Results 71 to 80 of about 145,153 (320)

A thermophilic cell-free cascade enzymatic reaction for acetoin synthesis from pyruvate

Scientific Reports, 2017
Acetoin (3-hydroxy-2-butanone) is an important bio-based platform chemical with wide applications. In vitro enzyme catalysed synthesis exhibits great feasibility in the production of chemicals with high purity.
Xiaojing Jia, Ying Liu, Yejun Han
doaj   +1 more source

Covalently bound substrate at the regulatory site triggers allosteric enzyme activation [PDF]

, 2008
The mechanism by which the enzyme pyruvate decarboxylase from yeast is activated allosterically has been elucidated. A total of seven three-dimensional structures of the enzyme, of enzyme variants or of enzyme complexes form two yeast species (three of ...
Georg Wille, Manfred Weiss, Michael Spinka, Ralph Golbik, Steffen Kutter, Stephan Kö   +5 more
core   +1 more source

Occurrence of thiamin pyrophosphate-dependent 2-oxoglutarate decarboxylase in mitochondria of Euglena gracilis [PDF]

, 1986
2-Oxoglutarate decarboxylase which catalyzes the conversion of 2-oxoglutarate into succinate semialdehyde occurs in mitochondria of Euglena gracilis which lacks a 2-oxoglutarate dehydrogenase complex.
Kitaoka, Shozaburo, Maeda, Kozi, Nakano, Yoshihisa, Onishi, Toshio, Shigeoka, Shigeru   +4 more
core   +1 more source

Tailoring a Functional Synthetic Microbial Community Alleviates Fusobacterium nucleatum‐infected Colorectal Cancer via Ecological Control

Advanced Science, EarlyView.
The bottom‐up strategy based on multiomics data is used for the SynCom design, and it successfully inhibited F. nucleatum growth and achieved stable colonization in vivo. In addition, it promoted tryptophan metabolism and secondary bile acid conversion, reduced lipid accumulation, relieved microbiome disorder, decreased inflammatory reaction, and ...
Zhongkun Zhou, Mengyue Yang, Hong Fang, Baizhuo Zhang, Yunhao Ma, Yongyuan Li, Yingjie Liu, Zeying Cheng, Yuanchun Zhao, Zhenzhen Si, Hongmei Zhu, Peng Chen   +11 more
wiley   +1 more source

An iterative computational design approach to increase the thermal endurance of a mesophilic enzyme

Biotechnology for Biofuels, 2018
Background Strategies for maximizing the microbial production of bio-based chemicals and fuels include eliminating branched points to streamline metabolic pathways.
Deanne W. Sammond, Noah Kastelowitz, Bryon S. Donohoe, Markus Alahuhta, Vladimir V. Lunin, Daehwan Chung, Nicholas S. Sarai, Hang Yin, Ashutosh Mittal, Michael E. Himmel, Adam M. Guss, Yannick J. Bomble   +11 more
doaj   +1 more source

Identification of novel hypoxia-responsive factors in deep-water rice conferring tolerance to flood during germination

Biologia Plantarum, 2020
Flood in rice fields at the time of seed sowing and early seedling establishment causes extensive crop loss due to the inability of the seeds to tolerate and overcome submergence. In the present study, rice genotypes from Assam, India tolerant to hypoxia
D. KUMAR, P.K. DAS, B.K. SARMAH
doaj   +1 more source

Evolutionary analysis of the TPP-dependent enzyme family [PDF]

, 2008
The evolutionary relationships of the thiamine pyrophosphate (TPP)-dependent family of enzymes was investigated by generation of a neighbor joining phylogenetic tree using sequences from the conserved pyrophosphate (PP) and pyrimidine (Pyr) binding ...
Costelloe, S.J., Dalby, P.A., Ward, J.M.
core  

Structural classification of biotin carboxyl carrier proteins [PDF]

, 2012
We gathered primary and tertiary structures of acyl-CoA carboxylases from public databases, and established that members of their biotin carboxylase (BC) and biotin carboxyl carrier protein (BCCP) domains occur in one family each and that members of ...
Cantu, David, Chen, Yingfei, Elizondo-Noriega, Armando, Reilly, Peter, Reilly, Peter   +4 more
core   +3 more sources

Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma

Cancer Communications, EarlyView.
Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cancer.
Jinghan Zhu, Yixiao Xiong, Yuxin Zhang, Huifang Liang, Kun Cheng, Yuanxiang Lu, Guangzhen Cai, Yang Wu, Yunhui Fan, Xiaoping Chen, Hong Zhu, Zeyang Ding, Wanguang Zhang   +12 more
wiley   +1 more source

A pyruvate carbon flux tugging strategy for increasing 2,3-butanediol production and reducing ethanol subgeneration in the yeast Saccharomyces cerevisiae

Biotechnology for Biofuels, 2018
Background The yeast Saccharomyces cerevisiae is a promising host cell for producing a wide range of chemicals. However, attempts to metabolically engineer Crabtree-positive S.
Jun Ishii, Keisuke Morita, Kengo Ida, Hiroko Kato, Shohei Kinoshita, Shoko Hataya, Hiroshi Shimizu, Akihiko Kondo, Fumio Matsuda   +8 more
doaj   +1 more source