Results 41 to 50 of about 933 (184)

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

A Genome-Scale Metabolic Model of Anabaena 33047 to Guide Genetic Modifications to Overproduce Nylon Monomers

Metabolites, 2021
Nitrogen fixing-cyanobacteria can significantly improve the economic feasibility of cyanobacterial production processes by eliminating the requirement for reduced nitrogen. Anabaena sp.
John I. Hendry, Hoang V. Dinh, Debolina Sarkar, Lin Wang, Anindita Bandyopadhyay, Himadri B. Pakrasi, Costas D. Maranas   +6 more
doaj   +1 more source

Bioactive polysaccharides and their potential health benefits in reducing the risks of metabolic syndrome: A review

Food Biomacromolecules, EarlyView.
Abstract Metabolic syndrome (MetS) is a complex noncommunicable condition characterized by central obesity, insulin resistance, hyperlipidemia, hypertension, and hyperglycemia. Epidemiological evidence shows that MetS affects a third of the global population; however, due to its complex pathogenesis and limited drug therapy options, the increasing ...
Josiah Owuor Oyalo, Evelyne Nkirote Gikundi, Mercy Adhiambo Ndiege, Kevin Omondi Aduol   +3 more
wiley   +1 more source

Pyruvate kinases have an intrinsic and conserved decarboxylase activity [PDF]

Biochemical Journal, 2014
The phosphotransfer mechanism of PYKs (pyruvate kinases) has been studied in detail, but the mechanism of the intrinsic decarboxylase reaction catalysed by PYKs is still unknown. 1H NMR was used in the present study to follow OAA (oxaloacetate) decarboxylation by trypanosomatid and human PYKs confirming that the decarboxylase activity is conserved ...
Iain W. McNae, Matthew W. Nowicki, Paul A.M. Michels, Paul A.M. Michels, Hugh P. Morgan, Juraj Bella, Malcolm D. Walkinshaw, Meng Yuan, Linda A. Fothergill-Gilmore, Wenhe Zhong   +9 more
openaire   +4 more sources

Molecular mechanism of ethanol fermentation inhibition via protein tyrosine nitration of pyruvate decarboxylase by reactive nitrogen species in yeast

Scientific Reports, 2022
Protein tyrosine nitration (PTN), in which tyrosine (Tyr) residues on proteins are converted into 3-nitrotyrosine (NT), is one of the post-translational modifications mediated by reactive nitrogen species (RNS). Many recent studies have reported that PTN
Supapid Eknikom, Ryo Nasuno, Hiroshi Takagi   +2 more
doaj   +1 more source

Microbial food fermentation: An extraordinary approach to improve food quality employing beneficial microbes

Food Biomacromolecules, EarlyView.
Abstract Fermentation is a biochemical process that includes the conversion of complex organic substances into different food products and beverages using microbial enzymes. The purpose of microbial fermentation is to improve the quality and safety of food.
Rameen Atique, Hafiza Arshi Saeed, Amara Ijaz, Ambreen Talib, Rabbya Rayan Shah, Ayesha Haidar, Areesha Naveed, Javeria Sharif, Ayesha Nadeem, Maryam Latif, Abia Muazzam, Ayesha Muazzam, Abdul Samad   +12 more
wiley   +1 more source

Mechanistic and Structural Insight to an Evolved Benzoylformate Decarboxylase with Enhanced Pyruvate Decarboxylase Activity [PDF]

Catalysts, 2016
Benzoylformate decarboxylase (BFDC) and pyruvate decarboxylase (PDC) are thiamin diphosphate-dependent enzymes that share some structural and mechanistic similarities. Both enzymes catalyze the nonoxidative decarboxylation of 2-keto acids, yet differ considerably in their substrate specificity. In particular, the BFDC from P.
Forest Andrews, Cindy Wechsler, Megan Rogers, Danilo Meyer, Kai Tittmann, Michael McLeish   +5 more
openaire   +3 more sources

GmPGL1, a Thiamine Thiazole Synthase, Is Required for the Biosynthesis of Thiamine in Soybean

Frontiers in Plant Science, 2019
Thiamine is an essential cofactor in several enzymatic reactions for all living organisms. Animals cannot synthesize thiamine and depend on their diet.
Xingxing Feng, Xingxing Feng, Suxin Yang, Kuanqiang Tang, Kuanqiang Tang, Yaohua Zhang, Jiantian Leng, Jingjing Ma, Jingjing Ma, Quan Wang, Quan Wang, Xianzhong Feng   +11 more
doaj   +1 more source

Substrate Activation Of Yeast Pyruvate Decarboxylases

, 2007
Short presentation for winning a poster award (Enzymes in motion - substrate activation of yeast pyruvate decarboxylases I. Crystal structures, 10.5281/zenodo.1313834) during the 7th international conference on mechanism and physiology of thiamine, Wittenberg, Germany, 05/29/2008-06/01/2008 Held on 06/01/2018, 11.25 am, https://dechema.de ...
openaire   +3 more sources

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source