Results 31 to 40 of about 145,153 (320)
Redirecting Intermediary Metabolism to Counteract Cyanide Poisoning. [PDF]
FASEB JCyanide is coined “the classic metabolic poison”; however, FDA‐approved cyanide chelators do not counteract cyanide's metabolic damage. Here, we review the mechanisms of cyanide toxicity, with a focus on intermediary metabolism. We present the theory that, within the innate plasticity of the metabolome, there may reside metabolic pathways that can ...
Bebarta VS, Nath AK.
europepmc +2 more sources
Adaptive mutations in sugar metabolism restore growth on glucose in a pyruvate decarboxylase negative yeast strain [PDF]
Microb Cell Fact, 2015 BackgroundA Saccharomyces cerevisiae strain carrying deletions in all three pyruvate decarboxylase (PDC) genes (also called Pdc negative yeast) represents a non-ethanol producing platform strain for the production of pyruvate derived biochemicals ...
Yiming Zhang +7 more
semanticscholar +2 more sources
Active oligomeric states of pyruvate decarboxylase and their functional characterization [PDF]
European Journal of Biochemistry, 2001 Homomeric pyruvate decarboxylase (E.C 4.1.1.1) from yeast consists of dimers and tetramers under physiological conditions, a Kd value of 8.1 µm was determined by analytical ultracentrifugation. Dimers and monomers of the enzyme could be populated by equilibrium denaturation using urea as denaturant at defined concentrations and monitored by a ...
Margrit Killenberg‐Jabs +4 more
openalex +4 more sources
Pyruvate kinases have an intrinsic and conserved decarboxylase activity. [PDF]
Biochemical Journal, 2014 The phosphotransfer mechanism of PYKs (pyruvate kinases) has been studied in detail, but the mechanism of the intrinsic decarboxylase reaction catalysed by PYKs is still unknown.
W. Zhong +8 more
semanticscholar +5 more sources
The effect of modulating the quantity of enzymes in a model ethanol pathway on metabolic flux in Synechocystis sp. PCC 6803 [PDF]
PeerJ, 2019 Synthetic metabolism allows new metabolic capabilities to be introduced into strains for biotechnology applications. Such engineered metabolic pathways are unlikely to function optimally as initially designed and native metabolism may not efficiently ...
Paulina Bartasun +9 more
doaj +2 more sources
Redirection of the Reaction Specificity of a Thermophilic Acetolactate Synthase toward Acetaldehyde Formation. [PDF]
PLoS ONE, 2016 Acetolactate synthase and pyruvate decarboxylase are thiamine pyrophosphate-dependent enzymes that convert pyruvate into acetolactate and acetaldehyde, respectively.
Maria Cheng +4 more
doaj +1 more source
Inactivation of pyruvate decarboxylase by 3-hydroxypyruvate [PDF]
Biochemical Journal, 1990 Pyruvate decarboxylase from Zymomonas mobilis is inhibited by 3-hydroxypyruvate, which can also act as a poor substrate. While catalysing the decarboxylation of this alternative substrate, the enzyme undergoes a progressive but partial inactivation over several hours.
Thomas G., Diefenbach R., Duggleby R.G.
openaire +4 more sources
The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression
Hepatology, EarlyView., 2022 Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro +14 more
wiley +1 more source
Pyruvic decarboxylase inhibition in ketoaciduria [PDF]
Pediatric Research, 1971 A patient with intermittent episodes of cerebellar ataxia has been described (Pediat. 43:1025, 1969). The child excreted large amounts of urinary pyruvic acid during an episode which was studied in detail. Fibrobalst tissue culture cells were assayed for pyruvic decarboxylase and found to contain a low concentration of this enzyme.
Raymond J. Shamberger +3 more
openaire +1 more source
Frontiers in Microbiology, 2023 Cyanobacteria are an excellent microbial photosynthetic platform for sustainable carbon dioxide fixation. One bottleneck to limit its application is that the natural carbon flow pathway almost transfers CO2 to glycogen/biomass other than designed ...
E-Bin Gao +6 more
doaj +1 more source