Molecular mechanism of ethanol fermentation inhibition via protein tyrosine nitration of pyruvate decarboxylase by reactive nitrogen species in yeast [PDF]
Scientific Reports, 2022 Protein tyrosine nitration (PTN), in which tyrosine (Tyr) residues on proteins are converted into 3-nitrotyrosine (NT), is one of the post-translational modifications mediated by reactive nitrogen species (RNS). Many recent studies have reported that PTN
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Role of phosphate limitation and pyruvate decarboxylase in rewiring of the metabolic network for increasing flux towards isoprenoid pathway in a TATA binding protein mutant of Saccharomyces cerevisiae [PDF]
Microbial Cell Factories, 2018 Background Production of isoprenoids, a large and diverse class of commercially important chemicals, can be achieved through engineering metabolism in microorganisms. Several attempts have been made to reroute metabolic flux towards isoprenoid pathway in
Manisha Wadhwa +3 more
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Crystal structure of an inferred ancestral bacterial pyruvate decarboxylase. [PDF]
Acta Crystallogr F Struct Biol Commun, 2018 Pyruvate decarboxylase (PDC; EC 4.1.1.1) is a key enzyme in homofermentative metabolism where ethanol is the major product. PDCs are thiamine pyrophosphate- and Mg2+ion-dependent enzymes that catalyse the non-oxidative decarboxylation of pyruvate to acetaldehyde and carbon dioxide.
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Crystal structure of pyruvate decarboxylase from Zymobacter palmae [PDF]
Acta Crystallogr F Struct Biol Commun, 2016 The crystal structure of Z. palmae pyruvate decarboxylase was elucidated at 2.15 Å resolution.
Lisa Buddrus +5 more
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Zymobacter palmae Pyruvate Decarboxylase is Less Effective Than That of Zymomonas mobilis for Ethanol Production in Metabolically Engineered Synechocystis sp. PCC6803 [PDF]
Microorganisms, 2019 To produce bioethanol from model cyanobacteria such as Synechocystis, a two gene cassette consisting of genes encoding pyruvate decarboxylase (PDC) and alcohol dehydrogenase (ADH) are required to transform pyruvate first to acetaldehyde and then to ...
Lorraine Quinn +5 more
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Gold(I)-catalysed synthesis of a furan analogue of thiamine pyrophosphate [PDF]
Beilstein Journal of Organic Chemistry, 2014 An analogue of thiamine having a furan ring in place of the thiazolium ring has been synthesised by a short and efficient route, involving gold(I)-catalysed cyclisation of an alkynyl alcohol to form the furan ring.
Amjid Iqbal +2 more
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Inhibiting Glycine Decarboxylase Suppresses Pyruvate-to-Lactate Metabolism in Lung Cancer Cells
Frontiers in Oncology, 2018 Glycine decarboxylase (GLDC) gene is frequently upregulated in various types of cancer including lung, prostate and brain. It catabolizes glycine to yield 5,10-methylenetetrahydrofolate, an important substrate in one-carbon metabolism for nucleotide ...
Chern Chiuh Woo +4 more
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Functional Characterization of Waterlogging and Heat Stresses Tolerance Gene Pyruvate decarboxylase 2 from Actinidia deliciosa [PDF]
Int J Mol Sci, 2017 A previous report showed that both Pyruvate decarboxylase (PDC) genes were significantly upregulated in kiwifruit after waterlogging treatment using Illumina sequencing technology, and that the kiwifruit AdPDC1 gene was required during waterlogging, but ...
Hui Luo +6 more
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Indole pyruvate decarboxylase gene regulates the auxin synthesis pathway in rice by interacting with the indole-3-acetic acid-amido synthetase gene, promoting root hair development under cadmium stress. [PDF]
Front Plant Sci, 2022 Shah G +7 more
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Subunit size of cytoplasmic yeast pyruvate decarboxylase [PDF]
FEBS Letters, 1969 Johannes Ullrich, M. Kempfle
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