Results 241 to 250 of about 142,625 (300)

Biotin deficiency in the rat as a model for reduced pyruvate carboxylase activity

, 1978
J. Schrijver
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PYRUVATE CARBOXYLASE. II. PROPERTIES.

The Journal of biological chemistry, 1996
D B, KEECH, M F, UTTER
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Pyruvate carboxylase

Enzyme Active Sites and their Reaction Mechanisms, 2021
H. Morrison
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“Pyruvate Carboxylase, Structure and Function”

Sub-cellular biochemistry, 2017
Pyruvate carboxylase is a metabolic enzyme that fuels the tricarboxylic acid cycle with one of its intermediates and also participates in the first step of gluconeogenesis. This large enzyme is multifunctional, and each subunit contains two active sites that catalyze two consecutive reactions that lead to the carboxylation of pyruvate into oxaloacetate,
M. Valle
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Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming.

Journal of Medicinal Chemistry, 2021
Cancer cell proliferation in some organs often depends on conversion of pyruvate to oxaloacetate via pyruvate carboxylase (PC) for replenishing the tricarboxylic acid cycle to support biomass production.
Yuwen Sheng, Yuwen Chen, Zhongqiu Zeng, Wenbi Wu, Jing Wang, Yuling Ma, Yuan Lin, Jichao Zhang, Yulan Huang, Wenhua Li, Qiyu Zhu, Xiao-ling Wei, Suiyan Li, Wisanee Wisanwattana, Fu Li, Wanli Liu, A. Suksamrarn, Guolin Zhang, W. Jiao, Fei Wang   +19 more
semanticscholar   +1 more source

Pyruvate carboxylase

The International Journal of Biochemistry & Cell Biology, 1998
Pyruvate carboxylase [EC 6.4.1.1] is a member of the family of biotin-dependent carboxylases and is found widely among eukaryotic tissues and in many prokaryotic species. It catalyses the ATP-dependent carboxylation of pyruvate to form oxaloacetate which may be utilised in the synthesis of glucose, fat, some amino acids or their derivatives and several
Wallace, J., Jitrapakdee, S., Chapman-Smith, A.   +2 more
openaire   +3 more sources

Pyruvate carboxylase deficiency

Journal of Inherited Metabolic Disease, 1984
AbstractThe causes of congenital lactic acidaemia are outlined. Isolated pyruvate carboxylase deficiency is reviewed in detail with a report of a recent case and a discussion of the biochemical consequences. Other causes of defective pyruvate carboxylation are described, particularly the combined carboxylase defects.
K, Bartlett, H K, Ghneim, J H, Stirk, G, Dale, K G, Alberti   +4 more
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Pyruvate Carboxylase Variants Enabling Improved Lysine Production from Glucose Identified by Biosensor-Based High-Throughput Fluorescence-Activated Cell Sorting Screening.

ACS Synthetic Biology, 2019
Pyruvate carboxylase is an anaplerotic carbon dioxide-fixing enzyme replenishing the tricarboxylic acid cycle with oxaloacetate during growth on sugars.
Maike Kortmann, C. Mack, M. Baumgart, M. Bott   +3 more
semanticscholar   +1 more source