Results 51 to 60 of about 80,914 (291)

The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility [PDF]

Nutrition & Metabolism, 2014
Metabolic flexibility is the capacity of a system to adjust fuel (primarily glucose and fatty acids) oxidation based on nutrient availability. The ability to alter substrate oxidation in response to nutritional state depends on the genetically influenced balance between oxidation and storage capacities.
Zhang, Shuai, Hulver, Matthew W., McMillan, Ryan P., Cline, Mark A., Gilbert, Elizabeth R.   +4 more
openaire   +3 more sources

The phosphoenolpyruvate (PEP)-pyruvate-oxaloacetate node in C. glutamicum.

, 2016
Abbreviations: AK, acetate kinase; PTA, phosphotransacetylase; CA, carbonic anhydrase; CS, citrate synthase; ACN, aconitase; ICD, isocitrate dehydrogenase; OGDHC, oxoglutarate dehydrogenase complex; ICL, isocitrate lyase; MS, malate synthase; MalE, malic
Bernhard J. Eikmanns (2633149), Adnan Shah (2633152)   +1 more
core   +1 more source

Design, Synthesis, and Evaluation of Novel Pyruvate Dehydrogenase Kinase Inhibitors [PDF]

, 2023
peer reviewedThe present work describes the synthesis and the biological evaluation of novel compounds acting as pyruvate dehydrogenase kinase (PDK) inhibitors.
Arslan, Deniz, Zorzi, Danièle, Schoumacher, Matthieu, De Tullio, Pascal, Noël, Agnès, Quatresooz, Pascale, Lambert, Vincent, Pirotte, Bernard, Dilly, Sébastien, Elmoualij, Benaïssa   +9 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

Theoretical Analysis of the Built-in Metabolic Pathway Effect on the Metabolism of Erythrocyte-Bioreactors That Neutralize Ammonium

Metabolites, 2021
The limitations of the efficiency of ammonium-neutralizing erythrocyte-bioreactors based on glutamate dehydrogenase and alanine aminotransferase reactions were analyzed using a mathematical model.
Evgeniy Protasov, Larisa Koleva, Elizaveta Bovt, Fazoil I. Ataullakhanov, Elena Sinauridze   +4 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Pathogenic mechanisms underlying X-linked Charcot-Marie-Tooth neuropathy (CMTX6) in patients with a pyruvate dehydrogenase kinase 3 mutation

Neurobiology of Disease, 2016
Charcot-Marie-Tooth disease (CMT) is the most common inherited peripheral neuropathy. An X-linked form of CMT (CMTX6) is caused by a missense mutation (R158H) in the pyruvate dehydrogenase kinase isoenzyme 3 (PDK3) gene.
Gonzalo Perez-Siles, Carolyn Ly, Adrienne Grant, Alexander P. Drew, Eppie M. Yiu, Monique M. Ryan, David T. Chuang, Shih-Chia Tso, Garth A. Nicholson, Marina L. Kennerson   +9 more
doaj   +1 more source

Inhibitory pyruvate dehydrogenase phosphorylation and pyruvate dehydrogenase kinases and phosphatases transcript expression.

, 2014
Inhibitory phosphorylation levels at three pyruvate dehydrogenase serine residues and transcript expression of pyruvate dehydrogenase kinases and phosphatases for NHA IDHmut cells expressed as a percentage of their IDHwt counterparts.
Pia Eriksson (405859), Myriam M. Chaumeil (632682), Sabrina M. Ronen (342173), Aaron E. Robinson (140561), Larry M. Cai (632681), Jose L. Izquierdo-Garcia (405860), Joanna J. Phillips (140583), Russell O. Pieper (221241)   +7 more
core   +1 more source