Results 81 to 90 of about 9,755 (167)
Regulation of Protein Degradation in the Heart by AMP-Activated Protein Kinase [PDF]
, 2012 The degradation of proteins by the ubiquitin proteasome system is essential for cellular homeostasis in the heart. An important regulator of metabolic homeostasis is AMP-activated protein kinase (AMPK).
Baskin, Kedryn K, Baskin, Kedryn K
core
Exploration, Volume 6, Issue 2, April 2026.EnzRetro bridges retrosynthesis planning and enzymatic engineering through site‐specific reaction edits. This end‐to‐end framework integrates pathway synthesis and enzyme identification into a unified process, achieving superior accuracy and enabling the efficient reconstruction of diverse biosynthetic pathways.
Yahui Cao +5 more
wiley +1 more source
International Journal of Cancer, Volume 158, Issue 7, Page 1927-1940, 1 April 2026.What's new? Endocrine drugs repurposed from treatment protocols are the primary medications available for breast cancer (BC) prevention in at‐risk women. Adverse effects, however, significantly minimize uptake and prevention impact. Here, the authors investigated licochalcone A (LicA), a non‐endocrine anti‐inflammatory agent with reported hematologic ...
Atieh Hajirahimkhan +14 more
wiley +1 more source
Acetyl‐Phosphate Dependent Protein Acetylation in Neisseria gonorrhoeae
MicrobiologyOpen, Volume 15, Issue 2, April 2026.The role of acetyl‐phosphate‐dependent non‐enzymatic protein acetylation in Neisseria gonorrhoeae was investigated through the deletion of the phosphotransacetylase (pta) and the acetate kinase (ackA) genes, this led to a decrease and increase in protein acetylation, respectively.
Ernesto F. D. Parga +6 more
wiley +1 more source
Analyzing Nicotine Action Against Amyloid Toxicity by NMR‐Pharmacometabolomics: An Exploratory Study
NMR in Biomedicine, Volume 39, Issue 4, April 2026.Combined metabolomic analysis of the intracellular and extracellular portions of SH‐SY5Y cells revealed that, in the presence of Aβ 1–42, nicotine primarily influences pathways related to neurotransmission, energy metabolism, as well as the biosynthesis and degradation of membrane phospholipids.
Enza Napolitano +5 more
wiley +1 more source
Phytotherapy Research, Volume 40, Issue 4, Page 1970-2002, April 2026.ABSTRACT Psychological stress (or simply “stress”) is a major contributor to chronic disease worldwide, affecting 35% of the global population, including younger generations. Furthermore, it plays a significant role in human premature aging; hence, its detrimental effects on people's health compel us to comprehend and control the ways in which ...
Marco Duarte +3 more
wiley +1 more source
Bacterial Cellulose Synthase Catalyzes the Formation of Chitin
ChemistrySelect, Volume 11, Issue 15, 20 April 2026.Recombinant BcsA‐B from Rhodobacter sphaeroides is shown to cleave UDP‐GlcNAc (uridine diphosphate N‐acetylglucosamine), generating chitin with distinct β‐chitin Raman bands. These findings reveal that a cellulose synthase can process an alternative nucleotide sugar, providing biochemical evidence for the co‐synthesis of cellulose and chitin.
Neraz Shai +3 more
wiley +1 more source
Environmental Microbiology, Volume 28, Issue 4, April 2026.Moorella thermoacetica is the model organism for elucidation of acetogenesis. The reduction of CO2 to acetate is well studied, but how redox carrier balancing and energy conservation are maintained during autotrophic growth and how H2 is oxidised remains enigmatic.
Florian P. Rosenbaum +3 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 7, Page 1578-1601, April 2026.Background and Purpose Human adenovirus (HAdV) causes respiratory or gastrointestinal tract infections depending on the virus subtype. While HAdV infections are generally self‐limiting in immunocompetent people, they can result in significant morbidity and mortality in immunocompromised adults and children.
Mohamed Zamzamy +16 more
wiley +1 more source
The return of metabolism: biochemistry and physiology of glycolysis
Biological Reviews, Volume 101, Issue 2, Page 751-803, April 2026.ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning +19 more
wiley +1 more source