Results 141 to 150 of about 643,096 (374)

Coordination Chemistry of Phosphate Groups in Systems Including Copper(II) Ions, Phosphoethanolamine and Pyrimidine Nucleotides. [PDF]

Int J Mol Sci, 2022
Gabryel-Skrodzka M, Nowak M, Teubert A, Jastrzab R.   +3 more
europepmc   +1 more source

Harnessing nucleotide metabolism and immunity in cancer: a tumour microenvironment perspective. [PDF]

FEBS J
This review explores how changes in nucleotide metabolism affect the tumour microenvironment and immune responses in cancer. Here, we discuss the dual role of nucleotide metabolism in promoting cancer cell growth and shaping immune suppression. We highlight how therapies targeting nucleotide pathways can enhance immunotherapy efficacy, offering new ...
Suleiman H, Emerson A, Wilson PM, Mulligan KA, Ladner RD, LaBonte MJ.   +5 more
europepmc   +2 more sources

Plasma membrane-located purine nucleotide transport proteins are key components for host exploitation by microsporidian intracellular parasites.

PLoS Pathogens, 2014
Microsporidia are obligate intracellular parasites of most animal groups including humans, but despite their significant economic and medical importance there are major gaps in our understanding of how they exploit infected host cells.
Eva Heinz, Christian Hacker, Paul Dean, John Mifsud, Alina V Goldberg, Tom A Williams, Sirintra Nakjang, Alison Gregory, Robert P Hirt, John M Lucocq, Edmund R S Kunji, T Martin Embley   +11 more
doaj   +1 more source

Autophagy-dependent ribosomal RNA degradation is essential for maintaining nucleotide homeostasis during C. elegans development

eLife, 2018
Ribosome degradation through the autophagy-lysosome pathway is crucial for cell survival during nutrient starvation, but whether it occurs under normal growth conditions and contributes to animal physiology remains unaddressed.
Yubing Liu, Wei Zou, Peiguo Yang, Li Wang, Yan Ma, Hong Zhang, Xiaochen Wang   +6 more
doaj   +1 more source

1H and 15N NMR investigation of the interaction of pyrimidine nucleotides with ribonuclease A.

European Journal of Biochemistry, 1985
Extensive 1H and 15H NMR investigations of the nucleotide moieties capable of hydrogen bonding to ribonuclease A were carried out in order to gain more detailed information on the specificity of nucleotide-enzyme interaction.
U. Hahn, R. Desai-Hahn, H. Rüterjans
semanticscholar   +1 more source

Advances in Isotope Labeling for Solution Nucleic Acid Nuclear Magnetic Resonance Spectroscopy

ChemPlusChem, EarlyView.
Recent advances in the field of nucleic acid nuclear magnetic resonance (NMR) are presented. Stable isotope labeling protocols and new approaches to segmentally label nucleic acid with NMR‐active residues are summarized. The novel methods will have a strong impact on the future of nucleic acid NMR and the characterization of structure and dynamics of ...
Stefan Hilber, Solomon Kojo Attionu, Theodore Kwaku Dayie, Christoph Kreutz   +3 more
wiley   +1 more source

Epigenetic Pyrimidine Nucleotides in Competition with Natural dNTPs as Substrates for Diverse DNA Polymerases. [PDF]

ACS Chem Biol, 2022
Pospíšil Š, Panattoni A, Gracias F, Sýkorová V, Hausnerová VV, Vítovská D, Šanderová H, Krásný L, Hocek M.   +8 more
europepmc   +1 more source

A simple stochastic model to describe the evolution over time of core genome SNP GC content in prokaryotes [PDF]

arXiv, 2019
Genomes in living organisms consist of the nucleotides adenine (A), guanine (G), cytosine (C) and thymine (T). All prokaryotes have genomes consisting of double-stranded DNA, where the A's and G's (purines) of one strand bind respectively to the T's and C's (pyrimidines) of the other. As such, the number of A's on one strand nearly equals the number of
arxiv  

A Simple Analysis of Purine and Pyrimidine Nucleotides in Plant Cells by High-Performance Liquid Chromatography

, 1987
Purine and pyrimidine nucleotides, extracted from cultured plant cells with 6 % perchloric acid, were separated directly with HPLC using anion-exchange Shimpack WAX -1 column.
H. Ashihara, Kaori Mitsui, T. Ukaji
semanticscholar   +1 more source

Implementing Pre‐Emptive Pharmacogenetics: Impact of Early Pharmacogenetic Screening in a Pediatric Oncology Cohort of 1,151 Subjects

Clinical Pharmacology &Therapeutics, EarlyView.
In pediatric oncology, pharmacogenetic guidelines are underutilized and the potential impact of pre‐emptive pharmacogenetic screening remains largely unexplored despite this field's need for individualized approaches. While comprehensive pharmacogenetic guidelines are not yet available for all anticancer drugs, evidence‐based recommendations exist for ...
Emma C. Bernsen, Eugène T.P. Verwiel, Maaike van der Lee, Jesse J. Swen, Marcel Santoso, Leiah J. Brigitha, Rick Admiraal, Bastiaan B.J. Tops, Alwin D.R. Huitema, Patrick Kemmeren, Jayne Y. Hehir‐Kwa, Lidwien M. Hanff, Meta H.M. Diekstra   +12 more
wiley   +1 more source