Results 81 to 90 of about 4,380 (169)

VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism

, 2017
Exacerbation of macrophage-mediated inflammation contributes to pathogenesis of various inflammatory diseases, but the immunometabolic programs underlying regulation of macrophage activation are unclear.
Chengying Yang, Lixin Zheng, Yongwen Chen, Weiming Yan, Qin Ning, Yuzhang Wu, Sheng Guo, Xiaoyong Huang, Zeqing Feng, Jialin Li, Bo Diao   +10 more
core   +1 more source

Targeting Mitochondria in Aging‐Related Diseases: Therapeutic Potential and Obstacles

MedComm, Volume 7, Issue 6, June 2026.
This article systematically summarized the specific mechanism of aging‐related diseases caused by mitochondrial dysfunction, and summarized the broad‐spectrum treatment methods and disease targeted treatment strategies for mitochondria. At the same time, it also pointed out the dilemma faced by mitochondrial targeted treatment.
Zijie Xiang, Yu Chen, Xishui Liu, Haowen Lu, Yuqing Yang, Lei Xing, Yu Zhang, Chuandong Lang, Siming Zhang, Shixiang Zhao, Youzhi Hong, Jiaxiang Bai, Yusen Qiao   +12 more
wiley   +1 more source

Pyruvate Dehydrogenase-Dependent Metabolic Programming Affects the Oligodendrocyte Maturation and Remyelination

, 2023
The metabolic needs of the premature/premyelinating oligodendrocytes (pre-OLs) and mature oligodendrocytes (OLs) are distinct. The metabolic control of oligodendrocyte maturation from the pre-OLs to the OLs is not fully understood. Here, we show that the
Giri, Shailendra, Cerghet, Mirela, Zahoor, Insha, Rashid, Faraz, Mir, Sajad, Rattan, Ramandeep   +5 more
core  

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

Acute activation of pyruvate dehydrogenase increases glucose oxidation in muscle without changing glucose uptake

, 2018
Pyruvate dehydrogenase (PDH) activity is a key component of the glucose/fatty acid cycle hypothesis for the regulation of glucose uptake and metabolism.
Lake-Ee Quek, James R. Krycer, Amanda E. Brandon, Nigel Turner, Lewin Small, David E. James, Gregory J. Cooney   +6 more
core   +1 more source

Aphid alarm pheromone (E)‐β‐farnesene: mechanisms, applications, and challenges in pest management

New Plant Protection, Volume 3, Issue 2, June 2026.
This review highlights the advances in the application of the aphid alarm pheromone (E)‐β‐farnesene (EβF) for pest management. It focuses on smart delivery systems, molecular optimization, synthetic biology, and integration with digital agriculture. Additionally, it discusses key challenges and future directions for enhancing stability, field efficacy,
Yi Yan, Yunhui Zhang, Xuguo Zhou, Xiangrui Li   +3 more
wiley   +1 more source

Expression of proteins involved in metabolism. All values are arbitrary units normalized to total protein levels (for phosphorylated proteins) or total protein staining as described in the methods.

, 2015
Molecular weights are noted. Values are means±SEM. PKM2, pyruvate kinase M2 isoform; LDHA, lactate dehydrogenase A; ACC, acetyl-CoA carboxylase; p-ACC, phospho-ACC; PDH, pyruvate dehydrogenase; p-PDH, phospho-PDH; HXKII, hexokinase II; MCD, malonyl-CoA ...
Masaki Kajimoto (419508), Lincoln Smith (782482), Dolena Ledee (419506), Nancy Isern (419509), Michael A. Portman (419507), Margaret Bruce (782483), Aaron K. Olson (419510)   +6 more
core   +1 more source

Harnessing energy metabolism for enhanced bone defect repair: Mechanisms and therapeutic strategies

VIEW, Volume 7, Issue 3, June 2026.
This review addresses the critical challenge of bone defect repair by focusing on the underexplored role of cellular energy metabolism. It synthesizes regulatory mechanisms in bone‐forming cells and sums up innovative strategies—leveraging cell derivatives, active factors, and biomimetic scaffolds—to modulate metabolism for enhanced regeneration.
Junting Li, Yulan Liu, Yuran Li, Yingjie Hua, Xinquan Jiang, Mingliang Zhou   +5 more
wiley   +1 more source

Carbon metabolism linked P solubilization in (A) glucose and (B) succinate or glucose+succinate-grown Klebsiella pneumoniae SM6 and SM11.

, 2015
Glucose is metabolized by EMP pathway and acetate is overproduced, which can be then activated to acetyl-CoA. Acetyl-CoA is incorporated in the TCA and the glyoxylate shunt. During growth on succinate, gluconeogenesis is required for the formation of PEP
Mahendrapal Singh Rajput (797658), Maharshi Pandya (797660), Shalini Rajkumar (797663), Naresh Kumar G (797662), Rahul Jog (797661), Bhagya Iyer (797659)   +5 more
core   +1 more source

Modulation of KATP channels by diazoxide preserves mitochondrial function and barrier integrity under staurosporine‐induced epithelial stress

British Journal of Pharmacology, Volume 183, Issue 12, Page 3213-3233, June 2026.
Background and Purpose Intestinal barrier dysfunction caused by mitochondrial stress, oxidative damage and apoptosis, are hallmarks of dysbiosis‐associated gastrointestinal (GI) disorders. Staurosporine causes downstream features of dysbiosis‐induced epithelial damage.
Fatima Maqoud, Eleonora Malerba, Simona Drago, Antonella Orlando, Domenica Mallardi, Nicoletta De Lucia, Marina Antonacci, Annamaria Di Turi, Domenico Tricarico, Francesco Russo   +9 more
wiley   +1 more source