Research progress of dCTP pyrophosphatase 1 regulating nucleotide metabolism and phenotype of tumor cells [PDF]
Jichu yixue yu linchuang, 2021 Deoxycytidine triphosphate pyrophosphatase 1(dCTP pyrophosphatase 1, DCTPP1) is a newly discovered pyrophosphatase targeting deoxycytidine triphosphate (dCTP).
LI Jing, ZHANG Mei-gui, BAI Zhong-tian
doaj
Frontiers in Plant Science, 2021 The enzyme phosphoribosyl pyrophosphate synthase (PRPS) catalyzes the conversion of ribose 5-phosphate into phosphoribosyl diphosphate; the latter is a precursor of purine and pyrimidine nucleotides.
Sera Jung +7 more
doaj +1 more source
Statistical distributions of sequencing by synthesis with probabilistic nucleotide incorporation [PDF]
Journal of Computational Biology. June 2009, 16(6): 817-827, 2014 Sequencing by synthesis is used in many next-generation DNA sequencing technologies. Some of the technologies, especially those exploring the principle of single-molecule sequencing, allow incomplete nucleotide incorporation in each cycle. We derive statistical distributions for sequencing by synthesis by taking into account the possibility that ...
arxiv +1 more source
Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration
Advanced Science, EarlyView.The article explores a novel therapeutic strategy for cardiac regeneration by targeting miRNA‐1a and miRNA‐15b. Combinatorial inhibition of miR‐1a and miR‐15b enhances cardiomyocyte proliferation, improves heart function, and reduces fibrosis in myocardial infarction models.
Ting Yuan +16 more
wiley +1 more source
Lethal Mutagenesis of Picornaviruses with N-6-Modified Purine Nucleoside Analogues [PDF]
, 2008 RNA viruses exhibit extraordinarily high mutation rates during genome replication. Nonnatural ribonucleosides that can increase the mutation rate of RNA viruses by acting as ambiguous substrates during replication have been explored as antiviral agents ...
Barr, Eric W. +11 more
core +4 more sources
HDAC6 and USP9X Control Glutamine Metabolism by Stabilizing GS to Promote Glioblastoma Tumorigenesis
Advanced Science, EarlyView.Glioblastoma (GBM) growth relies on glutamine synthetase (GS), which is stabilized by histone deacetylase 6 (HDAC6) and deubiquitinated by ubiquitin‐specific peptidase 9, X‐linked (USP9X). HDAC6 promotes GS deacetylation, while USP9X removes its K48‐linked polyubiquitination, enhancing GS stability.
Go Woon Kim +9 more
wiley +1 more source
Formation of Platinum Blues by Pyrimidine Nucleotides
Zeitschrift für Naturforschung C, 1979 Abstract The formation is reported of platinum blues by 5′-CMP and by 5′-UMP.
David M. L. Goodgame, Ian Jeeves
openaire +2 more sources
Pyrimidine nucleotide metabolism in rat hepatocytes: evidence for compartmentation of nucleotide pools [PDF]
Biochemical Journal, 1993 Pyrimidine nucleotide metabolism in rat hepatocytes was studied by measurement of the labelling kinetics of the various intermediates after double labelling with [14C]orotic acid and [3H]cytidine, the precursors for the de novo and the salvage pathways respectively.
W R Pels Rijcken +3 more
openaire +3 more sources
Purine-pyrimidine symmetry, determinative degree and DNA [PDF]
arXiv, 2000 Various symmetries connected with purine-pyrimidine content of DNA sequences are studied in terms of the intruduced determinative degree, a new characteristics of nucleotide which is connected with codon usage. A numerological explanation of CG pressure is proposed. A classification of DNA sequences is given.
arxiv
Metabolic alterations in human pulmonary artery smooth muscle cells treated with PDGF‐BB
Animal Models and Experimental Medicine, EarlyView.Metabolic abnormalities are considered to play a key regulatory role in vascular remodeling of pulmonary arterial hypertension. We analyzed the metabolome in the culture supernatants of human pulmonary artery smooth muscle cells (PASMC) during the malignant proliferation phenotype transition via a targeted metabolomics method. Significant and extensive
Meng‐Jie Zhang +9 more
wiley +1 more source