Results 11 to 20 of about 643,096 (374)
Efficacy of neuroprotective treatment including pyrimidine nucleotides in secondary uveitic glaucoma
Journal of Ophthalmology, 2018 Background: Secondary glaucoma is found in 18% to 38% of patients with uveitis, and is one of the most severe uveitic complications. The glaucomatous process is characterized by the progressive optic nerve neuropathy. The lack of efficacy of conventional
V. V. Savko, V. V. Savko Jnr
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Purine but Not Pyrimidine Nucleotides Support Rotation of F1-ATPase [PDF]
Journal of Biological Chemistry, 2001 The binding change model for the F(1)-ATPase predicts that its rotation is intimately correlated with the changes in the affinities of the three catalytic sites for nucleotides. If so, subtle differences in the nucleotide structure may have pronounced effects on rotation. Here we show by single-molecule imaging that purine nucleotides ATP, GTP, and ITP
Masasuke Yoshida +8 more
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Catabolism of Pyrimidine Nucleotides in the Deep-sea Tube WormRiftia pachyptila [PDF]
Journal of Biological Chemistry, 2002 The present study describes the distribution and properties of enzymes of the catabolic pathway of pyrimidine nucleotides in Riftia pachyptila, a tubeworm living around deep-sea hydrothermal vents and known to be involved in a highly specialized ...
Zoran Minić +3 more
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Characterization of P2 receptors for purine and pyrimidine nucleotides in human placental cotyledons [PDF]
British Journal of Pharmacology, 1997 Vera Ralevic +3 more
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Chemistry, 2023 A styrylpyridine-containing cyclophane with diethylenetriamine linkers is presented as a host system whose association with representative nucleotides was examined with photometric and fluorimetric titrations.
Julika Schlosser +3 more
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Frontiers in Plant Science, 2023 In Arabidopsis seedlings, inhibition of aspartate transcarbamoylase (ATC) and de novo pyrimidine synthesis resulted in pyrimidine starvation and developmental arrest a few days after germination.
Robert D. Slocum +2 more
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Purine and pyrimidine nucleotide metabolism in Mollicutes [PDF]
Genetics and Molecular Biology, 2007 Several mollicute genome projects are underway, offering unique opportunities to study genes and metabolic pathways on a genome-wide scale. Here, we have analyzed the conservation and diversity of purine and pyrimidine metabolism in mycoplasmas. An evaluation of discrepancies between genomic analysis and enzymatic data revealed interesting aspects ...
Bizarro, Cristiano Valim +1 more
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Nature Communications, 2023 Purine-containing nucleotide second messengers regulate diverse cellular activities. Cyclic di-pyrimidines mediate anti-phage functions in bacteria; however, the synthesis mechanism remains elusive.
Chia-Shin Yang +5 more
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Molecular determinants of inhibition of UCP1-mediated respiratory uncoupling
Nature Communications, 2023 Brown adipose tissue expresses uncoupling protein 1 (UCP1), which dissipates energy as heat, making it a target for treating metabolic disorders. Here, we investigate how purine nucleotides inhibit respiration uncoupling by UCP1.
Antoine Gagelin +7 more
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Biologia Plantarum, 2021 Nucleotides are the basic elements of the genetic material, participate in bio-energetic processes, are cofactors and components of secondary metabolites, etc. Nucleotide hydrolases (nucleotidases) are phosphatases that remove the 5'-phosphate group from
G. GALVEZ-VALDIVIESO +3 more
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