Results 91 to 100 of about 4,380 (169)

The Unsolved Pathogenesis of Idiopathic Ketotic Hypoglycemia:Involvement of the Pyruvate Dehydrogenase Kinase Isoenzyme 4 Gene?

open access: yes, 2011
Background and aim Ketotic hypoglycemia (KH) is the most common cause of hypoglycemia in childhood, among non-diabetic children. KH is defined by episodes of hypoglycemia with high ketone levels in plasma and urine, provoked by periods of fasting, often ...
Cung, Th.
core  

Cannabidiol and cannabigerol ameliorate steatotic liver disease via phosphocreatine buffering and lysosomal restoration

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 12, Page 3173-3194, June 2026.
Cannabidiol (CBD) and cannabigerol (CBG) alleviate hepatic steatosis in obese mice by shifting energy buffering towards phosphocreatine and enhancing lysosomal lipid degradation and trafficking. These effects are associated with increased creatine kinase activity and lysobisphosphatidic acid (LBPA) levels, highlighting a previously unrecognised ...
Radka Kočvarová   +12 more
wiley   +1 more source

Multifunctional Role of Mitochondrial Fatty Acid Oxidation in Cancer Immunotherapy and Aging

open access: yesCancer Science, Volume 117, Issue 6, Page 1554-1565, June 2026.
Recent studies have highlighted the complex interplay between tumor immunity, aging, and inflammation. Mitochondrial FAO is a major hub of this physiological interplay. ABSTRACT Recent studies have demonstrated the intricate relationship between tumor immunity, aging, and inflammation.
Koji Kitaoka   +4 more
wiley   +1 more source

Altitude‐Associated Divergence of the Gut Microbiome in Endangered Forest Musk Deer: Evidence From Integrated Metagenomics, Metabolomics, and Culturomics

open access: yesEvolutionary Applications, Volume 19, Issue 6, June 2026.
ABSTRACT High‐altitude environments expose mammals and their gut symbionts to multifaceted stressors—hypoxia, cold, and intense UV radiation. Whether gut microbial communities undergo compositional restructuring in response to these stressors, and whether such restructuring carries translational value for captive conservation, remain unresolved ...
Feiyun Huang   +12 more
wiley   +1 more source

Energetic stress in combination with impaired fatty acid oxidation induces sequestration of CoA and adaptation of CoA metabolism

open access: yesThe FEBS Journal, Volume 293, Issue 12, Page 3565-3587, June 2026.
Computational modelling and in vitro liver cell experiments indicate that medium‐chain acyl‐CoA dehydrogenase (MCAD) deficiency causes an accumulation of (especially medium‐chain) acyl‐CoAs at the cost of free CoA (CoASH). A substantial decrease in CoASH impairs flux through many pathways essential for energy homeostasis.
Ligia Akemi Kiyuna   +17 more
wiley   +1 more source

Strict Aerobic Lifestyle and Anaerobic Survival of Bacteria: Inseparable Twins?

open access: yesMolecular Microbiology, Volume 125, Issue 6, Page 546-551, June 2026.
ABSTRACT For many decades the existence of strict aerobic bacteria was part of every textbook. However, considering habitats like soils or surfaces, many of these microorganisms are exposed to drastic changes in oxygen tension. A simple rain shower can change oxygen diffusion rates by a factor of 10.000.
Meina Neumann‐Schaal   +2 more
wiley   +1 more source

Host‐Induced Silencing of Rhizoctonia Solani 5‐Enolpyruvylshikimate‐3‐Phosphate Synthase Impairs Its Virulence in Rice

open access: yesPlant Biotechnology Journal, Volume 24, Issue 6, Page 3573-3593, June 2026.
ABSTRACT Sheath blight disease of rice caused by the fungal pathogen R. solani AG1‐IA remains a big threat to rice production worldwide. A limited genetic variation in rice for tolerance to this pathogen and little success in understanding how it defeats host defence are major reasons behind it.
Vinod Kumar   +5 more
wiley   +1 more source

Aerobic Metabolism of Glucose by Facultative Anaerobe Sporolactobacillus inulinus

open access: yes, 1996
Although facultative anaerobe Sporolactobacillus inulinus lacks electron transport chain, this genus grow well under aerobic condition the same as anaerobic culture and final metabolic product on aerobic condition is only acetic acid instead of lactic ...
Kozaki, Michio   +11 more
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Carbohydrate and lipid metabolism in insulin resistant states and the development of in vivo magnetic resonance spectroscopic techniques for the analysis of gluconeogenesis and glycogen synthesis

open access: yes, 1995
PhDThis thesis will provide new information on carbohydrate and lipid metabolic control in various related physiological states both in vitro and in vivo in the rat model.
Changani, K.K., Changani, Kishore Kumar
core  

Pyruvate dehydrogenase kinase 4 inhibition or deletion in alpha-cells enhances glucagon secretion at low glucose in mouse and human islets and improves glucose tolerance in diet-induced obese male mice

open access: yes
BACKGROUND AND AIMS: The mechanisms of control of glucagon secretion are still largely unknown. In particular, it is unclear why glucose inhibits glucagon secretion while fatty acids stimulate it.
Butaye, François   +2 more
core  

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