Results 91 to 100 of about 9,999 (176)

Adipose tissue NAD(+)-homeostasis, sirtuins and poly(ADP-ribose) polymerases - important players in mitochondrial metabolism and metabolic health [PDF]

, 2017
Obesity, a chronic state of energy overload, is characterized by adipose tissue dysfunction that is considered to be the major driver for obesity associated metabolic complications.
Jokinen, Riikka, Pietilainen, Kirsi H., Pirinen, Eija, Pirnes-Karhu, Sini   +3 more
core   +2 more sources

Lactylation: From Homeostasis to Pathological Implications and Therapeutic Strategies

MedComm, Volume 6, Issue 6, June 2025.
Lactylation, a novel post‐translational modification derived from lactate metabolism, plays a critical role in cellular homeostasis and disease pathogenesis. Under physiological conditions, lactylation regulates gene expression, immune responses, and metabolic adaptation. However, dysregulated lactylation is implicated in various pathological processes,
Xi Chen, Yixiao Yuan, Fan Zhou, Lihua Li, Jun Pu, Yong Zeng, Xiulin Jiang   +6 more
wiley   +1 more source

Molecular basis of autotrophic vs mixotrophic growth in Chlorella sorokiniana [PDF]

, 2018
In this work, we investigated the molecular basis of autotrophic vs. mixotrophic growth of Chlorella sorokiniana, one of the most productive microalgae species with high potential to produce biofuels, food and high value compounds.
Ballottari, M, Benfatto, S, Cazzaniga, S, Cecchin, M, Delledonne, M, Griggio, F, Mori, A, Vitulo, N   +7 more
core   +2 more sources

Metformin use in women with polycystic ovary syndrome (PCOS): Opportunities, benefits, and clinical challenges

Diabetes, Obesity and Metabolism, Volume 27, Issue S3, Page 31-47, June 2025.
Abstract Metformin, a synthetic biguanide, is widely used to manage type 2 diabetes, and is commonly prescribed in polycystic ovary syndrome (PCOS) to address insulin resistance and associated metabolic and reproductive disturbances. PCOS is characterised by hormonal imbalances such as hyperandrogenism and anovulation, metabolic abnormalities including
Saeede Saadati, Taitum Mason, Rasoul Godini, Eszter Vanky, Helena Teede, Aya Mousa   +5 more
wiley   +1 more source

Neural Metabolic Networks: Key Elements of Healthy Brain Function

Journal of Neurochemistry, Volume 169, Issue 6, June 2025.
This review originated from the Fourth International Society for Neurochemistry (ISN) and Journal of Neurochemistry (JNC) Flagship School (2022). Here, we describe how the specific bioenergetic profiles and metabolic exchanges between brain cells enable and gate synaptic function and behavior. Then, based on this analysis, we discuss the potential role
Nimrod Madrer, Nirma D. Perera, Nonthué A. Uccelli, Alice Abbondanza, Jens V. Andersen, Emma Veronica Carsana, Matthew D. Demmings, Regina F. Fernandez, Matheus Garcia de Fragas, Ismail Gbadamosi, Divita Kulshrestha, Ricardo A. S. Lima‐Filho, Oana C. Marian, Kia H. Markussen, Andrew J. McGovern, Elliott S. Neal, Sukanya Sarkar, Eva Šimončičová, Jazmín Soto‐Verdugo, Sozerko Yandiev, Ignacio Fernández‐Moncada   +20 more
wiley   +1 more source

Metabolomics in cardiometabolic diseases: Key biomarkers and therapeutic implications for insulin resistance and diabetes

Journal of Internal Medicine, Volume 297, Issue 6, Page 584-607, June 2025.
Abstract Cardiometabolic diseases—including Type 2 diabetes and obesity—remain leading causes of global mortality. Recent advancements in metabolomics have facilitated the identification of metabolites that are integral to the development of insulin resistance, a characteristic feature of cardiometabolic disease. Key metabolites, such as branched‐chain
David Rizo‐Roca, John D. Henderson, Juleen R. Zierath   +2 more
wiley   +1 more source

Identification of Prognostic Biomarkers for Stage III Non-Small Cell Lung Carcinoma in Female Nonsmokers Using Machine Learning [PDF]

arXiv
Lung cancer remains a leading cause of cancer-related deaths globally, with non-small cell lung cancer (NSCLC) being the most common subtype. This study aimed to identify key biomarkers associated with stage III NSCLC in non-smoking females using gene expression profiling from the GDS3837 dataset.
arxiv  

ChnagG Plays the Role of 5‐Salicylate Hydroxylase in the Gentisic Acid Pathway of Salicylic Acid Metabolism in Cochliobolus heterostrophus

Molecular Plant Pathology, Volume 26, Issue 6, June 2025.
The ChnagG gene in Cochliobolus heterostrophus encodes 5‐salicylate hydroxylase, converting salicylic acid (SA) to gentisic acid, enhancing pathogenicity and suppressing plant SA signalling‐mediated defences during infection. ABSTRACT Salicylic acid (SA) plays a crucial role in the defence strategies of plants against fungal pathogens.
Yadi Xu, He Wei, Haixiao Li, Fanli Zeng, Ning Liu, Zhiyan Cao, Jingao Dong   +6 more
wiley   +1 more source

Development of a Mouse Model of Uremic Cardiomyopathy: Investigating the Impact of Chronic Kidney Disease on Cardiac Function and Signaling Pathway

The FASEB Journal, Volume 39, Issue 10, 31 May 2025.
Molecular changes in a mouse model of uremic cardiomyopathy. This model of 2,8‐DHA‐induced nephropathy in 129/Sv mice showed clinical features of uremic cardiomyopathy like reduced cardiac function and cardiac interstitial fibrosis and an unfavorable balance between protective and detrimental cardiac signaling.
Julia Moellmann, Katja Glandien, Barbara M. Klinkhammer, Julia Wollenhaupt, Heidi Noels, Joachim Jankowski, Corinna Lebherz, Peter Boor, Michael Lehrke, Nikolaus Marx   +9 more
wiley   +1 more source

Cardiolipin Is Required For Optimal Acetyl-Coa Metabolism [PDF]

, 2016
The phospholipid cardiolipin (CL) is crucial for many cellular functions and signaling pathways, both inside and outside of mitochondria. My thesis focuses on the role of CL in energy metabolism.
Raja, Vaishnavi
core   +1 more source