Results 91 to 100 of about 9,755 (167)

Inactivation of CDK12 Enhances Mitochondrial Efficiency to Suppress DNA Damage

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Inactivation of cyclin‐dependent kinase 12 (CDK12) characterizes a subset of prostate cancers but it is not understood how cells adapt to declining activity of this major transcription elongation kinase. To probe this response, we developed a cell line resistant to an inhibitor targeting CDK12 and its paralog, CDK13.
Aishwarya Gondane, Shivani Yalala, Jing Liang, Sonja Saira, Harri M. Itkonen   +4 more
wiley   +1 more source

Multi‐Omics Combined With Mitochondrial Feeding Assays Reveal a Novel Energy Metabolism Strategy for Floral Thermogenesis in Magnolia Driven by Synergistic Supply of Multiple Substrates

Plant Biotechnology Journal, Volume 24, Issue 4, Page 2169-2183, April 2026.
ABSTRACT The high demand for energy during floral thermogenesis drives the synergistic operation of multiple energy substrates for the rapid temperature rise and successful reproduction of flowers. However, how thermogenic plants precisely regulate substrate supply and metabolic pathways within a short time to support large‐scale energy and heat ...
Siqin Wang, Jiying Li, Zhang Wang, Miao Yu, Chang Liu, Dongye Liu, Ruohan Wang   +6 more
wiley   +1 more source

Exercise training induces mitochondrial biogenesis, while high‐fat diet increases the ability of mitochondria to use long and short‐chain fatty acids

The Journal of Physiology, Volume 604, Issue 8, Page 3363-3378, 15 April 2026.
Abstract figure legend Despite a low baseline capacity for mitochondria to utilize short‐chain fatty acid (SCFA) to support oxidative phosphorylation, high‐fat diet (HFD) consumption rewired mitochondria to enhance both long‐chain and SCFA utilization, with these responses prevented by exercise training.
Jessica L. Dowling, Rachel M. Handy, Nicole M. Notaro, Sara M. Frangos, David J. Dyck, Graham P. Holloway   +5 more
wiley   +1 more source

2-MCPD-Induced Effects in the Heart: Toxicological and Mechanistic Implications from Comparative Proteomic Analyses in Rats. [PDF]

Molecules
Oberemm A, Eisenreich A, Sommerkorn K, Reinhold A, Meckert C, Götz ME.   +5 more
europepmc   +1 more source

Comparative proteomics of bark and xylem provides insights into age-dependent corticular photosynthesis in <i>Eucalyptus grandis</i>. [PDF]

Front Plant Sci
da Silva FAR, de Lima DC, Labate MTV, Budzinski IGF, Cataldi TR, Labate CA.   +5 more
europepmc   +1 more source

Advances in synthetic biology for engineering methylotrophic microbial cell factories. [PDF]

J Bacteriol
Guo L, Li R, Gao X, Zhao L, Zhang H.
europepmc   +1 more source

Classical Food Fermentations as Modern Biotechnological Platforms: Alcoholic, Acetic, Butyric, Lactic and Propionic Pathways and Applications. [PDF]

Molecules
Rymuszka A, Gorczynska W.
europepmc   +1 more source

The controversial role of metabolic reprogramming in anti-tumor therapy resistance. [PDF]

Discov Oncol
Xu Y, Wang Y, Fu Q, Yao Y, Zhou Y.
europepmc   +1 more source

Lactylation enzymes in cancer: Mechanisms and novel therapeutic approaches (Review). [PDF]

Oncol Lett
Tang G, Zuo H, Long R, Zhang C, Lv Y, Luo X, Qiu J, Zuo J.   +7 more
europepmc   +1 more source

Targeting Endothelial PDK4-EndoMT Feedback Loop Mitigates the Development of Thoracic Aortic Dissection in Mice. [PDF]

Arterioscler Thromb Vasc Biol
Cao X, Guo X, Huang H, Shen H, Zhu J, Gao Y, Liu A, Wang T, Xue Z, Tang C, Ye L, Shao L, Yu Y, Shen Z.   +13 more
europepmc   +1 more source