The PEP—pyruvate—oxaloacetate node as the switch point for carbon flux distribution in bacteria: We dedicate this paper to Rudolf K. Thauer, Director of the Max-Planck-Institute for Terrestrial Microbiology in Marburg, Germany, on the occasion of his 65th birthday [PDF]
, 2017 In many organisms, metabolite interconversion at the phosphoenolpyruvate (PEP)-pyruvate-oxaloacetate node involves a structurally entangled set of reactions that interconnects the major pathways of carbon metabolism and thus, is responsible for the ...
Eikmanns, Bernhard J., Sauer, Uwe
core
, 2006 Buchnera aphidicola, the primary endosymbiont of aphids, has undergone important genomic and biochemical changes as an adaptation to intracellular life.
Gil, Rosario +4 more
core +1 more source
Investigation of Metabolism of Exogenous Glucose at the Early Stage and Onset of Diabetes Mellitus in Otsuka Long-Evans Tokushima Fatty Rats Using [1, 2, 3-13C]Glucose Breath Tests. [PDF]
PLoS ONE, 2016 This study aimed to evaluate changes in glucose metabolism at the early stage and onset of diabetes in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Specifically, after the oral administration of [1, 2, 3-13C]glucose, the levels of exhaled 13CO2, which
Naoyuki Kawagoe +5 more
doaj +1 more source
Engineering of the Thiamine Diphosphate‐Dependent JanthE for the Synthesis of Tertiary Alcohols
Chemistry – A European Journal, EarlyView.The synthesis of chiral tertiary alcohols is in high demand. Here we investigate in detail the aldehyde–ketone cross‐coupling reactions catalyzed by the promising thiamine diphosphate‐dependent lyase JanthE. Focusing on both reaction parameters and engineering, we rationally develop JanthE to improve its applicability and demonstrate its evolvability ...
Lucrezia Lanza +7 more
wiley +1 more source
The Role of Biotin and Oxamate in the Carboxyltransferase Reaction of Pyruvate Carboxylase [PDF]
, 2014 Pyruvate carboxylase (PC) is a biotin-dependent enzyme that catalyzes the MgATP-dependent carboxylation of pyruvate to oxaloacetate, an important anaplerotic reaction in central metabolism.
Lietzan, Adam D. +2 more
core +2 more sources
Molecular Fragmentation as a Strategy to Access Hyperpolarized Compounds from Para‐Hydrogen
ChemPhysChem, EarlyView.Hyperpolarization using para‐hydrogen is a simple and cost‐effective method to dramatically increase sensitivity in magnetic resonance. When combined with chemical reactions that generate smaller fragments, a much wider array of different hyperpolarized molecules can be accessed.
Philip L. Norcott
wiley +1 more source
, 2004 Intracellular symbiosis is very common in the insect world. For the aphid Cinara cedri, we have identified by electron microscopy three symbiotic bacteria that can be characterized by their different sizes, morphologies, and electrodensities.
García-Verdugo, José Manuel +6 more
core +2 more sources
Towards an integrative model of C4 photosynthetic subtypes: insights from comparative transcriptome analysis of NAD-ME, NADP-ME, and PEP-CK C-4 species [PDF]
, 2014 C4 photosynthesis affords higher photosynthetic carbon conversion efficiency than C3 photosynthesis and it therefore represents an attractive target for engineering efforts aiming to improve crop productivity.
Andrea Bräutigam +5 more
core +2 more sources
Journal of the Science of Food and Agriculture, EarlyView.Abstract BACKGROUND Livestock production contributes largely to climate change and methane (CH4) from enteric fermentation is the primary greenhouse gas emitted from ruminants. Thus, developing effective strategies to reduce the impact of ruminant production on the environment is crucial, and the combination of CH4 mitigating agents may be a viable ...
Jamal James D. Manlapig +4 more
wiley +1 more source
Mutual-Information Based Optimal Experimental Design for Hyperpolarized $^{13}$C-Pyruvate MRI [PDF]
arXiv, 2022 A key parameter of interest recovered from hyperpolarized (HP) MRI measurements is the apparent pyruvate-to-lactate exchange rate, $k_{PL}$, for measuring tumor metabolism. This manuscript presents an information-theory-based optimal experimental design (OED) approach that minimizes the uncertainty in the rate parameter, $k_{PL}$, recovered from HP-MRI
arxiv