Results 81 to 90 of about 3,409 (207)

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, Volume 13, Issue 61, 3 November 2026.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

A Surprising Role for Vacuolar Pyrophosphatase [PDF]

The Plant Cell, 2011
Following germination, seed plants rely on stored nutrient reserves to sustain growth of the embryo. In oil-containing seeds, this period of heterotrophic growth requires β-oxidation, the glyoxylate cycle, and gluconeogenesis to convert stored lipids to sucrose, which provides energy to ...
openaire   +2 more sources

Matrix Vesicle‐Associated SMS2 as a Novel Mediator of Biomineralization

Journal of Extracellular Biology, Volume 5, Issue 11, November 2026.
ABSTRACT SGMS2, a gene encoding plasma membrane‐resident sphingomyelin synthase 2, SMS2, has emerged as an important determinant of skeletal ossification. Heterozygous SGMS2 variants are associated with a broad spectrum of bone phenotypes, ranging from rickets‐like deformities in childhood to early‐onset osteoporosis, implicating SMS2 in mineralization
Phillip T. Newton, Mathieu Y. Brunet, Jose G. Marchan‐Alvarez, Outi Mäkitie, Joost C. M. Holthuis   +4 more
wiley   +1 more source

Design Principles of Plant Thermotolerance: Integrating Photosynthesis, Reproduction, and Field Resilience in a Warming Climate

Plant, Cell &Environment, Volume 49, Issue 11, Page 8735-8750, November 2026.
ABSTRACT Global food security is increasingly threatened by climate change, as rising temperatures compromise the yields of major staple crops, including wheat, rice, and maize. Enhancing plant thermotolerance has therefore become a critical priority for sustaining agricultural productivity.
Yuchen Qu, Wataru Yamori
wiley   +1 more source

Naturally occurring quercetin and myricetin as potent inhibitors for human ectonucleotide pyrophosphatase/phosphodiesterase 1

Scientific Reports
Ecto-nucleotide pyrophosphatases/phosphodiesterases 1 (ENPP1) is a key enzyme in purinergic signaling pathways responsible for cell-to-cell communications and regulation of several fundamental pathophysiological processes.
Peeradon Duangiad, Bodee Nutho, Thawatchai Chaijarasphong, Noppawan Phumala Morales, Thunyarat Pongtharangkul, Itaru Hamachi, Akio Ojida, Jirarut Wongkongkatep   +7 more
doaj   +1 more source

De novo Sequencing and Analysis of Lemongrass Transcriptome Provides First Insights into the Essential Oil Biosynthesis of Aromatic Grasses

Frontiers in Plant Science, 2016
Aromatic grasses of the genus Cymbopogon (Poaceae family) represent unique group of plants that produce diverse composition of monoterpene rich essential oils, which have great value in flavour, fragrance, cosmetic and aromatherapy industries.
Seema Meena, Sarma Rajeevkumar, DK Venkata Rao, Varun Dwivedi, HB Shilpashree, Shubhra Rastogi, Ajit Kumar Shasany, Dinesh A Nagegowda   +7 more
doaj   +1 more source

Hidden diversity and potential ecological function of phosphorus acquisition genes in widespread terrestrial bacteriophages

Nature Communications
Phosphorus (P) limitation of ecosystem processes is widespread in terrestrial habitats. While a few auxiliary metabolic genes (AMGs) in bacteriophages from aquatic habitats are reported to have the potential to enhance P-acquisition ability of their ...
Jie-Liang Liang, Shi-wei Feng, Jing-li Lu, Xiao-nan Wang, Feng-lin Li, Yu-qian Guo, Shen-yan Liu, Yuan-yue Zhuang, Sheng-ji Zhong, Jin Zheng, Ping Wen, Xinzhu Yi, Pu Jia, Bin Liao, Wen-sheng Shu, Jin-tian Li   +15 more
doaj   +1 more source

Engineering Inorganic Pyrophosphate Metabolism as a Strategy to Generate a Fluoride-Resistant Saccharomyces cerevisiae Strain

Microorganisms
Fluorine accounts for 0.3 g/kg of the Earth’s crust, being widely distributed in the environment as fluoride. The toxic effects of this anion in humans and other organisms have been known for a long time.
José R. Perez-Castiñeira, Francisco J. Ávila-Oliva, Aurelio Serrano   +2 more
doaj   +1 more source

A Case Series of Sudden Death in Children Aged 12 Months to 4 Years From LPIN1 Deficiency and PPA2 Deficiency in Queensland

Journal of Paediatrics and Child Health, EarlyView.
Sophie Manoy, Sally Smith, Marita Smith, Catherine Atthow, Janette Spicer, Matthew Lynch, Michelle Lipke, Julie A. McEniery, David Coman, Anita Inwood, Jim McGill, Carolyn Bursle   +11 more
wiley   +1 more source

Differential expression of soluble pyrophosphatase isoforms in Arabidopsis upon external stimuli [PDF]

, 2015
In plants, pyrophosphate (PPi), generated in a wide range of reversible anabolic reactions, is hydrolyzed by pyrophosphatases. The presence of tonoplast-and Golgi-integral H+-translocating pyrophosphatases in plants led to the conclusion that plant ...
Greiner, Steffen, Oeztuerk, Zahide Neslihan, Rausch, Thomas, ÖZTÜRK, ZAHİDE NESLİHAN   +3 more
core   +1 more source