Results 21 to 30 of about 42,575 (244)

Biocoordination reactions in copper(II) ions and phosphocholine systems including pyrimidine nucleosides and nucleotides

Scientific Reports, 2023
The complexation reactions of phosphocholine and pyrimidine nucleosides as well as nucleotides with copper(II) ions were studied in the water system.
Malwina Gabryel-Skrodzka, Martyna Nowak, Jakub Grajewski, Renata Jastrząb   +3 more
doaj   +1 more source

Inhibitors of dihydroorotate dehydrogenase cooperate with molnupiravir and N4-hydroxycytidine to suppress SARS-CoV-2 replication

iScience, 2022
Summary: The nucleoside analog N4-hydroxycytidine (NHC) is the active metabolite of the prodrug molnupiravir, which has been approved for the treatment of COVID-19. SARS-CoV-2 incorporates NHC into its RNA, resulting in defective virus genomes. Likewise,
Kim M. Stegmann, Antje Dickmanns, Natalie Heinen, Claudia Blaurock, Tim Karrasch, Angele Breithaupt, Robert Klopfleisch, Nadja Uhlig, Valentina Eberlein, Leila Issmail, Simon T. Herrmann, Amelie Schreieck, Evelyn Peelen, Hella Kohlhof, Balal Sadeghi, Alexander Riek, John R. Speakman, Uwe Groß, Dirk Görlich, Daniel Vitt, Thorsten Müller, Thomas Grunwald, Stephanie Pfaender, Anne Balkema-Buschmann, Matthias Dobbelstein   +24 more
doaj   +1 more source

Efficacy of neuroprotective treatment including pyrimidine nucleotides in secondary uveitic glaucoma

Journal of Ophthalmology, 2018
Background: Secondary glaucoma is found in 18% to 38% of patients with uveitis, and is one of the most severe uveitic complications. The glaucomatous process is characterized by the progressive optic nerve neuropathy. The lack of efficacy of conventional
V. V. Savko, V. V. Savko Jnr
doaj   +1 more source

Fluorescent Nanoparticles Synthesized from DNA, RNA, and Nucleotides

Nanomaterials, 2021
Ubiquitous on Earth, DNA and other nucleic acids are being increasingly considered as promising biomass resources. Due to their unique chemical structure, which is different from that of more common carbohydrate biomass polymers, materials based on ...
Maofei Wang, Masaki Tsukamoto, Vladimir G. Sergeyev, Anatoly Zinchenko   +3 more
doaj   +1 more source

Palladium-Catalyzed Modification of Unprotected Nucleosides, Nucleotides, and Oligonucleotides

Molecules, 2015
Synthetic modification of nucleoside structures provides access to molecules of interest as pharmaceuticals, biochemical probes, and models to study diseases.
Kevin H. Shaughnessy
doaj   +1 more source

Loss in the Antibacterial Ability of a PyrR Gene Regulating Pyrimidine Biosynthesis after Using CRISPR/Cas9-Mediated Knockout for Metabolic Engineering in Lactobacillus casei

Microorganisms, 2023
Lactobacillus casei (L. casei) has four possible mechanisms: antimicrobial antagonism, competitional adhesion, immunoregulation, and the inhibition of bacterial toxins. To delineate the metabolic reactions of nucleotides from L. casei that are associated
Shaojun Chen, Xinmiao He, Ziliang Qin, Gang Li, Wentao Wang, Zida Nai, Yaguang Tian, Di Liu, Xinpeng Jiang   +8 more
doaj   +1 more source

Inhibition of the de novo pyrimidine biosynthesis pathway limits ribosomal RNA transcription causing nucleolar stress in glioblastoma cells.

PLoS Genetics, 2020
Glioblastoma is the most common and aggressive type of cancer in the brain; its poor prognosis is often marked by reoccurrence due to resistance to the chemotherapeutic agent temozolomide, which is triggered by an increase in the expression of DNA repair
M Carmen Lafita-Navarro, Niranjan Venkateswaran, Jessica A Kilgore, Suman Kanji, Jungsoo Han, Spencer Barnes, Noelle S Williams, Michael Buszczak, Sandeep Burma, Maralice Conacci-Sorrell   +9 more
doaj   +1 more source

Rapid and reliable RNA resonance assignment by combining chemical and enzymatic stable isotope labeling

Journal of Magnetic Resonance Open, 2022
In this work a rapid RNA assignment approach by combining chemical and enzymatic 13C and 15N stable isotope labeling is introduced. We exemplify the assignment strategy for imino N1H1 purine and N3H3 pyrimidine and aromatic C6H6 pyrimidine, C8H8 purine ...
David Klingler, Matthias Huber, Martin Tollinger, Christoph Kreutz   +3 more
doaj   +1 more source

Purine and Pyrimidine Nucleotide Synthesis and Metabolism [PDF]

The Arabidopsis Book, 2002
Purine and pyrimidine nucleotides are major energy carriers, subunits of nucleic acids and precursors for the synthesis of nucleotide cofactors such as NAD and SAM. Despite the obvious importance of these molecules, we still have much to learn about how these nucleotides are synthesized and metabolized by plants. Moreover, of the research that has been
Barbara A, Moffatt, Hiroshi, Ashihara
openaire   +2 more sources

Dihydroorotate dehydrogenase inhibition acts synergistically with tyrosine kinase inhibitors to induce apoptosis of mantle cell lymphoma cells

eJHaem, 2022
Mantle cell lymphoma (MCL) is a non‐Hodgkin lymphoma that remains incurable with the treatment options available today. In the present study, we have identified the dihydroorotate dehydrogenase (DHODH), an essential enzyme for the de novo biosynthesis of
May Eriksen‐Gjerstad, Ida Tveit Karlsen, Zinayida Fandalyuk, Susanne Benjaminsen, Fanny Baran‐Marszak, Bela Papp, Frederick Locke, Marcus Ladds, Andrés Pastor‐Fernández, Pascal Gelebart, Emmet Mc Cormack   +10 more
doaj   +1 more source