Results 31 to 40 of about 933 (184)
Frontiers in Bioengineering and Biotechnology, 2019 Tyrosol is extensively used in the pharmaceutical industry as an important natural product from plants. In this study, an exogenous pathway involved in catalyzing tyrosine to tyrosol was introduced into Saccharomyces cerevisiae. Furthermore, The pyruvate
Wei Guo +8 more
doaj +1 more source
An iterative computational design approach to increase the thermal endurance of a mesophilic enzyme
Biotechnology for Biofuels, 2018 Background Strategies for maximizing the microbial production of bio-based chemicals and fuels include eliminating branched points to streamline metabolic pathways.
Deanne W. Sammond +11 more
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Cancer Communications, EarlyView.Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cancer.
Jinghan Zhu +12 more
wiley +1 more source
Citrate Treatment in a Patient with Pyruvate Decarboxylase Deficiency
The Tohoku Journal of Experimental Medicine, 1976 A 5-year old boy with intermittent sopor, severe vomiting and ataxia since 2 1/2 years old was described. During attack period the patient showed elevation of blood pyruvate and alanine and also cerebrospinal-fluid pyruvate, whereas during the time free from attack only blood pyruvate was increased.
YOGO OKA +5 more
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Cancer Communications, EarlyView.Abstract Post‐translational modifications (PTMs) play a pivotal role in epigenetic regulation and are key pathways for modulating protein functionality. PTMs involve the covalent attachment of distinct chemical groups, such as succinyl, crotonyl, and lactyl, at specific protein sites, which alter protein structure, function, stability, and activity ...
Ting Wu +16 more
wiley +1 more source
Crystal structure of an inferred ancestral bacterial pyruvate decarboxylase [PDF]
Acta Crystallographica Section F Structural Biology Communications, 2018 Pyruvate decarboxylase (PDC; EC 4.1.1.1) is a key enzyme in homofermentative metabolism where ethanol is the major product. PDCs are thiamine pyrophosphate- and Mg2+ion-dependent enzymes that catalyse the non-oxidative decarboxylation of pyruvate to acetaldehyde and carbon dioxide.
Michael J. Danson +6 more
openaire +5 more sources
Gold(I)-catalysed synthesis of a furan analogue of thiamine pyrophosphate
Beilstein Journal of Organic Chemistry, 2014 An analogue of thiamine having a furan ring in place of the thiazolium ring has been synthesised by a short and efficient route, involving gold(I)-catalysed cyclisation of an alkynyl alcohol to form the furan ring.
Amjid Iqbal +2 more
doaj +1 more source
Biologia Plantarum, 2020 Flood in rice fields at the time of seed sowing and early seedling establishment causes extensive crop loss due to the inability of the seeds to tolerate and overcome submergence. In the present study, rice genotypes from Assam, India tolerant to hypoxia
D. KUMAR, P.K. DAS, B.K. SARMAH
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Hazelnut: Explorations toward the Biocatalytic Synthesis of its Aroma Precursor
ChemBioChem, EarlyView.This article proposes a biosynthetic route for synthesizing filbertone, the principal flavor compound of hazelnut, through a multienzyme cascade. The pathway uses D‐amino acid oxidase, threonine deaminase, and a regioselective transketolase from Geobacillus stearothermophilus to produce a sustainable, natural hazelnut aroma precursor, addressing ...
Mireia Salvadó‐Pau +3 more
wiley +1 more source
Biotechnology for Biofuels, 2018 Background The yeast Saccharomyces cerevisiae is a promising host cell for producing a wide range of chemicals. However, attempts to metabolically engineer Crabtree-positive S.
Jun Ishii +8 more
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