Results 11 to 20 of about 42,575 (244)
The effect of cCMP and cUMP on growth of Pseudomonas aeruginosa [PDF]
Frontiers in MicrobiologyThe aim of this study was to screen for possible biological effects of the non-canonical nucleotides 3’,5’-cyclic uridine monophosphate (cUMP) and 3’,5’-cyclic cytidine monophosphate (cCMP) on Pseudomonas aeruginosa beyond the already reported function ...
Christoph Risser +6 more
doaj +2 more sources
Re-Discovery of Pyrimidine Salvage as Target in Cancer Therapy
Cells, 2022 Nucleotides are synthesized through two distinct pathways: de novo synthesis and nucleoside salvage. Whereas the de novo pathway synthesizes nucleotides from amino acids and glucose, the salvage pathway recovers nucleosides or bases formed during DNA or ...
Melanie Walter, Patrick Herr
doaj +1 more source
De novo nucleotide biosynthetic pathway and cancer
Genes and Diseases, 2023 De novo nucleotide biosynthetic pathway is a highly conserved and essential biochemical pathway in almost all organisms. Both purine nucleotides and pyrimidine nucleotides are necessary for cell metabolism and proliferation.
Jie Chen +7 more
doaj +1 more source
Nature Communications, 2023 Purine-containing nucleotide second messengers regulate diverse cellular activities. Cyclic di-pyrimidines mediate anti-phage functions in bacteria; however, the synthesis mechanism remains elusive.
Chia-Shin Yang +5 more
doaj +1 more source
Molecular determinants of inhibition of UCP1-mediated respiratory uncoupling
Nature Communications, 2023 Brown adipose tissue expresses uncoupling protein 1 (UCP1), which dissipates energy as heat, making it a target for treating metabolic disorders. Here, we investigate how purine nucleotides inhibit respiration uncoupling by UCP1.
Antoine Gagelin +7 more
doaj +1 more source
Biologia Plantarum, 2021 Nucleotides are the basic elements of the genetic material, participate in bio-energetic processes, are cofactors and components of secondary metabolites, etc. Nucleotide hydrolases (nucleotidases) are phosphatases that remove the 5'-phosphate group from
G. GALVEZ-VALDIVIESO +3 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Remdesivir (RDV) has generated much anticipation for its moderate effect in treating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Yan Li +8 more
doaj +1 more source
Enzymatic De Novo Pyrimidine Nucleotide Synthesis [PDF]
Journal of the American Chemical Society, 2010 The use of stable isotope labeling has revolutionized NMR studies of nucleic acids, and there is a need for methods of incorporation of specific isotope labels to facilitate specific NMR experiments and applications. Enzymatic synthesis offers an efficient and flexible means to synthesize nucleoside triphosphates from a variety of commercially ...
Heather L, Schultheisz +3 more
openaire +2 more sources
BMC Genomics, 2005 Background Eukaryotic organisms contain mitochondria, organelles capable of producing large amounts of ATP by oxidative phosphorylation. Each cell contains many mitochondria with many copies of mitochondrial DNA in each organelle.
Samuels David C +2 more
doaj +1 more source
Saliva Metabolomics in Dry Mouth Patients with Head and Neck Cancer or Sjögren’s Syndrome
Cells, 2022 The etiology of dry mouth conditions is multi-faceted. Patients radiated after head and neck cancer (HNC) and those with primary Sjögren’s syndrome (pSS) share many of the same symptoms despite different causes.
Håvard Hynne +6 more
doaj +1 more source