Results 21 to 30 of about 933 (184)

Effect of Respiratory Growth on the Metabolite Production and Stress Robustness of Lactobacillus casei N87 Cultivated in Cheese Whey Permeate Medium

Frontiers in Microbiology, 2019
Cheese whey permeate (WP) is a low-cost feedstock used for the production of biomass and metabolites from several lactic acid bacteria (LAB) strains. In this study, Lactobacillus casei N87 was cultivated in an optimized WP medium (WPM) to evaluate the ...
Annamaria Ricciardi, Teresa Zotta, Rocco Gerardo Ianniello, Floriana Boscaino, Attilio Matera, Eugenio Parente   +5 more
doaj   +1 more source

The impact of RNA binding proteins and the associated long non-coding RNAs in the TCA cycle on cancer pathogenesis

RNA Biology, 2023
The tricarboxylic acid (TCA) cycle is a central route for generating cellular energy and precursors for biosynthetic pathways. Emerging evidences have shown that the aberrations of metabolic enzymes which affect the integrity of TCA cycle are implicated ...
Tao Shen, Haiyang Wang, Bin Tang, Guoping Zhu, Xiangting Wang   +4 more
doaj   +1 more source

Elimination of aromatic fusel alcohols as by-products of Saccharomyces cerevisiae strains engineered for phenylpropanoid production by 2-oxo-acid decarboxylase replacement

Metabolic Engineering Communications, 2021
Engineered strains of the yeast Saccharomyces cerevisiae are intensively studied as production platforms for aromatic compounds such as hydroxycinnamic acids, stilbenoids and flavonoids.
Else-Jasmijn Hassing, Joran Buijs, Nikki Blankerts, Marijke A. Luttik, Erik A.de Hulster, Jack T. Pronk, Jean-Marc Daran   +6 more
doaj  

Role of phosphate limitation and pyruvate decarboxylase in rewiring of the metabolic network for increasing flux towards isoprenoid pathway in a TATA binding protein mutant of Saccharomyces cerevisiae

Microbial Cell Factories, 2018
Background Production of isoprenoids, a large and diverse class of commercially important chemicals, can be achieved through engineering metabolism in microorganisms. Several attempts have been made to reroute metabolic flux towards isoprenoid pathway in
Manisha Wadhwa, Sumana Srinivasan, Anand K. Bachhawat, K. V. Venkatesh   +3 more
doaj   +1 more source

Transcriptome Analysis Reveals Genes Associated with Flooding Tolerance in Mulberry Plants

Life, 2023
Mulberry (Morus alba), a widely distributed economic plant, can withstand long-term flooding stress. However, the regulatory gene network underlying this tolerance is unknown.
Jingtao Hu, Yanyan Duan, Junnian Yang, Liping Gan, Wenjing Chen, Jin Yang, Guosheng Xiao, Lingliang Guan, Jingsheng Chen   +8 more
doaj   +1 more source

Conversion of Similar Xenochemicals to Dissimilar Products: Exploiting Competing Reactions in Whole-Cell Catalysis

Molecules, 2023
Many enzymes have latent activities that can be used in the conversion of non-natural reactants for novel organic conversions. A classic example is the conversion of benzaldehyde to a phenylacetyl carbinol, a precursor for ephedrine manufacture.
Francesca Sannelli, Nikoline Corell Sindahl, Stefan S. Warthegau, Pernille Rose Jensen, Sebastian Meier   +4 more
doaj   +1 more source

Translocation of Zymomonas mobilis pyruvate decarboxylase to periplasmic compartment for production of acetaldehyde outside the cytosol

MicrobiologyOpen, 2019
Acetaldehyde, a valuable commodity chemical, is a volatile inhibitory byproduct of aerobic fermentation in Zymomonas mobilis and in several other microorganisms.
Elina Balodite, Inese Strazdina, Jekaterina Martynova, Nina Galinina, Reinis Rutkis, Zane Lasa, Uldis Kalnenieks   +6 more
doaj   +1 more source

Inhibiting Glycine Decarboxylase Suppresses Pyruvate-to-Lactate Metabolism in Lung Cancer Cells

Frontiers in Oncology, 2018
Glycine decarboxylase (GLDC) gene is frequently upregulated in various types of cancer including lung, prostate and brain. It catabolizes glycine to yield 5,10-methylenetetrahydrofolate, an important substrate in one-carbon metabolism for nucleotide ...
Chern Chiuh Woo, Kavita Kaur, Wei Xin Chan, Xing Qi Teo, Teck Hock Philip Lee   +4 more
doaj   +1 more source

Vitamin-responsive movement disorders in children

Annals of Indian Academy of Neurology, 2020
Movement disorders in childhood comprise a heterogeneous group of conditions that lead to impairment of voluntary movement, abnormal postures, or inserted involuntary movements. Movement disorders in children are frequently caused by metabolic disorders,
Vishal Sondhi, Suvasini Sharma
doaj   +1 more source

A thermophilic cell-free cascade enzymatic reaction for acetoin synthesis from pyruvate

Scientific Reports, 2017
Acetoin (3-hydroxy-2-butanone) is an important bio-based platform chemical with wide applications. In vitro enzyme catalysed synthesis exhibits great feasibility in the production of chemicals with high purity.
Xiaojing Jia, Ying Liu, Yejun Han
doaj   +1 more source