Results 161 to 170 of about 48,617 (303)

Design, synthesis and biological evaluation of 2,5-diaryloxazolo[4,5-<i>d</i>]pyrimidin-7-ylamines as selective cytotoxic agents against HeLa cells. [PDF]

Beilstein J Org Chem
Kachaeva MV, Kachaeva MV, Olejniczak AB, Denel-Bobrowska M, Zhirnov VV, Velihina YS, Pilyo SG, Brovarets VS.   +7 more
europepmc   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Synthesis of new pyrazolo[3,4-d]pyrimidines as potential mutant EGFR/HER2 and Bcl2 inhibitors: anticancer evaluation, DFT, molecular docking and ADME studies. [PDF]

BMC Chem
Metwally NH, Saad ZA, Mohamed MS.
europepmc   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Influence of Phosphate Activation Chemistry on the Selection of the Primordial Genetic Alphabet. [PDF]

J Am Chem Soc
Bošković F, Zhang J, Swatiputra AA, Szostak JW.   +3 more
europepmc   +1 more source

Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms

Medicinal Research Reviews, EarlyView.
ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino, Manuela Bartolini, Rudolf Andrys, Kamil Musilek   +3 more
wiley   +1 more source

Metal-free Minisci C-H alkylation of hydrazones using aldehydes: an unexpected route to hydrazone-containing pyrimidine derivatives. [PDF]

RSC Adv
Tirehdast A, Semeniuchenko V, Shiri A.
europepmc   +1 more source

AI/ML Enabled High‐Throughput Design and Synthesis for Energetic Molecules

Materials Genome Engineering Advances, EarlyView.
Novel design methods for a special kind of functional molecules — the energetic molecules—are summarized. Both classic Machine Learning (ML) and Artificial Intelligence (AI) generative models are utilized for the high‐throughput design of these energetic molecules, and a sort of high‐energy low‐sensitivity molecules are obtained.
Wen Qian
wiley   +1 more source

Regioselective synthesis, structural investigation and binding behavior of 6-aroyl-7-aryl-5-methyl-4,7-dihydro-[1,2,4]triazolo[1,5-<i>a</i>]pyrimidines with BSA using various spectroscopic and <i>in silico</i> methods. [PDF]

RSC Adv
Aggarwal R, Sharma M, Sumran G, Kumar S, Kumar P.   +4 more
europepmc   +1 more source

Abundance of atrazine degrading genes trzN versus atzA in soil cultures and in situ degradation rates

Pest Management Science, EarlyView.
Atrazine degradation in agricultural soils showed in situ half‐lives of 36–225 days. Field and laboratory results indicate active microbial hydrolysis driven mainly by trzN. Biphasic degradation sustains long‐term persistence, maintaining the potential for groundwater contamination despite reduced immediate leaching risk.
Truphena Akinyi, Damiana Diaz‐Reck, Aman Raj, Anat Bernstein   +3 more
wiley   +1 more source