Results 301 to 310 of about 158,743 (322)

Assays of Pyruvate Dehydrogenase Complex and Pyruvate Carboxylase Activity

2011
Pyruvate dehydrogenase complex (PDC) and pyruvate carboxylase (PC) are mitochondrial enzymes that provide the initial steps of the two main alternatives for pyruvate metabolism: oxidative decarboxylation vs. anaplerotic carboxylation, gluconeogenesis, and glycerogenesis.
Douglas, Kerr, George, Grahame, Ghunwa, Nakouzi   +2 more
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Pyruvate Dehydrogenase Complex

1969
Publisher Summary This chapter discusses the multienzyme pyruvate dehydrogenase complexes, with emphasis on their structure, function, and regulation. These complexes have been isolated from Escherichia coli and from animal tissues as functional units with molecular weights in the millions.
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Regulation of the Pyruvate Dehydrogenase Multienzyme Complex

Annual Review of Nutrition, 1993
To maximize catalytic efficiency in metabolic pathways of both prokaryotic and eUkaryotic cells, enzymatic components are occasionally clustered or complexed physically. Organization of multiple catalytic functions into a single enzyme complex can be accomplished in two ways.
R H, Behal, D B, Buxton, J G, Robertson, M S, Olson   +3 more
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The hormonal regulation of pyruvate dehydrogenase complex

Advances in Enzyme Regulation, 1996
The pyruvate dehydrogenase complex has a central role in the regulation of mammalian metabolism as it represents the point-of-no-return in the utilization of carbohydrate. This article summarizes our studies into how signalling systems initiated by hormones binding to cell surface receptors can reach the pyruvate dehydrogenase system which is located ...
Denton, RM, McCormack, JG, Rutter, GA, Burnett, Paul, Edgell, NJ, Moule, SK, Diggle, TA   +6 more
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A mimic of the pyruvate dehydrogenase complex

Bioorganic & Medicinal Chemistry Letters, 2010
Pyruvic acid undergo decarboxylation catalyzed by a hydrophobic thiazolium salt and reacts with a hydrophobic analog of lipoic acid to form a hydrophobic acylthioester that reacts with aniline to form acetanilide in water, but only in the presence of a hydrophobically modified polyaziridine that acts to gather the reactants just as the enzyme complex ...
Huanyu, Zhao, Ronald, Breslow
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Effect of mycoplasma infection on pyruvate dehydrogenase complex activity of normal and pyruvate dehydrogenase complex-deficient fibroblasts

Experimental Cell Research, 1984
The fermentative mycoplasmas A. laidlawii JS, M. hyorhinis DBS-50, M. hyorhinis GDL and M. pneumoniae FH have very high apparent activities of pyruvate dehydrogenase (PDH) (EC 1.2.4.1) and pyruvate dehydrogenase complex (PDHC). Infection of normal and PDHC-deficient fibroblasts with these mycoplasma species resulted in a marked increase of the specific
G J, McGarrity, G, Constantopoulos, J A, Barranger   +2 more
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Fluorescent derivatives of the pyruvate dehydrogenase component of the Escherichia coli pyruvate dehydrogenase complex

Biochemistry, 1977
One sulfhydryl group per polypeptide chain of the pyruvate dehydrogenase component of the pyruvate dehydrogenase multienzyme complex from Escherichia coli was selectively labeled with N-[P-(2-benzoxazoyl)phenyl]-maleimide (NBM), 4-dimethylamino-4-magnitude of-maleimidostilbene (NSM), and N-(4-dimethylamino-3,5-dinitrophenyl)maleimide (DDPM) in 0.05 M ...
N, Papadakis, G G, Hammes
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Regulation of the Human Pyruvate Dehydrogenase Complex

Clinical Science, 1976
1. The pyruvate dehydrogenase complex from human heart has been partially purified and shown to be regulated by a phosphorylation-dephosphorylation cycle similar to that previously found for other mammalian tissues. 2. Incubation of the complex with ATP (2 mmol/l) led to its inactivation associated with the concomitant incorporation into
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Pyruvate Dehydrogenase Complex

RCSB Protein Data Bank, 2012
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[Pyruvate dehydrogenase complex deficiency].

Nihon rinsho. Japanese journal of clinical medicine, 2002
M, Ito, Y, Kuroda
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