Results 41 to 50 of about 4,020 (99)

The Formation of Pyrroline and Tetrahydropyridine Rings in Amino Acids Catalyzed by Pyrrolysine Synthase (PylD)

, 2014
The dehydrogenase PylD catalyzes the ultimate step of the pyrrolysine pathway by converting the isopeptide L-lysine-Nε-3R-methyl-D-ornithine to the 22nd proteinogenic amino acid.
Beck, Philipp, Quitterer, Felix, Bacher, Adelbert, Groll, Michael   +3 more
core   +1 more source

A readily synthesized cyclic pyrrolysine analogue for site-specific protein "click" labeling

, 2011
A concise route was developed for the facile synthesis of a cyclic pyrrolysine analogue bearing an azide handle. Directed evolution enabled the encoding of this non-natural amino acid in both prokaryotic and eukaryotic cells, which offers a highly ...
Yanqun Song, Jing Wang, Wang, Jing, Shixian Lin, Liang, Yujie, Song, Yanqun, Lin, Shixian, Yujie Liang, Yang, Maiyun, Ziyang Hao, Hao, Ziyang, Peng R. Chen, Maiyun Yang, Chen, Peng R.   +13 more
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Class I and class II lysyl-tRNA synthetase mutants and the genetic encoding of pyrrolysine in Methanosarcina spp.

, 2007
Methanosarcina spp. begin methanogenesis from methylamines with methyltransferases made via the translation of UAG as pyrrolysine. In vitro evidence indicates two possible routes to pyrrolysyl-tRNA(Pyl).
Srinivasan, Gayathri, Meyer, Andrew, Richter, Kerstin B., Chan, Michael, Krzycki, Joseph A., Kang, Patrick T., Lienard, Tanja, Mahapatra, Anirban, Zhao, Gang, Zhang, J., Gottschalk, Gerhard, Metcalf, William W.   +11 more
core   +1 more source

Pyrrolysine and Selenocysteine Use Dissimilar Decoding Strategies [PDF]

, 2005
Selenocysteine (Sec) and pyrrolysine (Pyl) are known as the 21st and 22nd amino acids in protein. Both are encoded by codons that normally function as stop signals.
Vadim N. Gladyshev, Pavel V. Baranov, John F. Atkins, Baranov, Pavel V., Atkins, John F., Yan Zhang, Zhang, Yan, Gladyshev, Vadim N.   +7 more
core  

Low Energy Conformations and Gas-Phase Acidity and Basicity of Pyrrolysine

, 2016
The gas-phase conformational potential energy surfaces (PES) of the last, 22nd amino acid pyrrolysine and related derivatives (neutral, deprotonated, and protonated) were extensively searched for the first time.
Minjie Zhou (1666078), Weidong Wu (296006), Lingbiao Meng (1757560), Jicheng Zhang (1411843), Zhuo Wang (18668)   +4 more
core   +1 more source

Activation of the Pyrrolysine Suppressor tRNA Requires Formation of a Ternary Complex with Class I and Class II Lysyl-tRNA Synthetases [PDF]

, 2003
Monomethylamine methyltransferase of the archaeon Methanosarcina barkeri contains a rare amino acid, pyrrolysine, encoded by the termination codon UAG.
Ruan, Benfang, Tumbula-Hansen, Debra, Ataide, Sandro F., Yokoyama, Shigeyuki, Nureki, Osamu, Ambrogelly, Alexandre, Polycarpo, Carla, Söll, Dieter, Ishitani, Ryuichiro, Ibba, Michael   +9 more
core   +1 more source

An archaeal genetic code with all TAG codons as pyrrolysine

International audienceNumerous genetic codes developed during the evolution of Eukaryotes and three are known in Bacteria, yet no alternative genetic code has been established for Archaea.
Hamlish, Noah, Roe, Leah, Banfield, Jillian, Kivenson, Veronika, Peters, Samantha, Kivenson, Aleksandr, Schepartz, Alanna, Fadhlaoui, Khaled, Borrel, Guillaume, Gribaldo, Simonetta, Hettich, Robert   +10 more
core   +1 more source

Structure and Reaction Mechanism of Pyrrolysine Synthase (PylD)

, 2013
The final step in the biosynthesis of the 22nd genetically encoded amino acid, pyrrolysine, is catalyzed by PylD, a structurally and mechanistically unique dehydrogenase.
Beck, Philipp, Quitterer, Felix, Bacher, Adelbert, Groll, Michael   +3 more
core   +1 more source

Engineering Pyrrolysine Systems for Genetic Code Expansion and Reprogramming. [PDF]

Over the past 16 years, genetic code expansion and reprogramming in living organisms has been transformed by advances that leverage the unique properties of pyrrolysyl-tRNA synthetase (PylRS)/tRNAPyl pairs.

core   +3 more sources

Theoretical Spectroscopic Studies on Chemical and Electronic Structures of Selenocysteine and Pyrrolysine

, 2020
The chemical and electronic structures of the 21st and 22nd proteinogenic amino acid selenocysteine (Sec), pyrrolysine (Pyl), and their derivatives (deprotonated and protonated ions) were extensively characterized for the first time. Through the fragment
Jun Jiang, Yi Luo, Axue Liu, Zhiqiang Wang (48987), Weijie Hua (1864894), Hongbao Li, Yi Luo (143206), Axue Liu (8533344), Jun Jiang (149215), Hongbao Li (8533341), Weijie Hua, Zhiqiang Wang   +11 more
core   +1 more source