Results 181 to 190 of about 73,935 (281)

Skeletal editing of 4-arylpyrimidines into diverse nitrogen heteroaromatics via four-atom synthons. [PDF]

Nat Commun
Li S, Shi Y, Tang J, Yan M, Huang S, Dou T, Wang S, Jin X, Su Z, Jiang W, Xu J, Zheng X, Li R, Chen H, Xue W, Fu H.   +15 more
europepmc   +1 more source

Therapeutic effect of NEO400, perillyl alcohol conjugated to linoleic acid, in a mouse model of UV‐induced skin damage

Photochemistry and Photobiology, Volume 101, Issue 2, Page 338-349, March/April 2025.
In the present work with mouse models, we demonstrate that a novel compound, NEO400, is able to profoundly protect skin against damage caused by UV radiation (UVR) when it is applied to skin post‐UVR exposure. In comparison, Aloe vera or linoleic acid are unable to achieve a similar level of protection.
Stephen Swenson, Catalina Silva‐Hirschberg, Liliana Freeland, Kristen L. Chen, Nagore I. Marín‐Ramos, Axel H. Schönthal, Thomas C. Chen   +6 more
wiley   +1 more source

Distribution of extraterrestrial nucleobases, other N-heterocycles, and their precursors in a sample from asteroid Bennu. [PDF]

Commun Chem
Oba Y, Koga T, Takano Y, Naraoka H, Hirakawa Y, Sunami S, Furukawa Y, Yamazaki T, Tomaru T, Dworkin JP, Glavin DP, Connolly HC, Lauretta DS.   +12 more
europepmc   +1 more source

Interventional human ocular safety experiments for 222‐nm far‐ultraviolet‐C lamp irradiation

Photochemistry and Photobiology, Volume 101, Issue 2, Page 517-526, March/April 2025.
To directly assess the ocular safety of 222‐nm far‐ultraviolet‐C (UVC) irradiation in humans, five subjects were exposed to 222‐nm UVC at doses of 22, 50, and 75 mJ/cm2. The findings indicate that far‐UVC irradiation does not cause “clinically significant photokeratitis” or long‐term ocular damage, though it may induce temporary discomfort.
Kazunobu Sugihara, Sachiko Kaidzu, Masahiro Sasaki, Masaki Tanito   +3 more
wiley   +1 more source

A Review of Recent Progress on the Anticancer Activity of Heterocyclic Compounds

SynOpen
Beena Negi, Aarshiya Kwatra
doaj   +1 more source

Preparation and characterization of kaolin-[TMS]-NH₂ ⁺C(NO₂)₃ ^- as a novel heterogeneous nano-catalyst and its use in the synthesis of imidazo[1,2-<i>a</i>]pyrimidine and 1,2,4-triazolo[4,3-<i>a</i>]pyrimidines. [PDF]

RSC Adv
Dorostkar M, Nazemi-Nasyrmahale L, Shirini F.   +2 more
europepmc   +1 more source

PLK4 is a potential therapeutic target in nonmelanoma skin cancers: Evidence from molecular and in vivo studies

Photochemistry and Photobiology, EarlyView.
Exposure to solar ultraviolet radiation is the main etiologic driver of nonmelanoma skin cancers (NMSCs), including basal cell (BCC) and cutaneous squamous cell carcinomas (cSCC), which are the most prevalent types of cancers in the US. In this study, we demonstrate that the serine/threonine kinase Polo‐like kinase 4 (PLK4) is overexpressed in NMSCs ...
Mary A. Ndiaye, Debra R. Garvey, Gagan Chhabra, Chandra K. Singh, Minakshi Nihal, Nihal Ahmad   +5 more
wiley   +1 more source

<i>p</i>TSA-catalyzed synthesis of functionalized chromeno[2,3-<i>d</i>]pyrimidine/chromeno[4,3-<i>b</i>]chromene derivatives <i>via</i> one-pot three component reaction: mechanistic insights and variable temperature NMR studies to investigate restricted bond rotation. [PDF]

RSC Adv
Singh Tanwer YB, Sourabh S, Bhunia S, Pal S, Das D.   +4 more
europepmc   +1 more source

Alloxazine derivatives as multifunctional agents for photodynamic therapy, cancer cell imaging, and cell proliferation inhibition

Photochemistry and Photobiology, EarlyView.
Alloxazine photosensitizers, molecularly engineered through sugar conjugation and methoxy substitution to enhance solubility, photodynamic potency, and fluorescence, enable image‐guided photodynamic therapy while inhibiting cancer cell growth in the absence of photoactivation.
Rubej R. Khan, Sourav Kanti Seth, Reshma Mathew, Nitza V. Falcón‐Cruz, Chris Acquah, Steffen Jockusch, Liraz Levi, Carlos E. Crespo‐Hernández   +7 more
wiley   +1 more source

5-Amino- and 6-amino-uracils in the synthesis of various heterocycles as therapeutic agents: a review. [PDF]

RSC Adv
Aly AA, Osman EM, Mostafa SM, Bedair TM, Abd-Elmonem M, Sadek KU, Mohamed AH.   +6 more
europepmc   +1 more source