Results 101 to 110 of about 64,563 (283)

Bioinformatics‐based discovery of the involvement of PSAT1 in mediating the anti‐lung adenocarcinoma activity of triptolide

Animal Models and Experimental Medicine, EarlyView.
Transcriptome sequencing was performed on tumor tissues from triptolide‐treated tumor‐bearing mice. The sequencing results were integrated with data from public databases for comprehensive analysis, and potential regulatory targets of triptolide were identified.
Zhiwen Cao, Lulu Zhang, Wenqiang Zhang, Rong Wan, Xiaogang Peng, Jinyan Xie, Ruru Bai, Jiejing Jin, Changqi Shi, Lan Yan, Xiangyu Guo, Yang Shen, Cheng Lu   +12 more
wiley   +1 more source

Targeting pyruvate metabolism generates distinct CD8+ T cell responses to gammaherpesvirus and B lymphoma

JCI Insight
T cells rely on different metabolic pathways to differentiate into effector or memory cells, and metabolic intervention is a promising strategy to optimize T cell function for immunotherapy.
Taewook Kang, Young-Kwang Usherwood, Julie A. Reisz, Sukrut C. Kamerkar, Rachel Culp-Hill, Owen M. Wilkins, Andreia F. Verissimo, Fred W. Kolling IV, Anton M. Hung, Shawn C. Musial, Pamela C. Rosato, Angelo D’Alessandro, Henry N. Higgs, Edward J. Usherwood   +13 more
doaj   +1 more source

The investigation of the influence which is done as a result of macleaya cordata and biologically active additives on the carbohydrate metabolism in pigs

Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького: Серія Ветеринарні науки, 2019
Pork production plays a significant role in meat balance of Ukraine. High productivity of pigs is accompanied with increased intensity of metabolic processes and intense functional activity of all organs and systems, which requires additional support. To
I. O. Zhukova, A. A. Molchanov, I. O. Kostiuk, O. M. Bobrytska, N. I. Lonhus, I. A. Ionov   +5 more
doaj   +1 more source

A cell-penetrating PHLPP peptide improves cardiac arrest survival in murine and swine models

The Journal of Clinical Investigation, 2023
Out-of-hospital cardiac arrest is a leading cause of death in the US, with a mortality rate over 90%. Preclinical studies demonstrate that cooling during cardiopulmonary resuscitation (CPR) is highly beneficial, but can be challenging to implement ...
Jing Li, Xiangdong Zhu, Matt T. Oberdier, Chunpei Lee, Shaoxia Lin, Sarah J. Fink, Cody N. Justice, Kevin Qin, Andrew W. Begeman, Frederick C. Damen, Hajwa Kim, Jiwang Chen, Kejia Cai, Henry R. Halperin, Terry L. Vanden Hoek   +14 more
doaj   +1 more source

SUN-465 A Rare Germline Loss-of-Function Variant in the Pyruvate Dehydrogenase Phosphatase Catalytic Subunit 2 Gene in a Patient with Abdominal Paraganglioma [PDF]

J Endocr Soc
Felipe Freitas-Castro, Gustavo Freitas Cardoso Fagundes, Lucas Santos de Santana, Ana Caroline F Afonso, Felipe L Ledesma, Iberê Cauduro Soares, Berenice B. Mendonça, Ana Cláudia Latronico, Madson Q. Almeida   +8 more
europepmc   +3 more sources

Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis. [PDF]

, 2013
Miner1 is a redox-active 2Fe2S cluster protein. Mutations in Miner1 result in Wolfram Syndrome, a metabolic disease associated with diabetes, blindness, deafness, and a shortened lifespan.
Andreyev, Alexander Y, Chen, Yi-Fan, Divakaruni, Ajit S, Dixon, Jack E, Karisch, Robert, Murphy, Anne N, Neel, Benjamin G, Perkins, Guy, Simon, Melvin I, Tsai, Ting-Fen, van der Geer, Peter, Wall, Estelle A, Wiley, Sandra E   +12 more
core   +1 more source

Heat Stress and Gut Microbiome Dynamics in Poultry: Interplay, Consequences, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts gut microbial balance in poultry, impairing nutrient absorption and immunity. This review outlines the interplay between thermal stress and microbiome dynamics and discusses integrative mitigation strategies, probiotics, phytogenics, cooling systems, and genetic adaptation to enhance poultry resilience.
O. E. Oke, A. I. Oni, O. A. Akosile, K. M. Oliyide, C. A. Ishola, M. O. Logunleko, O. A. Jimoh, C. P. Njoku, L. O. Fasasi, V. A. Uyanga   +9 more
wiley   +1 more source

RECENT ADVANCES IN TARGETING PROTEINS AND ENZYMES ASSOCIATED WITH DIABETIC PATHOPHYSIOLOGY

International Journal of Pharmacy & Integrated Health Sciences
Background: Diabetes mellitus is a multifactorial metabolic disorder involving several pathways, i.e., enzymes and proteins, and is a major causing morbidity and mortality worldwide.
Mubarak Muhammad Dahiru
doaj   +1 more source

Identification of histone deacetylase inhibitor targeting type I interferon and B‐cell abnormalities in systemic lupus erythematosus

Arthritis &Rheumatology, Accepted Article.
Objective Systemic lupus erythematosus (SLE) is characterized by increased type I interferon (IFN‐I) and autoantibody production. This study aimed to identify drugs that can inhibit both IFN‐I and autoantibody production. Methods We identified an inhibitor of IFN‐I production from a chemical library.
Takehiro Hirayama, Hachiro Konaka, Yasuhiro Kato, Takayuki Shibahara, Chisato Nishizawa, Kohei Tsujimoto, JeongHoon Park, Eri Itotagawa, Tatsunori Jo, Masayuki Nishide, Sumiyuki Nishida, Yoshihito Shima, Masashi Narazaki, Wataru Aoki, Ken J Ishii, Hyota Takamatsu, Atsushi Kumanogoh   +16 more
wiley   +1 more source

Industrial strategies to minimize glycerol formation in ethanol fermentation by conventional Saccharomyces cerevisiae

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract Industrial ethanol production faces the challenge of balancing metabolic efficiency with the minimization of byproducts such as glycerol, whose formation is intensified by osmotic, thermal, oxidative, and nutritional stresses. In the literature, two main approaches stand out for modulating its synthesis: the use of genetically modified strains
Lorena M. F. Leite, Silvio R. Andrietta, Telma T. Franco   +2 more
wiley   +1 more source