Results 201 to 210 of about 643,096 (374)

Derivatives of MOPS: promising scaffolds for SARS coronaviruses Macro domain‐targeted inhibition

The FEBS Journal, EarlyView.
The SARS‐CoV/CoV‐2 genome encodes non‐structural protein 3, which contains a ‘Macro domain’. This protein domain exhibits antagonistic activity against interferon signaling, which disrupts the host innate immune response and can thus mediate viral escape, highlighting its therapeutic potential.
Oney Ortega Granda, Karine Alvarez, Benjamin Morin, Bruno Canard, François Ferron, Nadia Rabah   +5 more
wiley   +1 more source

A steric gate prevents mutagenic dATP incorporation opposite 8‐oxo‐deoxyguanosine in mitochondrial DNA polymerases

The FEBS Journal, EarlyView.
Reactive oxygen species induce mutagenic DNA lesions, such as 8‐oxo‐2′‐deoxyguanosine (8‐oxodG), which acts as a template for dCMP and dAMP incorporation through its anti and syn conformations. Specific residues must regulate the fidelity of templated 8‐oxodG.
Noe Baruch‐Torres, Carlos H. Trasviña‐Arenas, Alexandru Ionut Gilea, Upeksha C. Dissanayake, Missael Molina‐Jiménez, Paola L. García‐Medel, Corina Díaz‐Quezada, Tiziana Lodi, G. Andrés Cisneros, Enrico Baruffini, Luis G. Brieba   +10 more
wiley   +1 more source

81 ERYTHROCYTE PYRIMIDINE NUCLEOTIDE METABOLISM 5′-NUCLOTIDASE HPLC ASSAY AND OBSERVATIONS ON THE ENZYME BEHAVIOR [PDF]

, 1988
Adolfo Amici, Ferruccio Santini, Giulio Magni   +2 more
openalex   +1 more source

Molecular Analysis of the Interaction of Anthrax Adenylyl Cyclase Toxin, Edema Factor, with 2′(3′)-O-(N-(methyl)anthraniloyl)-Substituted Purine and Pyrimidine Nucleotides

Molecular Pharmacology, 2009
Hesham Taha, Jennifer Schmidt, Martin Göttle, S. Suryanarayana, Yuequan Shen, Wei-Jen Tang, A. Gille, Jens Geduhn, B. König, S. Dove, R. Seifert   +10 more
semanticscholar   +1 more source

Y12C mutation disrupts IMPDH cytoophidia and alters cancer metabolism

The FEBS Journal, EarlyView.
IMPDH, the rate‐limiting enzyme for de novo GTP synthesis, can form polymers and cytoophidia to enhance activity by reducing GTP inhibition. In this study, a Y12C mutation in IMPDH2 was introduced via ABEmax base‐editing in human cancer cell lines to disrupt IMPDH polymerisation.
Chia‐Chun Chang, Min Peng, Gerson Dierley Keppeke, Li‐Kuang Tsai, Ziheng Zhang, Li‐Mei Pai, Li‐Ying Sung, Ji‐Long Liu   +7 more
wiley   +1 more source

Activation of a P2Y4-like purinoceptor triggers an increase in cytosolic [Ca2+] in the red blood cells of the lizard Ameiva ameiva (Squamata, Teiidae)

Brazilian Journal of Medical and Biological Research, 2005
An increasing number of pathophysiological roles for purinoceptors are emerging, some of which have therapeutic potential. Erythrocytes are an important source of purines, which can be released under physiological and physiopathological conditions ...
Sartorello R., Garcia C.R.S.
doaj  

Transcription‐coupled repair: tangled up in convoluted repair

The FEBS Journal, EarlyView.
In this review, we discuss recent findings derived from diverse genomic, biochemical and structural, imaging, and functional studies (B–E) that culminated in deep mechanistic insight (A) into the vital cellular process of transcription‐coupled nucleotide excision repair (TC‐NER).
Diana A. Llerena Schiffmacher, Yun Jin Pai, Alex Pines, Wim Vermeulen   +3 more
wiley   +1 more source

Inhibitory effects of 2-thiouracil and 2-thiouracil metabolites on enzymes involved in pyrimidine nucleotide biosynthesis

, 1974
Robert S. Lindsay, Mei‐ying W. Yu
openalex   +1 more source

A molecular mechanism for pyrimidine and purine nucleotide control of aspartate transcarbamoylase [PDF]

, 1993

openalex   +1 more source

DmdA‐independent lag phase shortening in Phaeobacter inhibens bacteria under stress conditions

The FEBS Journal, EarlyView.
The lag phase is crucial for resuming bacterial growth and can be shortened by fueling the methionine cycle with methyl groups from DMSP or other methylated compounds. While DmdA is the primary DMSP demethylase in Phaeobacter inhibens, stress activates additional enzymes like Bmt. This enzymatic flexibility allows bacteria to exit the lag phase rapidly,
Delia A. Narváez‐Barragán, Martin Sperfeld, Einat Segev   +2 more
wiley   +1 more source