Results 31 to 40 of about 22,061 (226)

Blood Biomarkers and Surface‐Enhanced Raman Spectroscopy for Gout: A Comprehensive Review

Advanced Functional Materials, EarlyView.
Schematic illustrating gout disease progression from asymptomatic hyperuricemia to chronic tophaceous disease, highlighting the limitations of conventional imaging and biochemical diagnostics and the potential of engineered SERS platforms for ultrasensitive blood‐based detection of urate‐related biomarkers across disease stages, with the color gradient
Isuri Perera, Chiranjeevi Kanike, Appurva Tiwari, Hongyan Wu, Larry D. Unsworth, Ben Bin Xu, Xuehua Zhang   +6 more
wiley   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Mechanisms of hepatocellular toxicity associated with dronedarone and other mitochondrial toxicants [PDF]

, 2014
Idiosyncratic drug-induced liver injury is a rare toxic event that typically occurs at therapeutic doses, which are generally safe to the majority of patients.
Felser, Andrea Debora
core   +1 more source

Simulations of Pathogenic E1α Variants: Allostery and Impact on Pyruvate Dehydrogenase Complex-E1 Structure and Function

, 2022
Pyruvate dehydrogenase complex (PDC) deficiency is a major cause of primary lactic acidemia resulting in high morbidity and mortality, with limited therapeutic options.
Jirair K. Bedoyan (13014514), Olexandr Isayev (1352004), Hatice Gokcan (13014511)   +2 more
core   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Severe encephalopathy associated to pyruvate dehydrogenase mutations and unbalanced coenzyme Q10 content [PDF]

, 2016
Coenzyme Q10 (CoQ10) deficiency is associated to a variety of clinical phenotypes including neuromuscular and nephrotic disorders. We report two unrelated boys presenting encephalopathy, ataxia, and lactic acidosis, who died with necrotic lesions in ...
Paz Briones, O''Callaghan, M. M., Cortés, A., Rodríguez-Hernandez, M. A., Asencio, Claudio, Gavil''n, A., Yubero, D., Montero, R., Artuch, Rafael, Montoya, J., María Alcázar-Fabra, Eduardo Ruiz-Pesini, Leonardo Salviati, Gavilán, Angela, Mercedes Pineda, Emperador, Sonia, Briones, P., Yubero, Dèlia, Alcázar-Fabra, María, Artuch, R., Asencio, C., Raquel Montero, María A Rodríguez-Hernandez, Sonia Emperador, Ruiz-Pesini, E., Rodríguez-Hernandez, María A, Ana Cortés, Pineda, M., Dèlia Yubero, Claudio Asencio, O'Callaghan, María M, Montero, Raquel, Salviati, Leonardo, Rafael Artuch, Briones, Paz, Montoya, Julio, Plácido Navas, Cortés, Ana, Pineda, Mercedes, Emperador, S., Alcázar-Fabra, M., Ruiz-Pesini, Eduardo, Salviati, L., María M O'Callaghan, Navas, Plácido, Julio Montoya, Angela Gavilán, Navas, P.   +47 more
core   +2 more sources

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

A Brain‐Wide Atlas of Astrocytic Oxytocin Receptors Reveals a Glial Basis for Nucleus Accumbens Modulation of Affiliative Behavior

Advanced Science, EarlyView.
The cellular actors of oxytocin signaling are under intense scrutiny. A brain‐wide anatomical and functional analysis in mice and rats reveals widespread expression of oxytocin receptors in astrocytes. These receptors are functionally active and, in the nucleus accumbens, selectively regulate male social affiliation.
Clémence Denis, Stefan Stojilkovic, Kai‐Yi Wang, Cristina Márquez, Annabel C. Kleinwächter, Angel Baudon, Yuval Podpecan, Aurélia Ces, Mélanie Kremer, Isabelle Arnoux, Nathalie Rouach, Jemima Helen, Sophie Trender, Andreas Wallkum, Selina Wunsch, Franziska Schommer, Moritz C. Wimmer, Tim Schubert, Felix Franke, Jabir Aliyu Muhammad, Eva M. Eisemann, Ingrid Camila Possa‐Paranhos, Cassandra Baumann, Pierre‐Alexis Derrien, Quirin Krabichler, Cosmo Garcia, Henning Fröhlich, Matthew K. Kirchner, Valery Grinevich, Pascal Darbon, Javier E. Stern, Ferdinand Althammer, Alexandre Charlet   +32 more
wiley   +1 more source

Profiling trait anxiety: transcriptome analysis reveals cathepsin B (Ctsb) as a novel candidate gene for emotionality in mice. [PDF]

, 2011
Behavioral endophenotypes are determined by a multitude of counteracting but precisely balanced molecular and physiological mechanisms. In this study, we aim to identify potential novel molecular targets that contribute to the multigenic trait "anxiety".
Holsboer, Florian, Pütz Benno, Graf Cornelia, Peters, C., Bunck, Mirjam, Rieder, G., Steiner, Andrea, Baur Laura A., Mirjam Bunck, Markus Panhuysen, Rieder, Gabriele, Benno Pütz, Gabriele Rieder, Pütz, Benno, Claudia Kühne, Czibere Ludwig, Deussing, Jan, Laura A Baur, Weber Peter, Bunck, M., Peters, Christoph, Holsboer Florian, Graf, C., Czibere, L., Gemmeke, K., Cornelia Graf, Nafees Ahmad, Laura A. Baur, Widner, R., Graf, Cornelia, Hambsch Boris, Wittmann, A., Hambsch, B., Christoph Peters, Steiner Andrea, Peters Christoph, Weber, Peter, Ahmad, Nafees H.M., Wittmann, Anke, Kühne, C., Widner Regina, Panhuysen Markus, Landgraf Rainer, Reinheckel Thomas, Ahmad, N., Katja Gemmeke, Bunck Mirjam, Ludwig Czibere, Ahmad Nafees, Boris Hambsch, Wittmann Anke, Peter Weber, Deussing, Jan M., Rieder Gabriele, Holsboer, F., Panhuysen, Markus, Andrea Steiner, Reinheckel, Thomas, Kühne Claudia, Hambsch, Boris, Gemmeke Katja, Baur, L., Kühne, Claudia, Weber, P., Gemmeke, Katja, Thomas Reinheckel, Czibere, Ludwig, Jan M Deussing, Widner, Regina, Deussing, J., Ahmad, Nafees, Rainer Landgraf, Anke Wittmann, Pütz, B., Landgraf, R., Reinheckel, T., Florian Holsboer, Baur, Laura A., Landgraf, Rainer, Deussing Jan M., Panhuysen, M., Jan M. Deussing, Steiner, A., Regina Widner   +83 more
core   +1 more source