Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future
Medicinal Research Reviews, EarlyView.ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley +1 more source
The utility of pyrimidine derivatives in the construction of azolo[<i>d</i>]pyrimidine: part II-multi-nitrogen azole systems with potential biological applications. [PDF]
RSC AdvShamroukh AH, Rashad AE.
europepmc +1 more source
Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms
Medicinal Research Reviews, EarlyView.ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino +3 more
wiley +1 more source
PCSK9 Inhibitors Reduce Oxidative Stress Biomarkers in Heterozygous Familial Hypercholesterolemia. [PDF]
J Cell Mol MedWoźniak-Szczepocka A +5 more
europepmc +1 more source
PHOTOELECTRON STUDIES AND ELECTRONIC INFLUENCES OF BIOLOGICAL PURINES AND PYRIMIDINES.
, 1980 PHOTOELECTRON STUDIES AND ELECTRONIC INFLUENCES OF BIOLOGICAL PURINES AND ...
JUNG-HUI. LIN (7979771)
core
AI/ML Enabled High‐Throughput Design and Synthesis for Energetic Molecules
Materials Genome Engineering Advances, EarlyView.Novel design methods for a special kind of functional molecules — the energetic molecules—are summarized. Both classic Machine Learning (ML) and Artificial Intelligence (AI) generative models are utilized for the high‐throughput design of these energetic molecules, and a sort of high‐energy low‐sensitivity molecules are obtained.
Wen Qian
wiley +1 more source
Rational synthesis of pyrazolopyrimidines <i>via</i> cyclocondensation of ynones obtained from the Sonogashira reaction. [PDF]
RSC AdvBhagat S, Goel N, Kumari P, Kumar P.
europepmc +1 more source
Rapid and quantitative phage susceptibility test by ramanome
mLife, EarlyView.Abstract Antimicrobial resistance poses an escalating global threat, renewing interest in bacteriophage therapy as a precision alternative to antibiotics. However, clinical translation remains hindered by the lack of rapid and quantitative phage susceptibility testing (PST) platforms capable of evaluating host range, infection potency, and effective ...
Xiao Han +10 more
wiley +1 more source
A Novel Multimodal LC-MS/MS Panel for the Comprehensive Diagnosis of Neurometabolic Disorders in CSF. [PDF]
J Inherit Metab DisChrist S +8 more
europepmc +1 more source