Results 151 to 160 of about 48,617 (303)

Evaluating 7‑Aminopyrazolo[4,3‑<i>d</i>]pyrimidines as Human A₁ and A₃ Adenosine Receptor Antagonists. [PDF]

ACS Omega
Georgiou K, Lamprakopoulou M, Buthmann H, Böing S, Pousias A, Dexter A, Chew EXY, Huang X, Michalettou EI, Pearce A, Dotsikas Y, Pouli N, Marakos P, Kolocouris A, Ladds G, Lougiakis N.   +15 more
europepmc   +1 more source

New Hydrazone Derivatives Featuring Isatin and Piperazine Moieties: Synthesis, Cytotoxicity Evaluation, and Molecular Modeling Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT In this study, ten novel compounds (IPH1–IPH10) were designed by integrating three pharmacophores (isatin, piperazine, and hydrazone) commonly found in the molecular structures of anticancer agents. The target molecules were obtained by the reaction of in‐house prepared 4‐(4‐(pyridin/pyrimidin‐2‐yl)piperazin‐1‐yl)benzohydrazide with various ...
Semiha Köprü, Münevver Baran, Miyase Gözde Gündüz, Şengül Dilem Doğan   +3 more
wiley   +1 more source

Synthesis, Cytotoxicity, and Apoptosis‐Associated Cell Death Activity of an Isatin‐Containing Pyrimidine‐Derived Cu(II) Complex

Journal of Applied Toxicology, EarlyView.
ABSTRACT A Cu(II) complex derived from a pyrimidine with the isatin group was synthesized and tested for its cytotoxic effects on A549 lung cancer and MCF‐7 breast cancer cell lines, as well as its effects on apoptosis‐associated cell death and cell cycle regulation in A549 cells. To evaluate cytotoxicity, MTT assays were performed at 24, 48, and 72 h,
Müjgan Kesik Oktay, Cansu Topkaya, Elif Kağa, Yasin Eren, Ramazan Güp   +4 more
wiley   +1 more source

Solvent-free and green synthesis of fused pyrimidine derivatives catalyzed by pillar[5]arene-based Lewis acid ionic liquid. [PDF]

Sci Rep
Rastegar S, Mohammadpoor-Baltork I, Asghari S, Tangestaninejad S, Moghadam M, Notash B.   +5 more
europepmc   +1 more source

Alpha‐Synuclein Promotes Anterograde Vesicle Transport in Melanocytes and Melanoma Cells: A Pro‐Survival Function

Journal of the Chinese Chemical Society, EarlyView.
Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley   +1 more source

Recent green approaches for the synthesis of thienopyrimidine scaffolds: an overview (2007-2025). [PDF]

RSC Adv
Rabeh RM, Kassab AE, Hassan RA, Shahin IG.   +3 more
europepmc   +1 more source

Biochemical testing and pathology reveal rare cause of pediatric acute liver failure: Hyperornithinemia‐hyperammonemia‐homocitrullinuria syndrome

JPGN Reports, EarlyView.
Abstract Hyperornithinemia‐hyperammonemia‐homocitrullinuria (HHH) syndrome is a rare metabolic condition that can cause lethargy, ataxia, tachypnea, nausea, vomiting, seizures, coma, and acute liver failure. We present a 26‐month‐old female with acute liver failure who was diagnosed with HHH 1 week after admission. Histology revealed an acute hepatitic
Tierra L. Mosher, Kathryn S. Czepiel, Matthew B. Neu, Andrea Carolina Cortes Fernandez, L. Walden Browne, Annie D. Niehaus, Roberto Gugig   +6 more
wiley   +1 more source

The antitumor promise of furo[2,3-<i>d</i>]pyrimidine: a 2016-2025 review. [PDF]

RSC Adv
Mansour MA, Elshafei HA, Sayed AS, Ashour AA, Hussein NE, Abdel Karim MM, Kamel FM, Elsayed NT, Ahmed MR, Seleem MT, Gomaa RM.   +10 more
europepmc   +1 more source

Chemical Kinetics of 2‐, 4‐, and 2,4‐Seleno‐Uracils at Low Temperatures: Tautomerizations and Rotamerizations on Inert Matrices

International Journal of Chemical Kinetics, EarlyView.
ABSTRACT In the interstellar medium, chemical reactions proceed under conditions vastly different to those on Earth; these include extremely low temperatures and densities and take place in the gas phase and on water–ice grains. Understanding the energetics and more importantly the kinetics of such reactions is of relevance to the consequences on how ...
Judith Wurmel, John M. Simmie
wiley   +1 more source

A facile threecomponent solid phase synthesis of steroidal Aring fused pyrimidines under microwave irradiation [PDF]

The preparation of ringA fused pyrimidines at the steroidal 2,3position is herein described. The novel steroidal pyrimidines were prepared from the solid phase threecomponent reaction of 2hydroxymethylene3keto steroids, arylaldehydes and ammonium ...
Gogoi, Shyamalee, Borthakur, M G, Boruah, R C, Dutta, Mandakini   +3 more
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