junker A +14 more
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Repair and DNA Polymerase Bypass of Clickable Pyrimidine Nucleotides [PDF]
BiomoleculesClickable nucleosides, most often 5-ethynyl-2′-deoxyuridine (EtU), are widely used in studies of DNA replication in living cells and in DNA functionalization for bionanotechology applications.
Endutkin A +6 more
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Crystalizing the genetic code [PDF]
arXiv, 2000 New developments are presented in the framework of the model introduced by the authors in refs. [1,2] and in which nucleotides as well as codons are classified in crystal bases of the quantum group U_q(sl(2)+sl(2)) in the limit q -> 0.
Frappat, L., Sciarrino, A., Sorba, P.
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Pyrimidine Nucleotides Containing a (S)-Methanocarba Ring as P2Y6 Receptor Agonists. [PDF]
Medchemcomm, 2017 Both agonists and antagonists of the UDP-activated P2Y6 receptor (P2Y6R) have been proposed for therapeutic use, in conditions such as cancer, inflammation, neurodegeneration and diabetes.
Toti KS +7 more
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Dephosphorylation of Pyrimidine Nucleotides in the Soluble Fraction of Homogenates from Normal and Regenerating Rat Liver [PDF]
, 1967 The dephosphorylation of the pyrimidine nucleotides UMP, CMP, dUMP, dCMP, and dTMP was determined in the soluble fraction of homogenates from normal rat liver and from regenerating liver during an 8-day period after partial hepatectomy.
Per Fritzson
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PLoS ONE, 2013 As second messengers, the cyclic purine nucleotides adenosine 3',5'-cyclic monophosphate (cAMP) and guanosine 3',5'-cyclic monophosphate (cGMP) play an essential role in intracellular signaling.
Daniel Reinecke +3 more
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A p53-dependent S-phase checkpoint helps to protect cells from DNA damage in response to starvation for pyrimidine nucleotides [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1998 Normal mammalian cells arrest primarily in G1 in response to N-(phosphonacetyl)-L-aspartate (PALA), which starves them for pyrimidine nucleotides, and do not generate or tolerate amplification of the CAD gene, which confers resistance to PALA.
Munna L. Agarwal +5 more
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