Results 71 to 80 of about 51,454 (296)

Practical Synthesis of Ethyl 3‑Fluoro-1-pyrrole-2-carboxylate: A Key Fragment of a Potent Drug Candidate against Hepatitis B Virus

, 2019
We report herein the development of two efficient synthetic routes for the preparation of a key fragment required for the synthesis of potent drug candidates of Hepatitis B virus. The ethyl 3-fluoro-1-H-pyrrole-2-carboxylate scaffold was synthesized from
Yang Cheng (125394), Thomas Poisson (1627144), Jérôme Fortin (7475057), Philippe Jubault, Xavier Pannecoucke, Yicheng Deng (7475054), Philippe Jubault (1627159), Adeline René, Yang Cheng, Jean-François Bonfanti (1670353), Maxime Quilan, Christopher A. Teleha, Pierre Raboisson (1833790), Thomas Poisson, Maxime Quilan (7475051), Jean-François Bonfanti, André. B. Charette, Jérôme Fortin, Pierre Raboisson, Adeline René (1514590), Christopher A. Teleha (1479703), Xavier Pannecoucke (1393786), André. B. Charette (7475060), Yicheng Deng   +23 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

PREPARATION AND CHARACTERIZATION OF CONDUCTIVE PAPER VIA IN-SITU POLYMERIZATION OF PYRROLE

BioResources, 2010
Electrically conductive paper was prepared via in-situ chemical oxidative polymerization of pyrrole by using ferric chloride as an oxidant and p-toluenesulfonic acid (PTSA) as a dopant.
Chunyue Ding, Xueren Qian, Jing Shen, Xianhui An   +3 more
doaj  

Self‐Amplifying Redox Cycle Triggers Ferroptosis/Cuproptosis Synergy for Enhanced Bacterial Eradication

Advanced Science, EarlyView.
This study designs a targeted nanocomposite (ct@HMCF‐Dex) that responds to acidic infection microenvironments, releasing components which amplify oxidative stress. It disrupts bacterial redox balance, chelates metals to sustain lipid peroxidation, and synergistically induces cuproptosis/ferroptosis‐like death.
Zehui Xiao, Shaolong Qiu, Jiangli Cao, Jifeng Liu, Zhiyong Song, Ting Du, Xinjun Du   +6 more
wiley   +1 more source

Marine Streptomyces-Derived Novel Alkaloids Discovered in the Past Decade

Marine Drugs
Natural alkaloids originating from actinomycetes and synthetic derivatives have always been among the important suppliers of small-molecule drugs. Among their biological sources, Streptomyces is the highest and most extensively researched genus.
Zijun Liu, Wenyan Sun, Zhe Hu, Wei Wang, Huawei Zhang   +4 more
doaj   +1 more source

Nanocurvature‐Activated Dipolar Polarization in M–N4 Single‐Atom Sites for High‐Performance Electromagnetic Wave Absorption

Advanced Science, EarlyView.
Increasing nanocurvature effectively enriches the local electron density of the M–N4 motif, which facilitates electron transfer from the metal center to nitrogen atoms. This electronic behavior intensifies the localization and asymmetric distribution of charge, thereby significantly amplifying the dipole moment and polarizability.
Daohu Sheng, Siyao Cheng, Mengmeng Zhang, Jinglei Zhang, Xufei Zhu, Weijin Li, Bo Zhang, Aming Xie   +7 more
wiley   +1 more source

Synthesis, Cytotoxicity and Antiproliferative Effect of New Pyrrole Hydrazones

Molecules
Novel pyrrole-based carbohydrazide (1) and hydrazones (1A–D) were synthesized, characterized, and subjected to spectroscopic studies. The hydrazones were obtained by reacting a pyrrole hydrazide with substituted pyrrole aldehydes.
Stanislava Vladimirova, Rossitsa Hristova, Ivan Iliev   +2 more
doaj   +1 more source

Quantum Dots for Biomedical Biosensing, NIR‐II Bioimaging, and Phototherapy: Materials Design, Signal Transduction, and Translational Barriers

Advanced Science, EarlyView.
This review outlines bottom‐up and biomimetic fabrication strategies of quantum dots, and highlights their emerging applications in biosensing, multimodal bioimaging, and intelligent cancer theranostics. It further discusses key translational barriers and future perspectives for advancing QD‐based nanomedicine toward clinical implementation.
Jie Ju, Zhifang Liu, Xinran Gao, Wen Sun, Wei Fu, Yanfei Wang   +5 more
wiley   +1 more source

Rediscovering Sodium Ionophores as Selective Agents for Lithium Recognition and Extraction

Angewandte Chemie, EarlyView.
Long‐classified sodium ionophores unexpectedly prefer lithium and act as efficient extractants in solid–liquid extraction (SLE). Readily prepared from catechol and haloacetamides, these hosts recover hydrated LiCl from multicomponent salt mixtures via a hydration‐assisted O···Li+ binding mode, enabling scalable lithium separation with Li/Na, Li/K, and ...
Jakub Narodowiec, Aleksandra Kazimierczak, Małgorzata Grela, Magdalena Ceborska, Magdalena Matczuk, Maja Morawiak, Kajetan Dąbrowa   +6 more
wiley   +2 more sources

Microwave-Assisted Synthesis of 1-(5-Substituted-4-hydroxy-2-methyl-1H-pyrrol-3-yl)ethan-1-ones from 2-Amino Acid-Derived Enamine-Type Schiff Bases

Molbank
Pyrrole-type compounds are widely known for their potential biological activity. However, methods for synthesizing 2,3,4,5-tetrasubstituted pyrroles remain limited.
Diego Quiroga, Sergio Torres-Cortés, Ericsson Coy-Barrera   +2 more
doaj   +1 more source