Results 151 to 160 of about 145,153 (320)

Functional and evolutionary characterization of potential auxiliary metabolic genes of the global RNA virome

iMetaOmics, Volume 2, Issue 2, June 2025.
We generated the first comprehensive view of RNA viral auxiliary metabolic genes (AMGs), expanding the known functional type of AMGs by 75%. RNA viruses encode a remarkably high diversity of AMGs, spanning 25 distinct functional categories. Most of these genes are linked to environmental regulation and genetic information processing, with fewer ...
Yang Zhao, Zhihao Zhang, Meiling Feng, Rong Wen, Pengfei Liu   +4 more
wiley   +1 more source

Oxidative Stress in Antigen Processing and Presentation

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Reactive oxygen species (ROS) play a crucial role in antigen processing and presentation, essential for linking innate and adaptive immunity. While balanced ROS levels promote immune function, excess ROS can disrupt antigen recognition, resulting in immune dysfunction.
Qinxia Chang, Yaying Zhang, Xiaojun Liu, Peng Miao, Wenbing Pu, Shanshan Liu, Jing Zhang, Yuan Tian, Guobo Shen, Na Xie   +9 more
wiley   +1 more source

Enzymes In Motion Substrate Activation Of Pyruvate Decarboxylases

, 2007
Hasylab Ann. Rep. 2007, 367-368 This report illustrates global structural changes of yeast pyruvate decarboxylases after the addition of substrates and substrate surrogates. We used a SAXS based assay for our experiments.
Kutter, Steffen, Round, Adam, Golbik, Ralph, König, Stephan   +3 more
openaire   +2 more sources

Structural Insights into the Prereaction State of Pyruvate Decarboxylase from Zymomonas mobilis†,‡

Biochemistry, 2010
Pyruvate decarboxylase (PDC) uses thiamine diphosphate as an essential cofactor to catalyze the formation of acetaldehyde on the pathway of ethanol synthesis. Here we report the crystallographic image of a prereaction intermediate of a bacterial pyruvate
X. Pei, K. Erixon, B. Luisi, F. Leeper
semanticscholar   +1 more source

Senegenin regulates the mechanism of insomnia through the Keap1/Nrf2/PINK1/Parkin pathway mediated by GAD67

Journal of Sleep Research, Volume 34, Issue 3, June 2025.
Summary GAD67 impacts insomnia as a key enzyme catalysing the conversion of glutamate (Glu) to gamma‐aminobutyric acid (GABA). Senegenin enhances neuroprotection and is used widely to treat insomnia and other neurological diseases. This study aimed to investigate how senegenin regulates insomnia through a GAD67‐mediated signalling pathway.
Honglin Jia, Xu Chen, Zhengting Liang, Ruining Liang, Jinhong Wu, Yanling Hu, Wenjun Cui, Xingping Zhang   +7 more
wiley   +1 more source

Double duty for a conserved glutamate in pyruvate decarboxylase: evidence of the participation in stereoelectronically controlled decarboxylation and in protonation of the nascent carbanion/enamine intermediate .

Biochemistry, 2010
Pyruvate decarboxylase (PDC) catalyzes the nonoxidative decarboxylation of pyruvate into acetaldehyde and carbon dioxide and requires thiamin diphosphate (ThDP) and a divalent cation as cofactors.
Danilo Meyer, P. Neumann, C. Parthier, R. Friedemann, N. Nemeria, F. Jordan, K. Tittmann   +6 more
semanticscholar   +1 more source

ChnagG Plays the Role of 5‐Salicylate Hydroxylase in the Gentisic Acid Pathway of Salicylic Acid Metabolism in Cochliobolus heterostrophus

Molecular Plant Pathology, Volume 26, Issue 6, June 2025.
The ChnagG gene in Cochliobolus heterostrophus encodes 5‐salicylate hydroxylase, converting salicylic acid (SA) to gentisic acid, enhancing pathogenicity and suppressing plant SA signalling‐mediated defences during infection. ABSTRACT Salicylic acid (SA) plays a crucial role in the defence strategies of plants against fungal pathogens.
Yadi Xu, He Wei, Haixiao Li, Fanli Zeng, Ning Liu, Zhiyan Cao, Jingao Dong   +6 more
wiley   +1 more source

Metschnikowia pulcherrima Influences the Expression of Genes Involved in PDH Bypass and Glyceropyruvic Fermentation in Saccharomyces cerevisiae

Frontiers in Microbiology, 2017
Previous studies reported that the use of Metschnikowia pulcherrima in sequential culture fermentation with Saccharomyces cerevisiae mainly induced a reduction of volatile acidity in wine. The impact of the presence of this yeast on the metabolic pathway
Mohand Sadoudi, Sandrine Rousseaux, Vanessa David, Hervé Alexandre, Raphaëlle Tourdot-Maréchal   +4 more
doaj   +1 more source

KLONING DAN EKSPRESI GEN pdc PENYANDI PYRUVATE DECARBOXYLASE DARI Zymobacter palmae [PDF]

, 2008
Gen pdc merupakan penyandi enzim pyruvate decarboxylase (PDC) yang berperan dalam proses produksi asetaldehida secara homofermentatif. Asetaldehida berperan penting dalam sintesis asam asetat, anhidrid asam asetat, butanol, etil asetat dan piridin.
Kusuma, Agitya Putra
core  

Effect of Yeast Pyruvate Decarboxylase on Ehrlich Ascites Carcinoma in vivo [PDF]

, 1966
Anna Juliane Rommel
openalex   +1 more source