Results 61 to 70 of about 4,126 (159)

Acute activation of pyruvate dehydrogenase increases glucose oxidation in muscle without changing glucose uptake.

American Journal of Physiology. Endocrinology and Metabolism, 2018
Pyruvate dehydrogenase (PDH) activity is a key component of the glucose/fatty acid cycle hypothesis for the regulation of glucose uptake and metabolism.
Lewin Small, A. Brandon, L. Quek, J. Krycer, D. James, N. Turner, G. Cooney   +6 more
semanticscholar   +1 more source

Placental mitochondrial metabolic adaptation maintains cellular energy balance in pregnancy complicated by gestational hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Placental mitochondrial adaptation to gestational hypoxia. Hypoxic pregnancy in sheep increases placental insulin like growth factor 2 (IGF2) signalling (1), which is associated with a shift in capacity away from β‐oxidation (2) and complex I‐mediated respiration (3), while maintaining total oxidative phosphorylation capacity (4).
Wen Tong, Beth J. Allison, Kirsty L. Brain, Olga V. Patey, Youguo Niu, Kimberley J. Botting, Sage G. Ford, Tess A. Garrud, Peter F. B. Wooding, Qiang Lyu, Lin Zhang, Jin Ma, Alice P. Sowton, Katie A. O'Brien, Tereza Cindrova‐Davies, Hong Wa Yung, Graham J. Burton, Andrew J. Murray, Dino A. Giussani   +18 more
wiley   +1 more source

Cellular Senescence in Cancer: Mechanisms, Roles in Tumor Progression, and Therapeutic Implications

MedComm – Oncology, Volume 4, Issue 3, September 2025.
Senescent tumor cells in TME exhibit dual roles. “Angels” secrete SASPs/DAMPs to boost immunological clearance and antitumor immunity via MHC‐I upregulation; “Demons” produce tumor‐promoting SASPs recruiting MDSCs to drive malignancy. ABSTRACT Cellular senescence, a state of irreversible cell cycle arrest accompanied by a senescence‐associated ...
Jingrui Yan, Yu Zhang, Guohua Mao, Jun Yu, Tianxing Zhou, Jihui Hao   +5 more
wiley   +1 more source

Regulation of Pyruvate Dehydrogenase Kinase 4 (PDK4) by CCAAT/Enhancer-binding Protein β (C/EBPβ)

Journal of Biological Chemistry, 2011
The conversion of pyruvate to acetyl-CoA in mitochondria is catalyzed by the pyruvate dehydrogenase complex (PDC). Activity of PDC is inhibited by phosphorylation via the pyruvate dehydrogenase kinases (PDKs).
Ramy Attia, Pragya Sharma, R. Janssen, J. Friedman, X. Deng, Jae Seung Lee, M. Elam, G. Cook, E. Park   +8 more
semanticscholar   +1 more source

Astrocyte in Neurological Disease: Pathogenesis and Therapy

MedComm, Volume 6, Issue 8, August 2025.
This review provides comprehensive overview of astrocytes in neurological disorders. Astrocytes contribute to neurological disorders via A1/A2 polarization, inducing neuroinflammation, synaptic, and BBB dysfunction. Metabolic disturbances in glucose, lipid, and amino acid pathways leading to oxidative stress and mitochondrial damage.
Meihui Huang, Aoyang Long, Lingjia Hao, Zilin Shi, Mengqi Zhang   +4 more
wiley   +1 more source

Diatom triacylglycerol metabolism: from carbon fixation to lipid droplet degradation

Biological Reviews, Volume 100, Issue 4, Page 1423-1443, August 2025.
ABSTRACT Diatoms are a prominent microalgae family that has attracted interest for its production of molecules of biotechnological interest. Their fatty acid profile is rich in health‐beneficial omega‐3 eicosapentaenoic acid (EPA). Furthermore, under nutrient‐deprived conditions, many diatom species, notably Phaeodactylum tricornutum, Thalassiosira ...
Victor Murison, Josiane Hérault, Justine Marchand, Lionel Ulmann   +3 more
wiley   +1 more source

Lipophilic Resazurin in Bioelectrochemical Systems: Role in Regulating Carbon Metabolic Pathways

ChemElectroChem, Volume 12, Issue 14, July 10, 2025.
This study clarifies the mechanism by which lipophilic shuttles regulate carbon metabolism in Shewanella. Lipophilic electron shuttles, such as resazurin, permeate into the periplasm to mediate extracellular electron transfer, thereby altering the redox potential sensed by inner‐membrane quinones and consequently activating the NADH‐dependent metabolic
Siyu Tan, Xiao Zhu, Xinxin Wang, Huangsheng Su, Zongqiang Zhu, Xiaobo Luo, John R. Reinfelder, Yundang Wu, Fangbai Li   +8 more
wiley   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, Volume 599, Issue 13, Page 1821-1851, July 2025.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

An Update: Enzymatic Synthesis for Industrial Applications

Angewandte Chemie International Edition, Volume 64, Issue 27, July 1, 2025.
Biocatalysis has become a sustainable and cost‐competitive alternative to established chemical synthesis, enabling the enzyme‐based production of not only commodity chemicals but (non‐natural) amino acids, (rare) sugars, as well as synthetic nucleotides.
Thomas Bayer, Shuke Wu, Radka Snajdrova, Kai Baldenius, Uwe T. Bornscheuer   +4 more
wiley   +1 more source

PDK4 and nutrient responses explain muscle specific manifestation in mitochondrial disease

Clinical and Translational Medicine, Volume 15, Issue 7, July 2025.
Mitochondrial disease triggers opposite responses in different muscles. Mitochondrial integrated stress response (ISRmt) and aerobic glycolysis characterize large muscles. Eye muscles show no ISRmt but activate PDK4—inhibitor of glucose oxidation—thereby upregulating beta‐oxidation, which is non‐optimal in mitochondrial disease and can explain eye ...
Swagat Pradhan, Takayuki Mito, Nahid A Khan, Sofiia Olander, Aleksandra Zhaivoron, Thomas G McWilliams, Anu Suomalainen   +6 more
wiley   +1 more source