Results 41 to 50 of about 643,096 (374)
PLoS Pathogens, 2023 ExoY virulence factors are members of a family of bacterial nucleotidyl cyclases (NCs) that are activated by specific eukaryotic cofactors and overproduce cyclic purine and pyrimidine nucleotides in host cells.
Magda Teixeira Nunes +9 more
doaj +1 more source
Enzymatic De Novo Pyrimidine Nucleotide Synthesis [PDF]
Journal of the American Chemical Society, 2010 The use of stable isotope labeling has revolutionized NMR studies of nucleic acids, and there is a need for methods of incorporation of specific isotope labels to facilitate specific NMR experiments and applications. Enzymatic synthesis offers an efficient and flexible means to synthesize nucleoside triphosphates from a variety of commercially ...
Heather L. Schultheisz +3 more
openaire +3 more sources
Palladium-Catalyzed Modification of Unprotected Nucleosides, Nucleotides, and Oligonucleotides
Molecules, 2015 Synthetic modification of nucleoside structures provides access to molecules of interest as pharmaceuticals, biochemical probes, and models to study diseases.
Kevin H. Shaughnessy
doaj +1 more source
Ectonucleotidases in Acute and Chronic Inflammation
Frontiers in Pharmacology, 2021 Ectonucleotidases are extracellular enzymes with a pivotal role in inflammation that hydrolyse extracellular purine and pyrimidine nucleotides, e.g., ATP, UTP, ADP, UDP, AMP and NAD+. Ectonucleotidases, expressed by virtually all cell types, immune cells
Anna Lisa Giuliani +2 more
doaj +1 more source
Journal of Medicinal Chemistry, 2011 P2Y(2) and P2Y(4) receptors are G protein-coupled receptors, activated by UTP and dinucleoside tetraphosphates, which are difficult to distinguish pharmacologically for lack of potent and selective ligands.
H. Maruoka +8 more
semanticscholar +1 more source
De novo nucleotide biosynthetic pathway and cancer
Genes and Diseases, 2023 De novo nucleotide biosynthetic pathway is a highly conserved and essential biochemical pathway in almost all organisms. Both purine nucleotides and pyrimidine nucleotides are necessary for cell metabolism and proliferation.
Jie Chen +7 more
doaj
Gene dosage effects in yeast support broader roles for the LOG1, HAM1 and DUT1 genes in detoxification of nucleotide analogues. [PDF]
PLoS ONE, 2018 Purine and pyrimidine analogues have important uses in chemotherapies against cancer, and a better understanding of the mechanisms that cause resistance to these drugs is therefore of importance in cancer treatment. In the yeast Saccharomyces cerevisiae,
Mattias Carlsson +2 more
doaj +1 more source
Brain pyrimidine nucleotide synthesis and Alzheimer disease
Aging, 2019 Many patients suffering late-onset Alzheimer disease show a deficit in respiratory complex IV activity. The de novo pyrimidine biosynthesis pathway connects with the mitochondrial respiratory chain upstream from respiratory complex IV. We hypothesized that these patients would have decreased pyrimidine nucleotide levels.
Pesini, Alba +11 more
openaire +6 more sources
Proton-impact-induced electron emission from biologically relevant molecules studied with a screened independent atom model [PDF]
J. Phys. B 52, 195203 (2019), 2019 We use the recently introduced independent-atom-model pixel counting method to calculate proton-impact net ionization cross sections for a large class of biologically relevant systems including pyrimidines, purines, amino acids, and nucleotides from 10 keV to 10 MeV impact energy. Overall good agreement with experimental data, where available, is found.
arxiv +1 more source
Functionalized nanopore-embedded electrodes for rapid DNA sequencing [PDF]
, 2007 The determination of a patient's DNA sequence can, in principle, reveal an increased risk to fall ill with particular diseases [1,2] and help to design "personalized medicine" [3].
Ahuja, Rajeev +7 more
core +1 more source