Results 31 to 40 of about 643,096 (374)
Microorganisms, 2023 Lactobacillus casei (L. casei) has four possible mechanisms: antimicrobial antagonism, competitional adhesion, immunoregulation, and the inhibition of bacterial toxins. To delineate the metabolic reactions of nucleotides from L. casei that are associated
Shaojun Chen +8 more
doaj +1 more source
Fluorescent Nanoparticles Synthesized from DNA, RNA, and Nucleotides
Nanomaterials, 2021 Ubiquitous on Earth, DNA and other nucleic acids are being increasingly considered as promising biomass resources. Due to their unique chemical structure, which is different from that of more common carbohydrate biomass polymers, materials based on ...
Maofei Wang +3 more
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Nucleotide-, chemotactic peptide- and phorbol ester-induced exocytosis in HL-60 leukemic cells [PDF]
, 1990 Undifferentiated and differentiated HL-60 leukemic cells possess nucleotide receptors which functionally couple to phospholipase C via pertussis toxin-sensitive guanine nucleotide-binding proteins (G-proteins).
Seifert, Roland +1 more
core +1 more source
Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy [PDF]
, 2017 Leishmania pyrimidine salvage is replete with opportunities for therapeutic intervention with enzyme inhibitors or antimetabolites. Their uptake into cells depends upon specific transporters; therefore it is essential to establish whether various ...
Ali, Juma A.M. +7 more
core +2 more sources
eJHaem, 2022 Mantle cell lymphoma (MCL) is a non‐Hodgkin lymphoma that remains incurable with the treatment options available today. In the present study, we have identified the dihydroorotate dehydrogenase (DHODH), an essential enzyme for the de novo biosynthesis of
May Eriksen‐Gjerstad +10 more
doaj +1 more source
Interactions of slow electrons with biomolecules [PDF]
, 2007 We report on results of computational studies of the interaction of slow electrons with the purine and pyrimidine bases of DNA, as well as with their associated nucleosides and nucleotides.
McKoy, Vincent, Winstead, Carl
core +1 more source
Antioxidants, 2022 Glucose and glutamine play a crucial role in the metabolic reprogramming of cancer cells. Proliferating cells metabolize glucose in the aerobic glycolysis for energy supply, and glucose and glutamine represent the primary sources of carbon atoms for the ...
Tiziana Pecchillo Cimmino +5 more
doaj +1 more source
De novo prediction of PTBP1 binding and splicing targets reveals unexpected features of its RNA recognition and function. [PDF]
, 2014 The splicing regulator Polypyrimidine Tract Binding Protein (PTBP1) has four RNA binding domains that each binds a short pyrimidine element, allowing recognition of diverse pyrimidine-rich sequences.
Black, Douglas L +5 more
core +3 more sources
PLoS Genetics, 2020 Glioblastoma is the most common and aggressive type of cancer in the brain; its poor prognosis is often marked by reoccurrence due to resistance to the chemotherapeutic agent temozolomide, which is triggered by an increase in the expression of DNA repair
M Carmen Lafita-Navarro +9 more
doaj +1 more source
Pyrimidine Salvage Enzymes Are Essential for De Novo Biosynthesis of Deoxypyrimidine Nucleotides in Trypanosoma brucei. [PDF]
PLoS Pathogens, 2016 The human pathogenic parasite Trypanosoma brucei possess both de novo and salvage routes for the biosynthesis of pyrimidine nucleotides. Consequently, they do not require salvageable pyrimidines for growth.
Christopher Leija +7 more
doaj +1 more source